The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure

scientific article published on 15 March 2017

The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M116.762567
P932PMC publication ID5409478
P698PubMed publication ID28298442

P2093author name stringYisang Yoon
Sylvia B Smith
Hakjoo Lee
P2860cites workOPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28Q24290356
Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cellsQ24291591
Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphologyQ24292310
Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cellsQ24293452
Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane spaceQ24298363
YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferationQ24302280
OPA1 cleavage depends on decreased mitochondrial ATP level and bivalent metalsQ81161420
OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypesQ24304868
Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2Q24305114
C11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilizationQ24315727
Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosisQ24338169
OPA1 requires mitofusin 1 to promote mitochondrial fusionQ24560014
Multi-system neurological disease is common in patients with OPA1 mutationsQ24619312
Prohibitin 2: At a communications crossroadsQ26825374
Decreasing mitochondrial fission diminishes vascular smooth muscle cell migration and ameliorates intimal hyperplasiaQ27302132
Oma1, a novel membrane-bound metallopeptidase in mitochondria with activities overlapping with the m-AAA proteaseQ27931615
Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins.Q27934000
Prohibitins regulate membrane protein degradation by the m-AAA protease in mitochondriaQ27934696
Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1.Q27936009
Multifaceted role of prohibitin in cell survival and apoptosisQ28087391
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophyQ28140286
The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane spaceQ28215023
Mutation spectrum and splicing variants in the OPA1 geneQ28216607
Dynamin-like protein 1 is involved in peroxisomal fissionQ28218956
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fissionQ28235694
The Prohibitins: emerging roles in diverse functionsQ28248077
OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demandQ28249429
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusionQ28251846
The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damageQ28262786
Blue native PAGEQ28296330
Regulation of mitochondrial morphology through proteolytic cleavage of OPA1Q28571639
Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1Q28594164
SLP-2 is required for stress-induced mitochondrial hyperfusionQ28594182
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic developmentQ28594513
Disruption of fusion results in mitochondrial heterogeneity and dysfunctionQ29616566
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability.Q29616569
Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerizationQ30485835
Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusionQ30489225
Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamicsQ30491358
OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulationQ30494366
Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicityQ30532888
Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylationQ30578089
Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylationQ33599185
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutationsQ33877979
Mammalian dynamin-like protein DLP1 tubulates membranesQ33946794
AAA proteases of mitochondria: quality control of membrane proteins and regulatory functions during mitochondrial biogenesisQ34332387
Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphologyQ34479807
Mitochondrial dynamics in diabetesQ34511749
A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver.Q34526585
Mitochondrial threshold effects.Q35017647
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvationQ35064216
The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cellsQ35083432
Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysisQ35101307
Opa1 overexpression ameliorates the phenotype of two mitochondrial disease mouse models.Q35689631
Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cellsQ35754670
Selective Oma1 protease-mediated proteolysis of Cox1 subunit of cytochrome oxidase in assembly mutantsQ35801928
Mitochondrial diseases and ATPase defects of nuclear origin.Q35849777
Mitochondrial complex I plays an essential role in human respirasome assemblyQ35868845
Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxiaQ35990125
Perspectives on: SGP symposium on mitochondrial physiology and medicine: what comes first, misshape or dysfunction? The view from metabolic excessQ35995740
Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex StabilityQ36056367
Regulation of mitochondrial dynamics: another process modulated by Ca2+ signals?Q36102553
OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L.Q36119045
Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavageQ36119051
Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondriaQ36453541
Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiencyQ37215027
Stress-regulated translational attenuation adapts mitochondrial protein import through Tim17A degradation.Q37524374
Prohibitins and the functional compartmentalization of mitochondrial membranes.Q37627477
Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular FunctionQ38669205
Cell survival during complete nutrient deprivation depends on lipid droplet-fueled β-oxidation of fatty acidsQ39111042
Respiratory active mitochondrial supercomplexes.Q39913363
Structural basis of mitochondrial tethering by mitofusin complexes.Q40527845
Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondriaQ44768454
OPA1 functionally interacts with MIC60 but is dispensable for crista junction formation.Q51537419
Threshold effect and tissue specificity. Implication for mitochondrial cytopathiesQ73176064
OPA1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted function in apoptosisQ79196601
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)7115-7130
P577publication date2017-03-15
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure
P478volume292

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cites work (P2860)
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Q91776836Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1
Q89900069The anti-viral dynamin family member MxB participates in mitochondrial integrity

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