Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts

scientific article published on 01 July 2003

Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/ART.11157
P698PubMed publication ID12847691

P2093author name stringShu-Jen Chen
John Varga
Yasuji Mori
P2860cites workDeficient Smad7 expression: a putative molecular defect in sclerodermaQ34021184
P433issue7
P304page(s)1964-1978
P577publication date2003-07-01
P1433published inArthritis and RheumatismQ23929027
P1476titleExpression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts
P478volume48

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cites work (P2860)
Q90467962A novel miRNA-4484 is up-regulated on microarray and associated with increased MMP-21 expression in serum of systemic sclerosis patients
Q33637862A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses
Q54962214Abrogation of transforming growth factor-β-induced tissue fibrosis in TBRIcaCol1a2Cre transgenic mice by the second generation tyrosine kinase inhibitor SKI-606 (Bosutinib).
Q35863725Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
Q42525511Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts
Q35689019Antifibrotic therapy in scleroderma: extracellular or intracellular targeting of activated fibroblasts?
Q34358613Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
Q37903252Autoimmune mechanisms of scleroderma and a role of oxidative stress
Q37621644Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression.
Q39987550Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1.
Q35070899Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors
Q35170133Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gamma
Q38327280Constitutive thrombospondin-1 overexpression contributes to autocrine transforming growth factor-beta signaling in cultured scleroderma fibroblasts
Q38543692Cytokines in the immunopathology of systemic sclerosis
Q37866690Deconstructing fibrosis research: do pro-fibrotic signals point the way for chronic dermal wound regeneration?
Q42600316Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis
Q41037995Differentiation, apoptosis, and GM-CSF receptor expression of human gingival fibroblasts on a titanium surface treated by a dual acid-etched procedure
Q34555185Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels
Q84164263Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis
Q34447925Fibrillin assemblies: extracellular determinants of tissue formation and fibrosis
Q37791685Fibrosis and immune dysregulation in systemic sclerosis
Q34687049Ha-Ras stabilization mediates pro-fibrotic signals in dermal fibroblasts.
Q42354635Helen Ollendorff Curth: A dermatologist's lasting legacy.
Q42354702Helen Ollendorff-Curth: A dermatologist's lasting legacy
Q35745090Hematopoietic stem cell-derived cancer-associated fibroblasts are novel contributors to the pro-tumorigenic microenvironment
Q34257607Histone deacetylase: a potential therapeutic target for fibrotic disorders
Q64096057Identification of regulators of the myofibroblast phenotype of primary dermal fibroblasts from early diffuse systemic sclerosis patients
Q37386864Imatinib mesylate causes genome-wide transcriptional changes in systemic sclerosis fibroblasts in vitro.
Q37509808Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity
Q89766137Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis
Q28288338Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis
Q35094477Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease
Q36577428Mechanisms and consequences of fibrosis in systemic sclerosis
Q26781257MicroRNAs Regulating Signaling Pathways: Potential Biomarkers in Systemic Sclerosis
Q36354729Molecular aspects of regulation of collagen gene expression in fibrosis.
Q33745028PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis
Q37326935Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator
Q28238030Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes
Q26863751Recent developments in myofibroblast biology: paradigms for connective tissue remodeling
Q37688362SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis
Q36506934Scar wars: is TGFbeta the phantom menace in scleroderma?
Q36067741Scleroderma, fibroblasts, signaling, and excessive extracellular matrix
Q36891532Smad-independent transforming growth factor-beta regulation of early growth response-1 and sustained expression in fibrosis: implications for scleroderma
Q35649427Systemic sclerosis: a prototypic multisystem fibrotic disorder
Q58659630T cell repertoire in patients with stable scleroderma
Q35102837Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma
Q35899944The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling
Q37852901The lens as a model for fibrotic disease
Q52657100The non-neuronal cyclin-dependent kinase 5 is a fibrotic mediator potentially implicated in systemic sclerosis and a novel therapeutic target.
Q35689005The pathogenesis of fibrosis and renal disease in scleroderma: recent insights from glomerulosclerosis
Q58783029The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis
Q34452923Therapeutic potential of trichostatin A to control inflammatory and fibrogenic disorders of the ocular surface
Q41347489Towards an anti-fibrotic therapy for scleroderma: targeting myofibroblast differentiation and recruitment
Q34232534Transforming growth factor-beta and fibrosis
Q25255541Tweaking microtubules to treat scleroderma
Q37638268Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities
Q36717858Valproic acid suppresses collagen by selective regulation of Smads in conjunctival fibrosis
Q64046177[Systemic sclerosis: pathophysiology of a multifaceted disease]

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