A novel approach for using dielectric spectroscopy to predict viable cell volume (VCV) in early process development

scientific article published on March 2014

A novel approach for using dielectric spectroscopy to predict viable cell volume (VCV) in early process development is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/BTPR.1845
P932PMC publication ID4162991
P698PubMed publication ID24851255
P5875ResearchGate publication ID259536122

P2093author name stringJeffrey F Breit
Brandon J Downey
Lisa J Graham
Nathaniel K Glutting
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On-line monitoring of infected Sf-9 insect cell cultures by scanning permittivity measurements and comparison with off-line biovolume measurementsQ36183830
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Membrane dielectric changes indicate induced apoptosis in HL-60 cells more sensitively than surface phosphatidylserine expression or DNA fragmentationQ37303786
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Process control in cell culture technology using dielectric spectroscopyQ37855046
Rapid assessment of early biophysical changes in K562 cells during apoptosis determined using dielectrophoresis.Q39127648
On metabolic shift to lactate consumption in fed-batch culture of mammalian cellsQ39412470
Multifrequency permittivity measurements enable on-line monitoring of changes in intracellular conductivity due to nutrient limitations during batch cultivations of CHO cellsQ39777344
Cell-based screening for membranal and cytoplasmatic markers using dielectric spectroscopy.Q39988826
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On-line Measurements and Control of Viable Cell Density in Cell Culture Manufacturing Processes using Radio-frequency ImpedanceQ41782730
Dielectric spectroscopy of plant protoplastsQ42184791
Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopyQ43246624
On‐line biomass monitoring of CHO perfusion culture with scanning dielectric spectroscopyQ44629150
Distinguishing between apoptosis and necrosis using a capacitance sensor.Q46114092
Cell size distribution as a parameter for the predetermination of exponential growth during repeated batch cultivation of CHO cellsQ47225010
Quantitative modeling of viable cell density, cell size, intracellular conductivity, and membrane capacitance in batch and fed-batch CHO processes using dielectric spectroscopy.Q47418193
Purification of rat hepatic stellate cells by side scatter-activated cell sorting.Q50525615
Comparison of trypan blue dye exclusion and fluorometric assays for mammalian cell viability determinations.Q50778803
Differences in the biophysical properties of membrane and cytoplasm of apoptotic cells revealed using dielectrophoresis.Q51246948
Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture.Q51754828
Effect of shape on the dielectric properties of biological cell suspensions.Q51917588
Process analytical technology (PAT) for biopharmaceutical products: Part II. Concepts and applications.Q53497670
PLS-regression: a basic tool of chemometricsQ56454404
Dielectric permittivity of microbial suspensions at radio frequencies: a novel method for the real-time estimation of microbial biomassQ56975322
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A method for determining the dielectric constant and the conductivity of membrane-bounded particles of biological relevanceQ57140594
P433issue2
P304page(s)479-487
P577publication date2014-03-01
P1433published inBiotechnology ProgressQ15753227
P1476titleA novel approach for using dielectric spectroscopy to predict viable cell volume (VCV) in early process development
P478volume30

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cites work (P2860)
Q47576109A robust feeding strategy to maintain set-point glucose in mammalian fed-batch cultures when input parameters have a large error
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Q38641846Trends in Process Analytical Technology: Present State in Bioprocessing

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