Mitochondrial fusion is required for regulation of mitochondrial DNA replication

scientific article published on 06 June 2019

Mitochondrial fusion is required for regulation of mitochondrial DNA replication is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1008085
P932PMC publication ID6553695
P698PubMed publication ID31170154

P50authorNils-Göran LarssonQ5938385
Stefan JakobsQ28355517
Kjell HultenbyQ28468914
Bianca HabermannQ30504194
Arnaud MourierQ56944202
Inge KühlQ57511218
Eduardo Silva RamosQ58527426
Assa YeroslavizQ63679449
Benedetta RuzzenenteQ88166316
Christian BrüserQ92562054
Elisa MotoriQ99407800
Johanna H K KauppilaQ125252094
P2093author name stringJakob D Busch
P2860cites workOPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28Q24290356
Control of mitochondrial morphology by a human mitofusinQ24290831
LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAsQ24295176
Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins.Q24541558
Reconstitution of a minimal mtDNA replisome in vitroQ24564147
Gene Expression Omnibus: NCBI gene expression and hybridization array data repositoryQ27860523
Fast gapped-read alignment with Bowtie 2Q27860699
The Sequence Alignment/Map format and SAMtoolsQ27860966
Mitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynaminQ27934616
Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiaeQ27935307
ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeastQ27935426
The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondriaQ27938333
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophyQ28140286
Mutation spectrum and splicing variants in the OPA1 geneQ28216607
Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy numberQ28290165
Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenanceQ28510356
Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesisQ28511104
In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replicationQ28542495
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic developmentQ28594513
Fast and accurate long-read alignment with Burrows-Wheeler transformQ29547193
Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2AQ29616547
Disruption of fusion results in mitochondrial heterogeneity and dysfunctionQ29616566
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in miceQ29617092
ER tubules mark sites of mitochondrial divisionQ29619991
Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c.Q30541662
Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence.Q33773474
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutationsQ33877979
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in miceQ34201844
Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels.Q35094282
Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA.Q35170688
Mitochondrial fusion is essential for organelle function and cardiac homeostasisQ35613447
Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoidQ35754971
Scalable Isolation of Mammalian Mitochondria for Nucleic Acid and Nucleoid AnalysisQ35831104
Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heartQ36455449
Two-dimensional intact mitochondrial DNA agarose electrophoresis reveals the structural complexity of the mammalian mitochondrial genome.Q36619848
TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replicationQ36787217
Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletionQ36860874
OPA1 mutations and mitochondrial DNA damage: keeping the magic circle in shapeQ37068436
POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA.Q37155771
The dynamin-related GTPase Drp1 is required for embryonic and brain development in miceQ37365414
Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.Q51760035
A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy.Q52137131
Overexpression of the catalytic subunit of DNA polymerase gamma results in depletion of mitochondrial DNA in Drosophila melanogaster.Q52583090
POLRMT does not transcribe nuclear genes.Q54316761
Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual functionQ80146686
ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cellsQ38758060
Maintenance and Expression of Mammalian Mitochondrial DNA.Q38792624
Loss of LRPPRC causes ATP synthase deficiencyQ38806341
Superresolution fluorescence imaging of mitochondrial nucleoids reveals their spatial range, limits, and membrane interactionQ39665381
Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondriaQ40763148
MtDNA-maintenance defects: syndromes and genesQ40955181
A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loopQ41517167
Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart developmentQ41888127
The accessory subunit B of DNA polymerase gamma is required for mitochondrial replisome functionQ42942782
Subnormal levels of POLγA cause inefficient initiation of light-strand DNA synthesis and lead to mitochondrial DNA deletions and progressive external ophthalmoplegia [corrected].Q45852433
OPA1 Isoforms in the Hierarchical Organization of Mitochondrial Functions.Q46398821
Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA.Q47228285
Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammalsQ47408311
The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structureQ47948450
Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neuronsQ48401711
Early onset severe and late-onset mild Charcot-Marie-Tooth disease with mitofusin 2 (MFN2) mutationsQ48474475
The MFN2 gene is responsible for mitochondrial DNA instability and optic atrophy 'plus' phenotype.Q48762457
SnapShot: Mitochondrial NucleoidQ50065273
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)e1008085
P577publication date2019-06-06
P1433published inPLOS GeneticsQ1893441
P1476titleMitochondrial fusion is required for regulation of mitochondrial DNA replication
P478volume15

Reverse relations

cites work (P2860)
Q93103041Functional Interplay between Cristae Biogenesis, Mitochondrial Dynamics and Mitochondrial DNA Integrity
Q92970985MSTO1 mutations cause mtDNA depletion, manifesting as muscular dystrophy with cerebellar involvement
Q96954758Mitochondrial Function in Muscle Stem Cell Fates
Q99407805Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction

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