The physiological role of cytotoxic CD4(+) T-cells: the holy grail?

scientific article published on 01 October 2004

The physiological role of cytotoxic CD4(+) T-cells: the holy grail? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.1365-2249.2004.02605.X
P932PMC publication ID1809194
P698PubMed publication ID15373899

P2093author name stringAppay V
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Functional subsets of CD4 T cells in rheumatoid synovitisQ77742322
Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infectionQ79330614
CD4 T cells producing IFN-gamma in the lungs of mice challenged with mycobacteria express a CD27-negative phenotypeQ80576892
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Prevalence, clinical relevance and characterization of circulating cytotoxic CD4+CD28- T cells in ankylosing spondylitisQ24797697
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Identification of a population of CD4+ CTL that utilizes a perforin- rather than a Fas ligand-dependent cytotoxic mechanism.Q30468152
Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation thresholdQ33715565
Lessons from the study of T-cell differentiation in persistent human virus infectionQ35766294
Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+.Q36290374
Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cellsQ36399420
Multiple effector functions mediated by human immunodeficiency virus-specific CD4(+) T-cell clonesQ39604412
A CD4+ cytotoxic T-lymphocyte clone to a conserved epitope on human immunodeficiency virus type 1 p24: cytotoxic activity and secretion of interleukin-2 and interleukin-6Q40049315
Specific lysis of targets expressing varicella-zoster virus gpI or gpIV by CD4+ human T-cell clonesQ40065177
Cutaneous T cell lymphoma reactive CD4+ cytotoxic T lymphocyte clones display a Th1 cytokine profile and use a fas-independent pathway for specific tumor cell lysis.Q40869506
Granule exocytosis, and not the fas/fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4(+) as well as CD8(+) cytotoxic T lymphocytes in humansQ40891554
Ex vivo phenotype and frequency of influenza virus-specific CD4 memory T cellsQ40909807
Individual variation in the frequency of HLA class II-specific cytotoxic T lymphocyte precursors.Q41739364
Expression of specific cytolytic activity by H-2I region-restricted, influenza virus-specific T lymphocyte clonesQ41814029
Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor.Q42062444
Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infectionQ42945184
Properties of CD4(+) T cells in human cytomegalovirus infectionQ44917514
The size and phenotype of virus-specific T cell populations is determined by repetitive antigenic stimulation and environmental cytokines.Q45643113
Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapyQ45721932
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infectionsQ45733084
T cell killing does not require the formation of a stable mature immunological synapse.Q46039675
HIV-1-specific memory CD4+ T cells are phenotypically less mature than cytomegalovirus-specific memory CD4+ T cellsQ47217936
Cytotoxic CD4+ T cells in patients with B cell chronic lymphocytic leukemia kill via a perforin-mediated pathway.Q47790401
P433issue1
P304page(s)10-13
P577publication date2004-10-01
P1433published inClinical and Experimental ImmunologyQ15716708
P1476titleThe physiological role of cytotoxic CD4(+) T-cells: the holy grail?
P478volume138

Reverse relations

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