Activation of p38 Mitogen-Activated Protein Kinase and c-Jun-NH2-Terminal Kinase by BMP-2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation

scientific article published on November 1, 2003

Activation of p38 Mitogen-Activated Protein Kinase and c-Jun-NH2-Terminal Kinase by BMP-2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation is …
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scholarly articleQ13442814

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P356DOI10.1359/JBMR.2003.18.11.2060
P953full work available at URLhttps://academic.oup.com/jbmr/article-pdf/18/11/2060/56470681/5650181118.pdf
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1359%2Fjbmr.2003.18.11.2060
P698PubMed publication ID14606520
P5875ResearchGate publication ID9017646

P50authorChafik GhayorQ42834864
Jérome GuicheuxQ42834877
Gaby PalmerQ62668405
P2093author name stringA. Suzuki
J. Lemonnier
J. Caverzasio
P2860cites workMurine osteoblastlike cells and the osteogenic cell MC3T3-E1 release a macrophage colony-stimulating activity in cultureQ70362573
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Tensile stress induces bone morphogenetic protein 4 in preosteoblastic and fibroblastic cells, which later differentiate into osteoblasts leading to osteogenesis in the mouse calvariae in organ cultureQ73374689
Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cellsQ73853205
Effects of bone morphogenetic protein-2 on human neonatal calvaria cell differentiationQ74455662
Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein-4-stimulated osteocalcin synthesis in osteoblastsQ77551513
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinaseQ77906539
Regulation of alkaline phosphatase activity by p38 MAP kinase in response to activation of Gi protein-coupled receptors by epinephrine in osteoblast-like cellsQ77932849
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Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcriptionQ24311810
Smads bind directly to the Jun family of AP-1 transcription factorsQ24685193
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone developmentQ28119185
TGF-beta signalling from cell membrane to nucleus through SMAD proteinsQ28131770
ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signalingQ28139205
Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to developmentQ28268881
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinaseQ28364720
Structure and expression of rat osteosarcoma (ROS 17/2.8) alkaline phosphatase: product of a single copy geneQ28583797
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinaseQ28628494
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblastsQ29547605
AP-1 in cell proliferation and survivalQ29615217
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Bone morphogenetic proteins: an update on basic biology and clinical relevanceQ33604511
MAP kinase pathwaysQ33650641
The stress-activated protein kinase pathwaysQ33732869
The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cellsQ34434997
Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblastsQ37388231
Regulation of differentiation pathway of skeletal mesenchymal cells in cell lines by transforming growth factor-beta superfamilyQ40406239
Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrixQ40699220
Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription.Q40722201
Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12.Q41069920
Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblastsQ41090627
Complementary DNA for human T-cell cyclophilin.Q41338019
In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvariaQ41387920
Bone morphogenetic proteins (BMP-2 and BMP-3) promote growth and expression of the differentiated phenotype of rabbit chondrocytes and osteoblastic MC3T3-E1 cells in vitroQ41655612
Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cellsQ42818438
Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiationQ42819769
Mechanism of the mitogenic effect of fluoride on osteoblast-like cells: evidences for a G protein-dependent tyrosine phosphorylation process.Q42833404
Inhibition of PI3K/p70 S6K and p38 MAPK cascades increases osteoblastic differentiation induced by BMP-2.Q43832936
Stress-activated protein kinase/c-Jun N-terminal kinase (JNK) plays a part in endothelin-1-induced vascular endothelial growth factor synthesis in osteoblastsQ44192460
Bone morphogenetic protein-2 stimulates alkaline phosphatase activity and collagen synthesis in cultured osteoblastic cells, MC3T3-E1Q68186574
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
Orthopedics and sports medicineQ72419165
P304page(s)2060-2068
P577publication date2003-11-01
P1433published inJournal of Bone and Mineral ResearchQ15750941
P1476titleActivation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation
Activation of p38 Mitogen-Activated Protein Kinase and c-Jun-NH2-Terminal Kinase by BMP-2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation
P478volume18

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