The accessory subunit B of DNA polymerase gamma is required for mitochondrial replisome function

scientific article published on 23 January 2007

The accessory subunit B of DNA polymerase gamma is required for mitochondrial replisome function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKL1116
P8608Fatcat IDrelease_ypdjeicldvgcngkumvi5cb6kgq
P932PMC publication ID1807957
P698PubMed publication ID17251196
P5875ResearchGate publication ID6552869

P50authorMaria FalkenbergQ60379390
P2093author name stringTeresa Holmlund
Géraldine Farge
Xuan Hoi Pham
Ivan Khorostov
P2860cites workFunctional human mitochondrial DNA polymerase gamma forms a heterotrimerQ24293340
Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzymeQ24321839
TWINKLE Has 5' -> 3' DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding proteinQ24323366
Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegiaQ24546476
The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cellsQ24559899
Reconstitution of a minimal mtDNA replisome in vitroQ24564147
DNA sequence analysis with a modified bacteriophage T7 DNA polymeraseQ24605322
Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase gamma, Pol gamma B, functions as a homodimerQ27629468
Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondriaQ28204177
The accessory subunit of Xenopus laevis mitochondrial DNA polymerase gamma increases processivity of the catalytic subunit of human DNA polymerase gamma and is related to class II aminoacyl-tRNA synthetasesQ33651720
A unique loop in T7 DNA polymerase mediates the binding of helicase-primase, DNA binding protein, and processivity factorQ33935984
Human mitochondrial topoisomerase IQ33943662
DNA binding properties of human pol gammaB.Q34154437
Bacteriophage origins of mitochondrial replication and transcription proteinsQ34477855
Leading and lagging strand DNA synthesis in vitro by a reconstituted herpes simplex virus type 1 replisomeQ35665398
DNA polymerase gamma, the mitochondrial replicaseQ35799966
A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymeraseQ36435827
3' to 5' exonuclease activity of herpes simplex virus type 1 DNA polymerase modulates its strand displacement activityQ36464280
The Acidic Carboxyl Terminus of the Bacteriophage T7 Gene 4 Helicase/Primase Interacts with T7 DNA PolymeraseQ38344156
Mitochondrial DNA maintenance in vertebratesQ40912243
Twinkle, the mitochondrial replicative DNA helicase, is widespread in the eukaryotic radiation and may also be the mitochondrial DNA primase in most eukaryotesQ42683184
Interaction of mutant thioredoxins of Escherichia coli with the gene 5 protein of phage T7. The redox capacity of thioredoxin is not required for stimulation of DNA polymerase activity.Q54773032
The effect of the T7 and Escherichia coli DNA-binding proteins at the replication fork of bacteriophage T7Q69830561
Exonuclease proofreading by human mitochondrial DNA polymeraseQ74285113
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)902-911
P577publication date2007-01-23
P1433published inNucleic Acids ResearchQ135122
P1476titleThe accessory subunit B of DNA polymerase gamma is required for mitochondrial replisome function
P478volume35

Reverse relations

cites work (P2860)
Q34107395A single mutation in human mitochondrial DNA polymerase Pol gammaA affects both polymerization and proofreading activities of only the holoenzyme
Q35090101Biochemical analysis of human POLG2 variants associated with mitochondrial disease.
Q34202934C-terminal extension of the yeast mitochondrial DNA polymerase determines the balance between synthesis and degradation
Q36638620Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies
Q33569793Each monomer of the dimeric accessory protein for human mitochondrial DNA polymerase has a distinct role in conferring processivity
Q35922647Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicase
Q38649815Inherited mitochondrial genomic instability and chemical exposures
Q34528068MGME1 processes flaps into ligatable nicks in concert with DNA polymerase γ during mtDNA replication
Q33560901Mitochondrial DNA replication: a PrimPol perspective
Q92562059Mitochondrial fusion is required for regulation of mitochondrial DNA replication
Q84689191POLG exon 22 skipping induced by different mechanisms in two unrelated cases of Alpers syndrome
Q37785515Polymerase gamma disease through the ages
Q26797996Primer removal during mammalian mitochondrial DNA replication
Q46690178RECQL4 and p53 potentiate the activity of polymerase γ and maintain the integrity of the human mitochondrial genome
Q60921976RNase H1 directs origin-specific initiation of DNA replication in human mitochondria
Q64278410RNase H1 promotes replication fork progression through oppositely transcribed regions of mitochondrial DNA
Q42117981Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element.
Q38824997Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases
Q34811598SLC25A4 and C10ORF2 Mutations in Autosomal Dominant Progressive External Ophthalmoplegia
Q24336678Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations
Q37824054Structural insight on processivity, human disease and antiviral drug toxicity
Q37385875The accessory subunit of mitochondrial DNA polymerase gamma determines the DNA content of mitochondrial nucleoids in human cultured cells
Q41883034The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication.
Q24627299The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis

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