review article | Q7318358 |
scholarly article | Q13442814 |
P2093 | author name string | Appay V | |
P2860 | cites work | Acquisition of specific cytotoxic activity by human T4+ T lymphocytes in culture | Q59097936 |
Recognition of MHC class I allodeterminants regulates the generation of MHC class II-specific CTL | Q70309576 | ||
Characterization of CD4(+) CTLs ex vivo | Q74145676 | ||
Functional subsets of CD4 T cells in rheumatoid synovitis | Q77742322 | ||
Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection | Q79330614 | ||
CD4 T cells producing IFN-gamma in the lungs of mice challenged with mycobacteria express a CD27-negative phenotype | Q80576892 | ||
Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection | Q24795912 | ||
Prevalence, clinical relevance and characterization of circulating cytotoxic CD4+CD28- T cells in ankylosing spondylitis | Q24797697 | ||
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Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+. | Q36290374 | ||
Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells | Q36399420 | ||
Multiple effector functions mediated by human immunodeficiency virus-specific CD4(+) T-cell clones | Q39604412 | ||
A CD4+ cytotoxic T-lymphocyte clone to a conserved epitope on human immunodeficiency virus type 1 p24: cytotoxic activity and secretion of interleukin-2 and interleukin-6 | Q40049315 | ||
Specific lysis of targets expressing varicella-zoster virus gpI or gpIV by CD4+ human T-cell clones | Q40065177 | ||
Cutaneous T cell lymphoma reactive CD4+ cytotoxic T lymphocyte clones display a Th1 cytokine profile and use a fas-independent pathway for specific tumor cell lysis. | Q40869506 | ||
Granule exocytosis, and not the fas/fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4(+) as well as CD8(+) cytotoxic T lymphocytes in humans | Q40891554 | ||
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Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor. | Q42062444 | ||
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The size and phenotype of virus-specific T cell populations is determined by repetitive antigenic stimulation and environmental cytokines. | Q45643113 | ||
Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy | Q45721932 | ||
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections | Q45733084 | ||
T cell killing does not require the formation of a stable mature immunological synapse. | Q46039675 | ||
HIV-1-specific memory CD4+ T cells are phenotypically less mature than cytomegalovirus-specific memory CD4+ T cells | Q47217936 | ||
Cytotoxic CD4+ T cells in patients with B cell chronic lymphocytic leukemia kill via a perforin-mediated pathway. | Q47790401 | ||
P433 | issue | 1 | |
P304 | page(s) | 10-13 | |
P577 | publication date | 2004-10-01 | |
P1433 | published in | Clinical and Experimental Immunology | Q15716708 |
P1476 | title | The physiological role of cytotoxic CD4(+) T-cells: the holy grail? | |
P478 | volume | 138 |
Q79844463 | Association between the HLA haplotype and the TCR-Vbeta repertoire of anti-hCMV specific memory T-cells in immunocompetent healthy adults |
Q36403294 | Association of Elevations of Specific T Cell and Monocyte Subpopulations in Rheumatoid Arthritis With Subclinical Coronary Artery Atherosclerosis |
Q64256617 | Cell Differentiation Degree as a Factor Determining the Role for Different T-Helper Populations in Tuberculosis Protection |
Q82538830 | Characterization of bone marrow T cells in monoclonal gammopathy of undetermined significance, multiple myeloma, and plasma cell leukemia demonstrates increased infiltration by cytotoxic/Th1 T cells demonstrating a squed TCR-Vbeta repertoire |
Q36545994 | Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion |
Q34783806 | Chronic human infection with Trypanosoma cruzi drives CD4+ T cells to immune senescence |
Q39122674 | Clonally expanded cytotoxic CD4+ T cells and the pathogenesis of IgG4-related disease |
Q30413410 | Cytokine-dependent induction of CD4+ T cells with cytotoxic potential during influenza virus infection |
Q37710793 | Cytolytic CD4 cells: Direct mediators in infectious disease and malignancy |
Q37812127 | Cytolytic CD4+T cells in viral immunity |
Q37597931 | Cytotoxic CD4 T Cells-Friend or Foe during Viral Infection? |
Q30353821 | Differential influenza H1N1-specific humoral and cellular response kinetics in kidney transplant patients. |
Q27003380 | Distinct roles of CD4+ T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model |
Q36213487 | Durable complete responses off all treatment in patients with metastatic malignant melanoma after sequential immunotherapy followed by a finite course of BRAF inhibitor therapy. |
Q47144077 | Editorial: Cytotoxic CD4+ T Cells in Viral Infections |
Q36286127 | Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability |
Q40420141 | Equine interferon gamma synthesis in lymphocytes after in vivo infection and in vitro stimulation with EHV-1. |
Q37667998 | Fighting Viral Infections and Virus-Driven Tumors with Cytotoxic CD4+ T Cells |
Q34658438 | High efficiency of antiviral CD4(+) killer T cells |
Q39392116 | Human CD4+ T cell response to human herpesvirus 6. |
Q64377856 | IL-12p70 and IL-18 gene-modified dendritic cells loaded with tumor antigen-derived peptides or recombinant protein effectively stimulate specific Type-1 CD4+ T-cell responses from normal donors and melanoma patients in vitro |
Q43125547 | IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells |
Q30362489 | Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure? |
Q46335945 | Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva |
Q34059488 | Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses |
Q84953850 | Impairment of CD4+ cytotoxic T cells predicts poor survival and high recurrence rates in patients with hepatocellular carcinoma |
Q35075320 | In vivo identification and characterization of CD4⁺ cytotoxic T cells induced by virulent Brucella abortus infection. |
Q33780032 | Indoxyl sulfate (IS)-mediated immune dysfunction provokes endothelial damage in patients with end-stage renal disease (ESRD). |
Q35106552 | Inflammation enhances IL-2 driven differentiation of cytolytic CD4 T cells |
Q37021884 | Lineage re-commitment of CD4CD8αα intraepithelial lymphocytes in the gut |
Q92800256 | Maintenance of Functional CD57+ Cytolytic CD4+ T Cells in HIV+ Elite Controllers |
Q42576006 | Mapping and restriction of a dominant viral CD4+ T cell core epitope by both MHC class I and MHC class II. |
Q35192417 | Mechanisms of immunity in post-exposure vaccination against Ebola virus infection |
Q41992035 | Multifunctional CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infection |
Q37820489 | New approaches to the development of adenoviral dendritic cell vaccines in melanoma. |
Q36183288 | Off balance: T-cells in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides |
Q42637743 | Phenotypic analysis of human CD4+ T cells specific for immediate-early 63 protein of varicella-zoster virus |
Q39267118 | Preservation of a critical epitope core region is associated with the high degree of flaviviral cross-reactivity exhibited by a dengue-specific CD4+ T cell clone |
Q27490311 | Protective Role of Fas-FasL Signaling in Lethal Infection with Herpes Simplex Virus Type 2 in Mice |
Q39682036 | Quantitative Proteomics of Gut-Derived Th1 and Th1/Th17 Clones Reveal the Presence of CD28+ NKG2D- Th1 Cytotoxic CD4+ T cells |
Q34657661 | Recognition of fresh human tumor by human peripheral blood lymphocytes transduced with a bicistronic retroviral vector encoding a murine anti-p53 TCR. |
Q36143186 | Reduced Plasmodium Parasite Burden Associates with CD38+ CD4+ T Cells Displaying Cytolytic Potential and Impaired IFN-γ Production |
Q26995409 | Revealing the role of CD4(+) T cells in viral immunity |
Q40362733 | Role of CD4+ and CD8+ T cells in clearance of primary pulmonary infection with Coxiella burnetii |
Q47967815 | Social network architecture of human immune cells unveiled by quantitative proteomics |
Q43096910 | Strong ability of Nef-specific CD4+ cytotoxic T cells to suppress human immunodeficiency virus type 1 (HIV-1) replication in HIV-1-infected CD4+ T cells and macrophages |
Q34336323 | T cells in vascular inflammatory diseases |
Q37925862 | T-helper cells as new players in ANCA-associated vasculitides |
Q38725117 | Targeting B-cell malignancies through human B-cell receptor specific CD4+ T cells |
Q26751016 | The Differentiation and Protective Function of Cytolytic CD4 T Cells in Influenza Infection |
Q34587175 | The human T cell response to melanoma antigens |
Q36635015 | Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes |
Q37375614 | Tumor protective activity of CD4+ but not of CD8+ T cells in DNA-vaccinated mice challenged with bcr-abl-transformed cells |
Q37808467 | Tumor vaccines and beyond |
Q39998958 | Varicella zoster virus glycoprotein E-specific CD4+ T cells show evidence of recent activation and effector differentiation, consistent with frequent exposure to replicative cycle antigens in healthy immune donors. |