Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts

scientific article published on 17 December 2009

Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2353/AJPATH.2010.090405
P932PMC publication ID2797901
P698PubMed publication ID20019182
P5875ResearchGate publication ID40696546

P2093author name stringSue Hammond
Paul T Martin
Karen Fernandez
Laura T Martin
Yelda Serinagaoglu
P2860cites workNeural regulation of alpha-dystroglycan biosynthesis and glycosylation in skeletal muscleQ73315875
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Dystrophin-deficient mdx mice display a reduced life span and are susceptible to spontaneous rhabdomyosarcoma.Q51761621
Dystroglycan in development and disease.Q52532615
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Inhibition of dystroglycan binding to laminin disrupts the PI3K/AKT pathway and survival signaling in muscle cells.Q52548027
Loss of suppressor-of-fused function promotes tumorigenesis.Q53334228
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Pathologic classification of rhabdomyosarcomas and correlations with molecular studiesQ34250993
Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcomaQ34334974
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Dystroglycan expression is frequently reduced in human breast and colon cancers and is associated with tumor progression.Q35791328
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Mechanisms of disease: congenital muscular dystrophies-glycosylation takes center stageQ36577280
PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compoundQ36611142
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Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE.Q37160880
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Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.Q37598845
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.Q37598848
Hedgehog-independent overexpression of transforming growth factor-beta1 in rhabdomyosarcoma of Patched1 mutant miceQ38300301
Effects of RAS on the genesis of embryonal rhabdomyosarcoma.Q38301662
Plectin 1f scaffolding at the sarcolemma of dystrophic (mdx) muscle fibers through multiple interactions with beta-dystroglycan.Q39734956
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectembryonal rhabdomyosarcomaQ5370233
P304page(s)416-434
P577publication date2009-12-17
P1433published inThe American Journal of PathologyQ4744259
P1476titleMice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts
P478volume176

Reverse relations

cites work (P2860)
Q46456978A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo
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Q38893243Cavin-1 and Caveolin-1 are both required to support cell proliferation, migration and anchorage-independent cell growth in rhabdomyosarcoma
Q47630972Cytoskeleton and ECM tumor mutant peptides: Increased protease sensitivities and potential consequences for the HLA class I mutant epitope reservoir
Q33886594DNA damage, somatic aneuploidy, and malignant sarcoma susceptibility in muscular dystrophies
Q36167600Deletion of Galgt2 (B4Galnt2) reduces muscle growth in response to acute injury and increases muscle inflammation and pathology in dystrophin-deficient mice
Q39274601Dystroglycan function is a novel determinant of tumor growth and behavior in prostate cancer
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Q64067092Exogenous expression of the glycosyltransferase LARGE1 restores α-dystroglycan matriglycan and laminin binding in rhabdomyosarcoma
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