Characterisation of Foxp3 splice variants in human CD4+ and CD8+ T cells—Identification of Foxp3Δ7 in human regulatory T cells

scientific article published on August 5, 2010

Characterisation of Foxp3 splice variants in human CD4+ and CD8+ T cells—Identification of Foxp3Δ7 in human regulatory T cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.MOLIMM.2010.07.008
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0161589010005201?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0161589010005201?httpAccept=text/plain
P698PubMed publication ID20688398

P50authorJane GoodallQ57195861
P2093author name stringGurman Kaur
J. S. Hill Gaston
Lorna B. Jarvis
P2860cites workDisruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouseQ24290693
FOXP3 controls regulatory T cell function through cooperation with NFATQ24298179
Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cellsQ24298812
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repressionQ24300168
Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressorQ24300325
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1Q24300625
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cellsQ24306205
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat functionQ24314628
Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3Q24315715
Foxp3 occupancy and regulation of key target genes during T-cell stimulationQ24623384
JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndromeQ24626901
Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cellsQ24645614
Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammatQ39988736
Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3.Q40055892
FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease.Q40116369
Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine productionQ40165347
Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells.Q40339083
Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.Q40801370
The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.Q41998069
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivoQ42139164
Molecular mechanisms underlying FOXP3 induction in human T cellsQ42491664
Regulatory T cell development in the absence of functional Foxp3.Q44440268
Alloantigen specific CD8+CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivityQ47265853
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.Q51997055
IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.Q51998742
DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.Q52924279
Autoreactive human peripheral blood CD8+ T cells with a regulatory phenotype and function.Q54641462
Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.Q54645452
Human leukocyte antigen class I-restricted immunosuppression by human CD8+ regulatory T cells requires CTLA-4-mediated interaction with dendritic cellsQ56900343
Transient expression of FOXP3 in human activated nonregulatory CD4+ T cellsQ58234949
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expressionQ59048389
Foxp3-dependent programme of regulatory T-cell differentiationQ59084714
Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell levelQ60311694
Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional SignatureQ61713917
Splice variants of human FOXP3 are functional inhibitors of human CD4+ T-cell activationQ79147744
Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4(+)CD25(-) cellsQ81083994
Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted miceQ84925181
Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndromeQ24679039
HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cellsQ24802813
Control of regulatory T cell development by the transcription factor Foxp3Q27860489
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3Q28116303
The amount of scurfin protein determines peripheral T cell number and responsivenessQ28504592
Regulatory T cell lineage specification by the forkhead transcription factor foxp3Q28510328
Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7Q28591451
An essential role for Scurfin in CD4+CD25+ T regulatory cellsQ29618395
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfyQ29619109
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3Q29619324
Epigenetic control of the foxp3 locus in regulatory T cellsQ33273617
FOXP3 promoter demethylation reveals the committed Treg population in humans.Q33320522
The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndromeQ33404650
Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the peripheryQ33414811
Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3Q33517120
c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cellsQ33590483
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cellsQ33810601
De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cellsQ33932462
Five years on the wings of fork headQ34398426
Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells.Q34529123
FOXP3 and NFAT: partners in toleranceQ34551714
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell developmentQ34597933
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancerQ34729938
Nonredundant roles for Stat5a/b in directly regulating Foxp3Q35828667
X-linked lymphoreticular disease in the scurfy (sf) mutant mouseQ35831357
Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotypeQ36059631
CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation.Q36229540
FOXP3: of mice and men.Q36427333
Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cellsQ37394198
Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic educationQ37537286
AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.Q37636349
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.Q38305613
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like diseaseQ38306073
CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cellsQ39333442
P433issue1-3
P407language of work or nameEnglishQ1860
P304page(s)321-332
P577publication date2010-08-05
P1433published inMolecular ImmunologyQ6895954
P1476titleCharacterisation of Foxp3 splice variants in human CD4+ and CD8+ T cells--identification of Foxp3Δ7 in human regulatory T cells
Characterisation of Foxp3 splice variants in human CD4+ and CD8+ T cells—Identification of Foxp3Δ7 in human regulatory T cells
P478volume48

Reverse relations

cites work (P2860)
Q38779090Activation-dependent mitochondrial translocation of Foxp3 in human hepatocytes
Q55495606Alternative Splicing of FOXP3-Virtue and Vice.
Q52966824C-terminal cleavage of human Foxp3 at a proprotein convertase motif abrogates its suppressive function.
Q38319204ChIP-on-chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells
Q36751866Control of alternative splicing in immune responses: many regulators, many predictions, much still to learn
Q34778974Dissecting the role of the FOXP3 gene in the joint genetic susceptibility to autoimmune thyroiditis and diabetes: a genetic and functional analysis
Q36904140Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants
Q35206452Inactivation of X-linked tumor suppressor genes in human cancer
Q46439239Metabolic pressure and the breach of immunological self-tolerance.
Q38439401Metabolism of murine TH 17 cells: Impact on cell fate and function
Q92757833One, No One, and One Hundred Thousand: T Regulatory Cells' Multiple Identities in Neuroimmunity
Q58574940Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes
Q45846238Regulatory T cell proliferative potential is impaired in human autoimmune disease
Q38957379Role of Metabolism in the Immunobiology of Regulatory T Cells
Q24337573Subcellular localization of FOXP3 in human regulatory and nonregulatory T cells
Q90176770The Impact of Dietary Components on Regulatory T Cells and Disease
Q37864831The dual role of the X-linked FoxP3 gene in human cancers
Q48010811The regulation of immune tolerance by FOXP3.

Search more.