LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations

scientific article published on August 19, 2010

LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1029334059
P356DOI10.1038/LEU.2010.163
P953full work available at URLhttps://www.nature.com/articles/leu2010163.pdf
https://www.nature.com/articles/leu2010163
P698PubMed publication ID20724988
P5875ResearchGate publication ID45721330

P50authorAyalew TefferiQ66370740
P2093author name stringS. T. Oh
C. Finke
A. Pardanani
T. Lasho
J. Gotlib
P2860cites workJournal of Clinical InvestigationQ3186904
The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changesQ22299206
Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathwaysQ28306960
Lnk constrains myeloproliferative diseases in miceQ33882944
Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms.Q34074931
Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemiasQ34162729
TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosisQ36303447
Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesisQ36402414
JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trialsQ36946580
Clinical correlates of JAK2V617F presence or allele burden in myeloproliferative neoplasms: a critical reappraisalQ37170349
Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617FQ37232941
Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disordersQ41974528
IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms.Q43089505
MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patientsQ44008600
Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation.Q51761197
Prevalence and clinicopathologic correlates of JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera.Q53544139
The JAK2 46/1 haplotype confers susceptibility to essential thrombocythemia regardless of JAK2V617F mutational status-clinical correlates in a study of 226 consecutive patients.Q54713883
Bone marrow JAK2V617F allele burden and clinical correlates in polycythemia veraQ80258200
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)1713-1718
P577publication date2010-08-19
P1433published inLeukemiaQ6534498
P1476titleLNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations
P478volume24

Reverse relations

cites work (P2860)
Q3600536214-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells
Q90628971A conditional inducible JAK2V617F transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression
Q36907588A nonsynonymous LNK polymorphism associated with idiopathic erythrocytosis
Q34166859Annual Clinical Updates in Hematological Malignancies: a continuing medical education series: polycythemia vera and essential thrombocythemia: 2011 update on diagnosis, risk-stratification, and management
Q38014534BCR-ABL1-negative chronic myeloid neoplasms: an update on management techniques
Q26777265Blast transformation and fibrotic progression in polycythemia vera and essential thrombocythemia: a literature review of incidence and risk factors
Q38844669Blast-phase myeloproliferative neoplasms: risk factors and treatment approaches
Q35217865Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia
Q83640566Clonal hierarchy and allelic mutation segregation in a myelofibrosis patient with two distinct LNK mutations
Q33595912Comparison of the Mutational Profiles of Primary Myelofibrosis, Polycythemia Vera, and Essential Thrombocytosis
Q36776428Comprehensive review of JAK inhibitors in myeloproliferative neoplasms.
Q27853179Correlation of mutation profile and response in patients with myelofibrosis treated with ruxolitinib
Q34302770Current outlook on molecular pathogenesis and treatment of myeloproliferative neoplasms
Q92005886DLGAP1 directs megakaryocytic growth and differentiation in an MPL dependent manner in hematopoietic cells
Q37955142Environmental, lifestyle, and familial/ethnic factors associated with myeloproliferative neoplasms
Q36174146Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia
Q38066786Genetic and epigenetic alterations of myeloproliferative disorders
Q26823651Genetics of myeloproliferative neoplasms
Q26770330Genomic diversity in myeloproliferative neoplasms: focus on myelofibrosis
Q26829976Genomic profiling of B-progenitor acute lymphoblastic leukemia
Q38046648Hematopoietic stem cells, progenitor cells and leukemic stem cells in adult myeloproliferative neoplasms
Q35835653IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: clinical evidence for leukemogenic collaboration with JAK2V617F
Q34348505Identification of submicroscopic genetic changes and precise breakpoint mapping in myelofibrosis using high resolution mate-pair sequencing
Q36842989Increased likelihood of post-polycythemia vera myelofibrosis in Ph-negative MPN patients with chromosome 12 abnormalities
Q42583762Infrequent occurrence of mutations in the PH domain of LNK in patients with JAK2 mutation-negative 'idiopathic' erythrocytosis
Q38127417Inherited predisposition to myeloproliferative neoplasms
Q33697252Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis
Q34150008JAK inhibitor therapy for myelofibrosis: critical assessment of value and limitations
Q26782539JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indications
Q34641224JAK/STAT signaling in hematological malignancies.
Q34652224JAK2 V617F genotype is a strong determinant of blast transformation in primary myelofibrosis
Q38044736JAK2 inhibitors in the treatment of myeloproliferative neoplasms.
Q37950581JAK2 inhibitors: are they the solution?
Q38667486LNK mutations and myeloproliferative disorders
Q64052024LNK suppresses interferon signaling in melanoma
Q37409325Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling
Q50860383Lnk prevents inflammatory CD8⁺ T-cell proliferation and contributes to intestinal homeostasis.
Q36366973Molecular analyses of 15,542 patients with suspected BCR-ABL1-negative myeloproliferative disorders allow to develop a stepwise diagnostic workflow
Q38050756Molecular biology of Philadelphia-negative myeloproliferative neoplasms
Q37555785Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms
Q54518446Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms.
Q43109584Mutational analysis of SH2B3 in Korean patients with BCR-ABL1 negative myeloproliferative neoplasm
Q54574818Mutations galore in myeloproliferative neoplasms: would the real Spartacus please stand up?
Q50072000Mutations in myeloproliferative neoplasms - their significance and clinical use.
Q27000577Myeloid malignancies: mutations, models and management
Q38046320Myeloproliferative neoplasm animal models
Q37877727Myeloproliferative neoplasms 5 years after discovery of JAK2V617F: what is the impact of JAK2 inhibitor therapy?
Q38613880Myeloproliferative neoplasms: A decade of discoveries and treatment advances
Q34629928Myeloproliferative neoplasms: from JAK2 mutations discovery to JAK2 inhibitor therapies
Q36909019Normal and malignant megakaryopoiesis
Q33997280Octa-arginine mediated delivery of wild-type Lnk protein inhibits TPO-induced M-MOK megakaryoblastic leukemic cell growth by promoting apoptosis
Q26779960Pathogenesis of Myeloproliferative Neoplasms: Role and Mechanisms of Chronic Inflammation
Q26799656Pathogenesis of myeloproliferative neoplasms
Q38926804Prognosis of Primary Myelofibrosis in the Genomic Era
Q38740198Recurring mutations in myeloproliferative neoplasms alter epigenetic regulation of gene expression
Q38046319Role of TET2 and ASXL1 mutations in the pathogenesis of myeloproliferative neoplasms
Q38050407Role of the adaptor protein LNK in normal and malignant hematopoiesis
Q92528596Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation
Q38100790Ruxolitinib: a potent and selective Janus kinase 1 and 2 inhibitor in patients with myelofibrosis. An update for clinicians
Q36901651SH2B3 (LNK) mutations from myeloproliferative neoplasms patients have mild loss of function against wild type JAK2 and JAK2 V617F.
Q33393587Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis
Q39083031Sequential analysis of 18 genes in polycythemia vera and essential thrombocythemia reveals an association between mutational status and clinical outcome.
Q36784523Splenic extramedullary hematopoietic proliferation in Philadelphia chromosome-negative myeloproliferative neoplasms: heterogeneous morphology and cytological composition.
Q89776742Targeted deep sequencing in polycythemia vera and essential thrombocythemia
Q48302310Targeted next-generation sequencing identified novel mutations in triple-negative myeloproliferative neoplasms
Q36364763The Clinical Significance of IDH Mutations in Essential Thrombocythemia and Primary Myelofibrosis
Q38044625The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis
Q35998214The Polymorphisms in LNK Gene Correlated to the Clinical Type of Myeloproliferative Neoplasms
Q64085216The Role of New Technologies in Myeloproliferative Neoplasms
Q38683077The evolution and clinical relevance of prognostic classification systems in myelofibrosis
Q39292396The role of LNK/SH2B3 genetic alterations in myeloproliferative neoplasms and other hematological disorders
Q28082685The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control
Q37968531Transformation of a chronic myeloproliferative neoplasm to acute myelogenous leukemia: does anything work?
Q44890063Type and location of isocitrate dehydrogenase mutations influence clinical characteristics and disease outcome of acute myeloid leukemia
Q41418744Unraveling the genetic underpinnings of myeloproliferative neoplasms and understanding their effect on disease course and response to therapy: proceedings from the 6th International Post-ASH Symposium
Q42870230Uses and abuses of JAK2 and MPL mutation tests in myeloproliferative neoplasms a paper from the 2010 William Beaumont hospital symposium on molecular pathology
Q39788785When the Brakes are Lost: LNK Dysfunction in Mice, Men, and Myeloproliferative Neoplasms

Search more.