Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection

scientific article published on September 2003

Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20022058
P932PMC publication ID2194204
P698PubMed publication ID12975456
P5875ResearchGate publication ID10567210

P50authorAlan Bernard RickinsonQ21165006
Andrew James McMichaelQ21165187
P2093author name stringChris Hatton
Damien Montamat-Sicotte
Margaret F C Callan
Elisabeth Amyes
Nancy Gudgeon
P2860cites workTwo subsets of memory T lymphocytes with distinct homing potentials and effector functionsQ28146072
Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletionQ28511040
Long-term CD4 Th1 and Th2 memory following acute lymphocytic choriomeningitis virus infectionQ33784950
CD27 is required for generation and long-term maintenance of T cell immunityQ33924191
A simple reverse transcriptase PCR assay to distinguish EBNA1 gene transcripts associated with type I and II latency from those arising during induction of the viral lytic cycleQ35872919
Massive expansion of antigen-specific CD8+ T cells during an acute virus infectionQ37419599
Differential immunogenicity of Epstein-Barr virus latent-cycle proteins for human CD4(+) T-helper 1 responsesQ39607047
Development of virus-specific CD4(+) T cells during primary cytomegalovirus infectionQ40309482
Large clonal expansions of CD8+ T cells in acute infectious mononucleosisQ40665903
CD8(+) T-cell selection, function, and death in the primary immune response in vivoQ40735898
Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivoQ41764334
Epitope-specific evolution of human CD8(+) T cell responses from primary to persistent phases of Epstein-Barr virus infectionQ42175278
Phenotypic and functional separation of memory and effector human CD8+ T cellsQ42951823
Differential evolution and stability of epitope-specific CD8(+) T cell responses in EBV infectionQ44381226
A re-evaluation of the frequency of CD8+ T cells specific for EBV in healthy virus carriers.Q44952697
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infectionsQ45733084
Variable fate of virus-specific CD4(+) T cells during primary HIV-1 infectionQ45734459
Stability of virus-specific CD4+ T cell frequencies from acute infection into long term memory.Q45755193
Detection of antigen-specific T cell cytokine expression in whole blood by flow cytometryQ47815571
Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease.Q52009673
Analysis of HIV-1- and CMV-specific memory CD4 T-cell responses during primary and chronic infection.Q52011379
Differentiation of human CD8(+) T cells from a memory to memory/effector phenotype.Q52012681
Evidence that human CD8+CD45RA+CD27- cells are induced by antigen and evolve through extensive rounds of division.Q52033319
Differentiation of human CD8 T cells: implications for in vivo persistence of CD8+ CD28- cytotoxic effector clones.Q52035114
Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.Q52040367
CD28- T lymphocytes. Antigenic and functional properties.Q52065463
Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memoryQ56904820
Regulation of CD27 expression on subsets of mature T-lymphocytesQ72092935
Differential kinetics and specificity of EBV-specific CD4+ and CD8+ T cells during primary infectionQ73020177
Class I processing-defective Burkitt's lymphoma cells are recognized efficiently by CD4+ EBV-specific CTLsQ73224609
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectEpstein–Barr virusQ6900
P304page(s)903-911
P577publication date2003-09-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleCharacterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection
P478volume198

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cites work (P2860)
Q60321325A TGF-β mediated regulatory mechanism modulates the T cell immune response to rotavirus in adults but not in children
Q42202658A mutation in X-linked inhibitor of apoptosis (G466X) leads to memory inflation of Epstein-Barr virus-specific T cells
Q36084979A profile of immune response to herpesvirus is associated with radiographic joint damage in rheumatoid arthritis.
Q36228210Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation
Q42229225Age-associated Epstein-Barr virus-specific T cell responses in seropositive healthy adults.
Q37644275Analysis of the cross-talk of Epstein-Barr virus-infected B cells with T cells in the marmoset
Q40254337Assessment of CD8(+) T cell differentiation in Trypanosoma cruzi-infected children
Q37178988Broadened and elevated humoral immune response to EBNA1 in pediatric multiple sclerosis
Q35101557CD127+CCR5+CD38+++ CD4+ Th1 effector cells are an early component of the primary immune response to vaccinia virus and precede development of interleukin-2+ memory CD4+ T cells
Q36722596CD27 expression discriminates porcine T helper cells with functionally distinct properties.
Q51996932CD27- CD4+ memory T cells define a differentiated memory population at both the functional and transcriptional levels.
Q35216907CD4+ T cells from elite suppressors are more susceptible to HIV-1 but produce fewer virions than cells from chronic progressors
Q43761729Cerebrospinal fluid CD4+ T cells from a multiple sclerosis patient cross-recognize Epstein-Barr virus and myelin basic protein
Q51889875Characteristics of expanded CD4+CD28null T cells in patients with chronic hepatitis B.
Q51968740Characterization of a subset of antigen-specific human central memory CD4+ T lymphocytes producing effector cytokines.
Q51764698Checks and Balances in Autoimmune Vasculitis.
Q44549769Computer-Aided Design of an Epitope-Based Vaccine against Epstein-Barr Virus.
Q30300254Cytomegalovirus infection enhances the immune response to influenza.
Q21296742Cytotoxic CD4 T cells in antiviral immunity
Q42066029Cytotoxic CD4+ T cell responses to EBV contrast with CD8 responses in breadth of lytic cycle antigen choice and in lytic cycle recognition
Q36415765Decimated or missing in action: CD4+ T cells as targets and effectors in the pathogenesis of primary HIV infection
Q39170011Designing an effective vaccine to prevent Epstein-Barr virus-associated diseases: challenges and opportunities
Q44615180Detailed analysis of Epstein-Barr virus-specific CD4+ and CD8+ T cell responses during infectious mononucleosis
Q36082304Differences in antigen-specific CD4+ responses to opportunistic infections in HIV infection
Q41605285Differences in systemic adaptive immunity contribute to the 'frequent exacerbator' COPD phenotype
Q34062231Direct ex-vivo evaluation of pneumococcal specific T-cells in healthy adults
Q34251506Dissection of regenerating T-Cell responses against tuberculosis in HIV-infected adults sensitized by Mycobacterium tuberculosis
Q35616090Distinct memory CD4+ T-cell subsets mediate immune recognition of Epstein Barr virus nuclear antigen 1 in healthy virus carriers
Q42235412Donor-derived CD4(+)/CCR7(+) T-cell partial selective depletion does not alter acquired anti-infective immunity.
Q24657388EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-gamma and IL-2
Q34186560EBV-specific CD8+ T cells from asymptomatic pediatric thoracic transplant patients carrying chronic high EBV loads display contrasting features: activated phenotype and exhausted function
Q31108462Effect of natalizumab on circulating CD4+ T-cells in multiple sclerosis
Q35798450Effects of Sleep Fragmentation and Chronic Latent Viral Infection on Behavior and Inflammation in Mice
Q35964751Epidemiology, pathogenesis and prevention of congenital cytomegalovirus infection
Q34227303Epstein-Barr virus infection and clinical outcome in breast cancer patients correlate with immune cell TNF-α/IFN-γ response
Q35891748Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide
Q36452614Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases.
Q36529008Functional signatures of protective antiviral T-cell immunity in human virus infections.
Q36591344Generation and maintenance of human memory cells during viral infection.
Q33280133HIV patients developing primary CNS lymphoma lack EBV-specific CD4+ T cell function irrespective of absolute CD4+ T cell counts
Q40351825HLA type-independent method to monitor polyoma BK virus-specific CD4 and CD8 T-cell immunity
Q28302729Herpesvirus latency confers symbiotic protection from bacterial infection
Q35652539Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion
Q40071847Human Immunodeficiency Virus Type 1 Persistence Following Systemic Chemotherapy for Malignancy
Q39097082Human immunity against EBV-lessons from the clinic.
Q26851748Human memory T cells: generation, compartmentalization and homeostasis
Q44704847IL-15 preferentially enhances functional properties and antigen-specific responses of CD4+CD28(null) compared to CD4+CD28+ T cells
Q92151588Immune Control and Vaccination against the Epstein-Barr Virus in Humanized Mice
Q24795912Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection
Q36410689Immune control of Babesia bovis infection
Q37243692Immunophenotypic alterations in acute and early HIV infection
Q37567836Immunotherapy for HIV-associated non-Hodgkin's lymphoma.
Q55265317Impaired Control of Epstein-Barr Virus Infection in B-Cell Expansion with NF-κB and T-Cell Anergy Disease.
Q36943860Increased frequency of EBV-specific effector memory CD8+ T cells correlates with higher viral load in rheumatoid arthritis.
Q34571341Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection
Q38186778Is murine gammaherpesvirus-68 (MHV-68) a suitable immunotoxicological model for examining immunomodulatory drug-associated viral recrudescence?
Q37500069KLRG1--more than a marker for T cell senescence
Q36835155Long-term expansion of effector/memory Vdelta2-gammadelta T cells is a specific blood signature of CMV infection
Q39441043Longitudinal analysis of frequency and reactivity of Epstein-Barr virus-specific T lymphocytes and their association with intermittent viral reactivation
Q40351573Lymph node and circulating T cell characteristics are strongly correlated in end-stage renal disease patients, but highly differentiated T cells reside within the circulation.
Q40471906MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response.
Q42617680MHC class II tetramer guided detection of Mycobacterium tuberculosis-specific CD4+ T cells in peripheral blood from patients with pulmonary tuberculosis.
Q34152994Maintenance of cytomegalovirus-specific CD4pos T-cell response in rheumatoid arthritis patients receiving anti-tumor necrosis factor treatments
Q41358122Molecular mechanisms involved in the aging of the T-cell immune response.
Q35562281NKG2D expression in CD4+ T lymphocytes as a marker of senescence in the aged immune system.
Q37888687Natural and adoptive T-cell immunity against herpes family viruses after allogeneic hematopoietic stem cell transplantation
Q45508924Novel method for detection of virus-specific CD41+ T cells indicates a decreased EBV-specific CD4+ T cell response in untreated HIV-infected subjects
Q36273291Overcoming the memory barrier in tolerance induction: molecular mimicry and functional heterogeneity among pathogen-specific T-cell populations
Q33539769Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells
Q37034639Perspectives for a protective HIV-1 vaccine
Q37266382Phenotype and function of human T lymphocyte subsets: consensus and issues
Q36577650Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection
Q91900147Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T Cells
Q37049038Primer: making sense of T-cell memory.
Q36143186Reduced Plasmodium Parasite Burden Associates with CD38+ CD4+ T Cells Displaying Cytolytic Potential and Impaired IFN-γ Production
Q42723067Regression of Epstein-Barr virus-induced B-cell transformation in vitro involves virus-specific CD8+ T cells as the principal effectors and a novel CD4+ T-cell reactivity
Q35853687Relationship between functional ability in older people, immune system status, and intensity of response to CMV
Q36407109Repertoire and frequency of immune cells reactive to Epstein-Barr virus-derived autologous lymphoblastoid cell lines
Q40303777Selection of Epstein-Barr virus specific cytotoxic T lymphocytes can be performed with B lymphoblastoid cell lines created in serum-free media
Q44972601T cell phenotypes in patients with common variable immunodeficiency disorders: associations with clinical phenotypes in comparison with other groups with recurrent infections
Q36238129T cells and viral persistence: lessons from diverse infections
Q47120971T-Cell Composition of the Lymph Node Is Associated with the Risk for Early Rejection after Renal Transplantation.
Q38597252T-Cell Responses to EBV.
Q39219487The Immune Response to Epstein Barr Virus and Implications for Posttransplant Lymphoproliferative Disorder
Q34642996The T-cell response to HIV.
Q34400561The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation
Q80576888The physiological role of cytotoxic CD4(+) T-cells: the holy grail?
Q37070576Toward a genetics of cancer resistance
Q35891788Transient immunological control during acute hepatitis C virus infection: ex vivo analysis of helper T-cell responses
Q34434702Virus and cell RNAs expressed during Epstein-Barr virus replication
Q90715981Virus-specific T cells in pediatric renal transplantation
Q40602726When Aging Reaches CD4+ T-Cells: Phenotypic and Functional Changes
Q36604777Why can't the immune system control HIV-1? Defining HIV-1-specific CD4+ T cell immunity in order to develop strategies to enhance viral immunity

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