Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor

scientific article published in March 1999

Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/0264-6021:3380281
P932PMC publication ID1220053
P698PubMed publication ID10024503
P5875ResearchGate publication ID13264063

P2093author name stringKobayashi K
Oka K
Siest G
Chan L
Havekes LM
Hofker MH
van Dijk KW
Jong MC
Dahlmans VE
Van der Boom H
P2860cites workApolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related proteinQ41709963
Synthesis and properties of the very-low-density-lipoprotein receptor and a comparison with the low-density-lipoprotein receptorQ41970201
Reduced very-low-density lipoprotein fractional catabolic rate in apolipoprotein C1-deficient miceQ41995314
Cloning of a cDNA encoding a putative human very low density lipoprotein/apolipoprotein E receptor and assignment of the gene to chromosome 9pter-p23.Q42805194
The metabolism of very low density lipoprotein proteins. I. Preliminary in vitro and in vivo observationsQ43819349
Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor geneQ45877135
Expression of the VLDL receptor in endothelial cellsQ49101801
Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptorQ64382900
Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related proteinQ68819183
The effect of human C apolipoproteins on the in vitro hepatic metabolism of triglyceride emulsions in the ratQ70603231
Both lipolysis and hepatic uptake of VLDL are impaired in transgenic mice coexpressing human apolipoprotein E*3Leiden and human apolipoprotein C1Q71231776
VLDL receptor mediates the uptake of human chylomicron remnants in vitroQ71670700
Modulation of Lipoprotein B Binding to the LDL Receptor by Exogenous Lipids and Apolipoproteins CI, CII, CIII, and EQ71843149
Effect of apolipoprotein C-I peptides on the apolipoprotein E content and receptor-binding properties of beta-migrating very low density lipoproteinsQ72317459
Bone marrow transplantation in apolipoprotein E-deficient mice. Effect of ApoE gene dosage on serum lipid concentrations, (beta)VLDL catabolism, and atherosclerosisQ73965942
Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptorQ74100225
Protein measurement with the Folin phenol reagentQ20900776
Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificityQ24293268
Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liverQ24300330
The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptorQ24319741
Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathwayQ24323234
Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnantsQ24564846
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene deliveryQ29615235
Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptorQ33982023
Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptorsQ34263181
Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal miceQ36201407
Combined hyperlipidemia in transgenic mice overexpressing human apolipoprotein ClQ37358494
In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathwayQ37361432
Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein C1.Q37376984
Lipoprotein lipase stimulates the binding and uptake of moderately oxidized low-density lipoprotein by J774 macrophagesQ41222701
Enhancement of the binding of triglyceride-rich lipoproteins to the very low density lipoprotein receptor by apolipoprotein E and lipoprotein lipaseQ41333469
Very low density lipoprotein receptor from mammary gland and mammary epithelial cell lines binds and mediates endocytosis of M(r) 40,000 receptor associated proteinQ41429335
Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene.Q41493690
Lipoprotein lipase (EC 3.1.1.34) targeting of lipoproteins to receptorsQ41571853
P407language of work or nameEnglishQ1860
P921main subjectlipoproteinQ28350
AdenoviridaeQ193447
hyperlipidemiaQ1079120
P304page(s)281-287
P577publication date1999-03-01
P1433published inBiochemical JournalQ864221
P1476titleReversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor
P478volume338 ( Pt 2)

Reverse relations

cites work (P2860)
Q37222426ApoE and ApoC-I polymorphisms: association of genotype with cardiovascular disease phenotype in African Americans
Q36294705Apolipoprotein C-I Levels Are Associated with the Urinary Protein/Urinary Creatinine Ratio in Pediatric Idiopathic Steroid-Sensitive Nephrotic Syndrome: A Case Control Study
Q92861943Apolipoprotein C1 (APOC1) promotes tumor progression via MAPK signaling pathways in colorectal cancer
Q37299858Apolipoprotein CI is a physiological regulator of cholesteryl ester transfer protein activity in human plasma but not in rabbit plasma.
Q41825540Apolipoprotein CI overexpression is not a relevant strategy to block cholesteryl ester transfer protein (CETP) activity in CETP transgenic mice
Q48315712Apolipoproteins E and C1 and brain morphology in memory impaired elders.
Q48217772Cloning and spatiotemporal expression of Xenopus laevis Apolipoprotein CI.
Q33926011Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice.
Q33519546Identifying blood biomarkers and physiological processes that distinguish humans with superior performance under psychological stress
Q73668740Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphism
Q36930204WAT apoC-I secretion: role in delayed chylomicron clearance in vivo and ex vivo in WAT in obese subjects

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