Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin

scientific article published on 22 August 2009

Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MCE.2009.08.011
P932PMC publication ID2815206
P698PubMed publication ID19703515
P5875ResearchGate publication ID223440157

P2093author name stringYi Zhang
Edwards A Park
Marshall B Elam
Ramy R Attia
George A Cook
Farhana Chowdhury
Sara Connaughton
Shulan Song
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PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolismQ34230877
Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growthQ34236816
Regulation of the activity of the pyruvate dehydrogenase complexQ34747160
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CCAAT/enhancer-binding protein beta is an accessory factor for the glucocorticoid response from the cAMP response element in the rat phosphoenolpyruvate carboxykinase gene promoterQ38327938
Hepatocyte nuclear factor-4 alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1 alpha (PGC-1 alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cellsQ38361326
The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymesQ39451469
Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2.Q40084257
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.Q40122836
Insulin represses phosphoenolpyruvate carboxykinase gene transcription by causing the rapid disruption of an active transcription complex: a potential epigenetic effectQ40210118
Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expressionQ40213332
The metabolic effects of dichloroacetateQ40314463
Characterization of the transactivation domain in the peroxisome-proliferator-activated receptor gamma co-activator (PGC-1).Q41892879
Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivationQ42009070
Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidismQ42048511
The three insulin response sequences in the glucose-6-phosphatase catalytic subunit gene promoter are functionally distinctQ42436400
Peroxisome proliferator-activated receptor gamma coactivator-1alpha, as a transcription amplifier, is not essential for basal and hormone-induced phosphoenolpyruvate carboxykinase gene expressionQ42459200
The STAT5A-mediated induction of pyruvate dehydrogenase kinase 4 expression by prolactin or growth hormone in adipocytesQ42830162
Control of pyruvate dehydrogenase kinase gene expressionQ43625199
Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha.Q43735852
Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulinQ43867510
Insulin inhibits hepatocellular glucose production by utilizing liver-enriched transcriptional inhibitory protein to disrupt the association of CREB-binding protein and RNA polymerase II with the phosphoenolpyruvate carboxykinase gene promoterQ44031825
Cloning of the rat pyruvate dehydrogenase kinase 4 gene promoter: activation of pyruvate dehydrogenase kinase 4 by the peroxisome proliferator-activated receptor gamma coactivatorQ46557750
FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expressionQ46955933
Identification of ERRalpha as a specific partner of PGC-1alpha for the activation of PDK4 gene expression in muscle.Q51499677
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma.Q51915435
The Phosphoenolpyruvate Carboxykinase Gene Glucocorticoid Response Unit: Identification of the Functional Domains of Accessory Factors HNF3β (Hepatic Nuclear Factor-3β) and HNF4 and the Necessity of Proper Alignment of Their Cognate Binding SitesQ58511709
Further Characterization of the Glucocorticoid Response Unit in the Phosphoenolpyruvate Carboxykinase Gene. The Role of the Glucocorticoid Receptor-Binding SitesQ58511761
Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissuesQ73043566
P433issue1-2
P304page(s)159-167
P577publication date2009-08-22
P1433published inMolecular and Cellular EndocrinologyQ1573600
P1476titleRegulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin
P478volume315

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