Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein

scientific article published in August 2000

Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1099/0022-1317-81-8-1913
P698PubMed publication ID10900028
P5875ResearchGate publication ID12419299

P2093author name stringMcLauchlan J
Hope RG
P433issuePt 8
P407language of work or nameEnglishQ1860
P921main subjecthepatitis CQ154869
Hepatitis C virusQ708693
P304page(s)1913-1925
P577publication date2000-08-01
P1433published inJournal of General VirologyQ6295245
P1476titleSequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein
P478volume81

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cites work (P2860)
Q34120119A disulfide-bonded dimer of the core protein of hepatitis C virus is important for virus-like particle production
Q35619799Access of viral proteins to mitochondria via mitochondria-associated membranes
Q27481484Alanine Scanning of the Hepatitis C Virus Core Protein Reveals Numerous Residues Essential for Production of Infectious Virus
Q33321721Altered expression patterns of lipid metabolism genes in an animal model of HCV core-related, nonobese, modest hepatic steatosis
Q27473200Analysis of hepatitis C virus RNA dimerization and core-RNA interactions
Q39068693Apolipoprotein E codetermines tissue tropism of hepatitis C virus and is crucial for viral cell-to-cell transmission by contributing to a postenvelopment step of assembly
Q27486525Binding of liver derived, low density hepatitis C virus to human hepatoma cells
Q45697410Biophysical characterization of hepatitis C virus core protein: implications for interactions within the virus and host
Q40822259Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell
Q39915846Cellular vimentin content regulates the protein level of hepatitis C virus core protein and the hepatitis C virus production in cultured cells
Q27478429Chronic hepatitis associated with GB virus B persistence in a tamarin after intrahepatic inoculation of synthetic viral RNA
Q30409246Conserved glycine 33 residue in flexible domain I of hepatitis C virus core protein is critical for virus infectivity
Q27485249Core protein cleavage by signal peptide peptidase is required for hepatitis C virus-like particle assembly
Q27485242Core protein domains involved in hepatitis C virus-like particle assembly and budding at the endoplasmic reticulum membrane
Q27477993Critical role of PA28 in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis
Q47925533Critical roles for α/β hydrolase domain 5 (ABHD5)/comparative gene identification-58 (CGI-58) at the lipid droplet interface and beyond
Q37201846Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems
Q27489906Dengue Virus Capsid Protein Usurps Lipid Droplets for Viral Particle Formation
Q38868883Dengue Virus Uses a Non-Canonical Function of the Host GBF1-Arf-COPI System for Capsid Protein Accumulation on Lipid Droplets
Q35826556Dengue virus capsid protein binding to hepatic lipid droplets (LD) is potassium ion dependent and is mediated by LD surface proteins
Q43037437Effect of cAMP-dependent protein kinase A (PKA) on HCV nucleocapsid assembly and degradation
Q35709709Emerging role of lipid droplets in host/pathogen interactions.
Q38848095Entangled in a membranous web: ER and lipid droplet reorganization during hepatitis C virus infection
Q40413349Evidence for an association between heat shock protein 70 and the respiratory syncytial virus polymerase complex within lipid-raft membranes during virus infection
Q37986051Exploitation of lipid components by viral and host proteins for hepatitis C virus infection
Q24537657Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex
Q44445920Fixation Methods for the Study of Lipid Droplets by Immunofluorescence Microscopy
Q38772047Genotype 3 Infection: The Last Stand of Hepatitis C Virus
Q41743928Hallmarks of hepatitis C virus in equine hepacivirus
Q40141993Hepatitis C Virus NS5A Targets Nucleosome Assembly Protein NAP1L1 To Control the Innate Cellular Response
Q40213539Hepatitis C virus core protein associates with detergent-resistant membranes distinct from classical plasma membrane rafts
Q33313498Hepatitis C virus core protein binding to lipid membranes: the role of domains 1 and 2.
Q27470776Hepatitis C virus core protein is a dimeric alpha-helical protein exhibiting membrane protein features
Q43047222Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins
Q37034456Hepatitis C virus core protein, lipid droplets and steatosis
Q35212817Hepatitis C virus e2 protein ectodomain is essential for assembly of infectious virions
Q45398101Hepatitis C virus living off the fat of the land
Q36580492Hepatitis C virus utilizes lipid droplet for production of infectious virus
Q36060022Hepatitis C virus-induced hepatocellular steatosis.
Q34560646How does hepatitis C virus enter cells?
Q34034833Hydrophobic and basic domains target proteins to lipid droplets
Q42825907Hydrophobic sequences target and anchor perilipin A to lipid droplets
Q33258584Identification and characterization of associated with lipid droplet protein 1: A novel membrane-associated protein that resides on hepatic lipid droplets
Q27469606Identification of Residues in the Hepatitis C Virus Core Protein That Are Critical for Capsid Assembly in a Cell-Free System
Q34062275Identification of a functional, CRM-1-dependent nuclear export signal in hepatitis C virus core protein
Q34761048Identification of diverse lipid droplet targeting motifs in the PNPLA family of triglyceride lipases
Q39090584Immune modulation by the hepatitis C virus core protein
Q37230981Impact of host and virus genome variability on HCV replication and response to interferon
Q34999693Inhibition of HCV replication by oxysterol-binding protein-related protein 4 (ORP4) through interaction with HCV NS5B and alteration of lipid droplet formation
Q27488371Initiation of Hepatitis C Virus Infection Requires the Dynamic Microtubule Network: ROLE OF THE VIRAL NUCLEOCAPSID PROTEIN
Q99616359Inositol requiring enzyme 1α promotes Zika virus infection through regulating stearoyl-CoA desaturase 1 mediated lipid metabolism
Q34160337Interaction of hepatitis C virus proteins with host cell membranes and lipids
Q37788976Interaction of the hepatitis C virus (HCV) core with cellular genes in the development of HCV-induced steatosis.
Q27488209Internal Initiation Stimulates Production of p8 Minicore, a Member of a Newly Discovered Family of Hepatitis C Virus Core Protein Isoforms
Q40214972Intracellular imaging of HCV RNA and cellular lipids by using simultaneous two-photon fluorescence and coherent anti-Stokes Raman scattering microscopies
Q34193354Intramembrane proteolysis and endoplasmic reticulum retention of hepatitis C virus core protein
Q24534284Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets
Q33922423Kinetic analysis of the nucleic acid chaperone activity of the hepatitis C virus core protein
Q42244227Lipid droplet binding of hepatitis C virus core protein genotype 3.
Q34343165Lipid droplets: proteins floating on a pool of fat.
Q28210379Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein
Q39990457Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production
Q35669529Mechanisms of hepatitis C virus infection
Q31120481Membrane binding properties and terminal residues of the mature hepatitis C virus capsid protein in insect cells
Q57015945Methods for Lipid Droplet Biophysical Characterization in Infections
Q24329074Modulation of the type I interferon pathways by culture-adaptive hepatitis C virus core mutants
Q33985223Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus.
Q37743200Molecular determinants for subcellular localization of hepatitis C virus core protein
Q39969739Morphological changes in intracellular lipid droplets induced by different hepatitis C virus genotype core sequences and relationship with steatosis
Q28594324Murine diacylglycerol acyltransferase-2 (DGAT2) can catalyze triacylglycerol synthesis and promote lipid droplet formation independent of its localization to the endoplasmic reticulum
Q29620681Novel insights into hepatitis C virus replication and persistence
Q27477612Oligomerization of Hepatitis C Virus Core Protein Is Crucial for Interaction with the Cytoplasmic Domain of E1 Envelope Protein
Q28075646Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis
Q27490522Palmitoylation of Hepatitis C Virus Core Protein Is Important for Virion Production
Q27472869Persistent and transient replication of full-length hepatitis C virus genomes in cell culture
Q47550180Polymorphisms in the hepatitis C virus core and its association with development of hepatocellular carcinoma
Q27481398Preferential association of Hepatitis C virus with apolipoprotein B48-containing lipoproteins
Q27473029Proapoptotic and pronecrosis effect of different truncated hepatitis C virus core proteins
Q35826594Production of infectious chimeric hepatitis C virus genotype 2b harboring minimal regions of JFH-1.
Q33637110Properties and Functions of the Dengue Virus Capsid Protein
Q24322067Proteasome activator PA28gamma-dependent nuclear retention and degradation of hepatitis C virus core protein
Q27485379RNA chaperoning and intrinsic disorder in the core proteins of Flaviviridae
Q36146807Rapid Increase in Serum Low-Density Lipoprotein Cholesterol Concentration during Hepatitis C Interferon-Free Treatment
Q90787682Regulation of PKCβ levels and autophagy by PML is essential for high-glucose-dependent mesenchymal stem cell adipogenesis
Q37558730Relationship between humoral response against hepatitis C virus and disease overcome.
Q33910745Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein
Q28213796Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis
Q37621569Role of lipid metabolism in hepatitis C virus assembly and entry
Q36321772Role of the hydrophobic domain in targeting caveolin-1 to lipid droplets
Q43001715Signal peptide peptidase cleavage of GB virus B core protein is required for productive infection in vivo
Q42036653Signal peptide peptidase-catalyzed cleavage of hepatitis C virus core protein is dispensable for virus budding but destabilizes the viral capsid
Q33878202Small molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action
Q27486390Specific Polymorphisms in Hepatitis C Virus Genotype 3 Core Protein Associated with Intracellular Lipid Accumulation
Q27679127Structural Analysis of Hepatitis C Virus Core-E1 Signal Peptide and Requirements for Cleavage of the Genotype 3a Signal Sequence by Signal Peptide Peptidase
Q57064243Structural Proteins of HCV and Biological Functions
Q56762917Structural biology of hepatitis C virus
Q35105684Structural biology of hepatitis C virus
Q43000172Structural determinants that target the hepatitis C virus core protein to lipid droplets.
Q27473047Subcellular localization of hepatitis C virus structural proteins in a cell culture system that efficiently replicates the virus
Q40688252Suppression of hepatitis B virus enhancer 1 and 2 by hepatitis C virus core protein
Q40535841Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif
Q64086690The Immunogenicity in Mice of HCV Core Delivered as DNA Is Modulated by Its Capacity to Induce Oxidative Stress and Oxidative Stress Response
Q35764429The Replacement of 10 Non-Conserved Residues in the Core Protein of JFH-1 Hepatitis C Virus Improves Its Assembly and Secretion
Q40768996The domains required to direct core proteins of hepatitis C virus and GB virus-B to lipid droplets share common features with plant oleosin proteins.
Q27485480The genotype 3-specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model
Q34518202The hepatitis C virus core protein can modulate RNA-dependent RNA synthesis by the 2a polymerase
Q24314941The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1
Q42998138The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication
Q28749823The life of lipid droplets
Q43170500The polyomavirus BK agnoprotein co-localizes with lipid droplets.
Q40078310The potential of signal peptide peptidase as a therapeutic target for hepatitis C.
Q33962697The wild-type hepatitis C virus core inhibits initiation of antigen-specific T- and B-cell immune responses in BALB/c mice
Q34098656Topological and evolutional relationships between HCV core protein and hepatic lipid vesicles: studies in vitro and in conditionally transgenic mice
Q33400538Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus
Q47550796Ultrastructural Localization and Molecular Associations of HCV Capsid Protein in Jurkat T Cells.
Q39710437Ultrastructural and quantitative analysis of the lipid droplet clustering induced by hepatitis C virus core protein
Q90053464Very-long-chain fatty acid metabolic capacity of 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) promotes replication of hepatitis C virus and related flaviviruses
Q35544097Virus-host cell interactions during hepatitis C virus RNA replication: impact of polyprotein expression on the cellular transcriptome and cell cycle association with viral RNA synthesis
Q33889967Visualization and analysis of hepatitis C virus structural proteins at lipid droplets by super-resolution microscopy.
Q27485448Visualization of Double-Stranded RNA in Cells Supporting Hepatitis C Virus RNA Replication

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