Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts

scientific article published on 25 February 2010

Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1600-0625.2010.01065.X
P932PMC publication ID3826663
P698PubMed publication ID20201953

P50authorMaria TrojanowskaQ35703497
Andreea M BujorQ42525588
P2093author name stringErin Morris
Faye N Hant
Sashidar Nakerakanti
P2860cites workEnhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathwaysQ74230888
Randomised double-blind placebo controlled trial of topical autologous platelet lysate in venous ulcer healingQ74312269
Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by plateletsQ81144479
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factorsQ24806147
Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis modelQ28142724
MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Mdm2 is activated in response to inhibited Akt signalingQ28580290
Regulation of wound healing by growth factors and cytokinesQ29615242
How matrix metalloproteinases regulate cell behaviorQ29620360
The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblastsQ33928429
Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patientsQ34140774
Bisperoxovanadium compounds are potent PTEN inhibitors.Q34321332
Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repairQ34437758
Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: a role for connective tissue growth factor in contractile scarringQ35843492
Akt: versatile mediator of cell survival and beyondQ36296940
Na/H exchange regulatory factor 1, a novel AKT-associating protein, regulates extracellular signal-regulated kinase signaling through a B-Raf-mediated pathway.Q36536571
Connective tissue growth factor: structure-function relationships of a mosaic, multifunctional proteinQ37144234
Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in miceQ38288770
Inhibition of 12-LOX and COX-2 reduces the proliferation of human epidermoid carcinoma cells (A431) by modulating the ERK and PI3K-Akt signalling pathwaysQ39832622
Heat-induced MMP-1 expression is mediated by TRPV1 through PKCalpha signaling in HaCaT cellsQ39978624
Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytesQ40326104
Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signalsQ40583820
Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases.Q40731011
CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK).Q40765291
Cytokine regulation of metalloproteinase gene expressionQ40810974
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.Q40915594
PTEN: a promising pharmacological target to enhance epithelial wound healingQ41847531
Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblastsQ42525511
TGF-beta and CTGF have overlapping and distinct fibrogenic effects on human renal cellsQ44129279
Interleukin-1alpha and collagenase activity are elevated in chronic woundsQ45113595
Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosisQ46078186
Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.Q46797117
Gene expression profiles from hypertrophic scar fibroblasts before and after IL-6 stimulationQ47739053
Differential Expression of Matrix Metalloproteinases During Impaired Wound Healing of the Diabetes MouseQ58211774
Temporal activity of plasminogen activators and matrix metalloproteinases during cutaneous wound repairQ60152145
Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcersQ71049641
Collagenase production is lower in post-burn hypertrophic scar fibroblasts than in normal fibroblasts and is reduced by insulin-like growth factor-1Q71120740
P433issue4
P304page(s)347-354
P577publication date2010-02-25
P1433published inExperimental DermatologyQ15749509
P1476titleAkt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts
P478volume19

Reverse relations

cites work (P2860)
Q44675085Bioactive reagents used in mesotherapy for skin rejuvenation in vivo induce diverse physiological processes in human skin fibroblasts in vitro- a pilot study
Q33961583CCN2 is required for the TGF-β induced activation of Smad1-Erk1/2 signaling network
Q42142681Caveolin-1 is a negative regulator of MMP-1 gene expression in human dermal fibroblasts via inhibition of Erk1/2/Ets1 signaling pathway.
Q47774829Chronic exposure of interleukin-13 suppress the induction of matrix metalloproteinase-1 by tumour necrosis factor α in normal and scleroderma dermal fibroblasts through protein kinase B/Akt.
Q39987550Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1.
Q42501087Elevated expression of cav-1 in a subset of SSc fibroblasts contributes to constitutive Alk1/Smad1 activation.
Q39119229PDK1 controls upstream PI3K expression and PIP3 generation.
Q45207121Platelet lysate modulates MMP-2 and MMP-9 expression, matrix deposition and cell-to-matrix adhesion in keratinocytes and fibroblasts.
Q36054245The c-Abl tyrosine kinase controls protein kinase Cδ-induced Fli-1 phosphorylation in human dermal fibroblasts
Q39552590Thymus and activation-regulated chemokine (TARC)/CC chemokine ligand (CCL) 17 accelerates wound healing by enhancing fibroblast migration

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