Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1.

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Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/IJMM.2012.1150
P932PMC publication ID4035782
P698PubMed publication ID23041765
P5875ResearchGate publication ID232220502

P50authorMaria TrojanowskaQ35703497
Andreea M BujorQ42525588
Percival D Sampaio-BarrosQ56867885
P2093author name stringRomy B Christmann
Paul Haines
Robert Lafyatis
Andreea M Bujor
Cristina Padilla
Monica Junie
P2860cites workEffect of topical fluoroquinolones on the expression of matrix metalloproteinases in the corneaQ24805406
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Fine mapping of Leishmania major susceptibility Locus lmr2 and evidence of a role for Fli1 in disease and wound healingQ33877106
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Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skinQ35791840
The c-Abl tyrosine kinase controls protein kinase Cδ-induced Fli-1 phosphorylation in human dermal fibroblastsQ36054245
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CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signalingQ42498294
Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblastsQ42525511
Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblastsQ42908910
Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathyQ44213857
Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene programQ45184208
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Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylateQ46453980
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Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.Q46797117
Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblastsQ46815041
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Scleroderma fibroblasts demonstrate enhanced activation of Akt (protein kinase B) in situ.Q53872781
Ciprofloxacin up-regulates tendon cells to express matrix metalloproteinase-2 with degradation of type I collagen.Q54141807
The Effect of Ciprofloxacin on Tendon, Paratenon, and Capsular Fibroblast MetabolismQ56658493
Fli-1 Inhibits Collagen Type I Production in Dermal Fibroblasts via an Sp1-dependent PathwayQ60537820
Effects of hepatic stimulator substance, herbal medicine, selenium/vitamin E, and ciprofloxacin on cirrhosis in the ratQ71035615
Decreased collagenase expression in cultured systemic sclerosis fibroblastsQ72166912
Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblastsQ73628355
Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblastsQ79795007
Cartilage oligomeric matrix protein expression in systemic sclerosis reveals heterogeneity of dermal fibroblast responses to transforming growth factor betaQ81071159
Epidermal growth factor affects the synthesis and degradation of type I collagen in cultured human dermal fibroblastsQ82265444
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1473-1480
P577publication date2012-10-05
P1433published inInternational Journal of Molecular MedicineQ6051492
P1476titleCiprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1.
P478volume30