CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis

scientific article

CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-13-1617
P932PMC publication ID6005686
P698PubMed publication ID24366883

P2093author name stringMichael A James
Ming You
Haris G Vikis
Amy L Rymaszewski
Everett Tate
P2860cites workFunctional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locusQ21134596
NIH Image to ImageJ: 25 years of image analysisQ23319322
Network organization of the human autophagy systemQ24324004
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33Q24597370
Common 5p15.33 and 6p21.33 variants influence lung cancer riskQ24646182
Lung cancer susceptibility locus at 5p15.33Q24649980
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinomaQ24657797
A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosisQ28143357
TERT-CLPTM1L polymorphism rs401681 contributes to cancers risk: evidence from a meta-analysis based on 29 publicationsQ28391602
CLPTM1L is overexpressed in lung cancer and associated with apoptosisQ28484554
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility lociQ28943367
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controlsQ29417049
Sequence variants at the TERT-CLPTM1L locus associate with many cancer typesQ29614935
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinaseQ30490786
Cumulative effect of multiple loci on genetic susceptibility to familial lung cancerQ33758154
The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).Q33962748
No association between TERT-CLPTM1L single nucleotide polymorphism rs401681 and mean telomere length or cancer riskQ33982873
Regulation of Bcl-xL: a little bit of this and a little bit of STAT.Q34086142
The association of telomere length and genetic variation in telomere biology genesQ34101736
Amplified genes may be overexpressed, unchanged, or downregulated in cervical cancer cell lines.Q34193299
Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancerQ34760231
The PTEN, Mdm2, p53 tumor suppressor-oncoprotein networkQ34825957
Calreticulin promotes cell motility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal squamous cell carcinomaQ34997748
Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk.Q35230314
Activated Ras prevents downregulation of Bcl-X(L) triggered by detachment from the extracellular matrix. A mechanism of Ras-induced resistance to anoikis in intestinal epithelial cellsQ36328354
Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.Q36625664
Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4Q37008951
Mapping cis- and trans-regulatory effects across multiple tissues in twinsQ37200482
Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinomaQ37428076
The PKB/AKT pathway in cancerQ37705534
Prevalence of telomerase activity in human cancerQ37881333
Association of the 15q25 and 5p15 lung cancer susceptibility regions with gene expression in lung tumor tissueQ38325774
Atypical protein kinase Cι (PKCι) promotes metastasis of esophageal squamous cell carcinoma by enhancing resistance to Anoikis via PKCι-SKP2-AKT pathwayQ39594432
Bcl-XL small interfering RNA sensitizes cisplatin-resistant human lung adenocarcinoma cellsQ40134737
Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenanceQ40351772
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapyQ40765673
Inactivation of both Rb and p53 pathways in mouse lung epithelial cell linesQ40813970
Homozygous codeletion and differential decreased expression of p15INK4b, p16INK4a-alpha and p16INK4a-beta in mouse lung tumor cells.Q41151873
K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression.Q42833403
Fine-mapping of a region of chromosome 5p15.33 (TERT-CLPTM1L) suggests a novel locus in TERT and a CLPTM1L haplotype are associated with glioma susceptibility in a Chinese populationQ47236669
The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lungQ47735621
Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma.Q54526774
Common genetic variants in TERT contribute to risk of cervical cancer in a Chinese population.Q54537700
Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial colon cellsQ83828670
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1116-1127
P577publication date2013-12-23
P1433published inCancer ResearchQ326097
P1476titleCRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis
P478volume74

Reverse relations

cites work (P2860)
Q41231769A GWAS in uveal melanoma identifies risk polymorphisms in the CLPTM1L locus
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Q47135982CLPTM1L gene rs402710 (C > T) and rs401681 (C > T) polymorphisms associate with decreased cancer risk: a meta-analysis
Q28385765Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk
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