Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-X(L) and Mcl-1 expressing human cholangiocarcinoma cells

scientific article published on October 2002

Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-X(L) and Mcl-1 expressing human cholangiocarcinoma cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/GUT.51.4.556
P932PMC publication ID1773378
P698PubMed publication ID12235080
P5875ResearchGate publication ID245826589

P2093author name stringD A Fennell
F E Cotter
M Corbo
B R Davidson
A C Okaro
P2860cites workBad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell deathQ24311298
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue KineticsQ24564912
5-Aminolaevulinic acid-induced protoporphyrin IX accumulation in tissues: pharmacokinetics after oral or intravenous administrationQ32018881
Bcl-2 antisense therapy in multiple myeloma.Q33587931
Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxideQ34478428
Mitochondrial permeability transition is a central coordinating event of apoptosisQ36367290
Photodynamic therapy using intravenous delta-aminolaevulinic acid-induced protoporphyrin IX sensitisation in experimental hepatic tumours in ratsQ36834046
The role of antiapoptotic Bcl-2 family members in endothelial apoptosis elucidated with antisense oligonucleotidesQ38326195
p53 but not bcl-2 is expressed by most cholangiocarcinomas: a study of 28 casesQ38468205
Surgical palliation of small bowel obstruction due to metastatic carcinomaQ39568458
The expression of antiapoptotic proteins Bcl-2, Bcl-X(L), and Mcl-1 in benign, dysplastic, and malignant biliary epitheliumQ40765637
Apoptosis: a product of programmed and unprogrammed cell deathQ40828308
Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell lineQ41085962
The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transitionQ41150411
Establishment of a new extrahepatic bile duct carcinoma cell line, TFK-1.Q41298622
Apoptosis and the dilemma of cancer chemotherapy.Q41372240
Role of the mitochondrial permeability transition pore in apoptosisQ41488918
Avoidance of apoptosis as a mechanism of drug resistanceQ41626423
Mitochondrial permeability transition in apoptosis and necrosisQ41745048
Photodynamic tumor therapy: mitochondrial benzodiazepine receptors as a therapeutic target.Q41919293
Overexpression of Bcl-2 or Bcl-xL inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells.Q42553523
Immunohistochemical detection of bcl-2 protein in normal and pathological human liver.Q42754664
Leucovorin, 5-fluorouracil, and gemcitabine: a phase I studyQ44865642
The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death.Q52528138
Photodynamic therapy of nonresectable cholangiocarcinoma.Q52996561
BCL-2 antisense therapy in patients with non-Hodgkin lymphomaQ61868294
bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repairQ64389791
Medical management of intestinal obstruction in patients with advanced malignant disease. A clinical and pathological studyQ68946023
Surgical management of intestinal obstruction in ovarian cancer. I. Clinical features, postoperative complications, and survivalQ68980832
Phase II evaluation of cisplatin in advanced hepatocellular carcinoma and cholangiocarcinoma: a Southeastern Cancer Study Group TrialQ70126825
Bcl-xL overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cellsQ73148803
[Palliative therapy of gastrointestinal obstruction]Q73359511
Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosisQ73555140
Synthesis and biology of a 7-nitro-2,1,3-benzoxadiazol-4-yl derivative of 2-phenylindole-3-acetamide: a fluorescent probe for the peripheral-type benzodiazepine receptorQ73589795
Phase II trial of docetaxel for cholangiocarcinomaQ74455186
A phase II trial of 5-fluorouracil, leucovorin, and carboplatin in patients with unresectable biliary tree carcinomaQ74681551
Mitochondrial control of apoptosis: the role of cytochrome cQ77136010
Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition poreQ77874093
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcholangiocarcinomaQ124292
P304page(s)556-561
P577publication date2002-10-01
P1433published inGutQ5621669
P1476titlePk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-X(L) and Mcl-1 expressing human cholangiocarcinoma cells
P478volume51

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cites work (P2860)
Q33841673Anti-apoptotic effects of osteopontin through the up-regulation of Mcl-1 in gastrointestinal stromal tumors
Q43142193Antiproliferative effect of peripheral benzodiazepine receptor antagonist PK11195 in rat mammary tumor cells
Q35172032Apoptosis and the liver: relation to autoimmunity and related conditions
Q38597008Cholangiocarcinoma: from molecular biology to treatment
Q35789268Defective core-apoptosis signalling in diffuse malignant pleural mesothelioma: opportunities for effective drug development
Q51225032High expression of apoptosis-inducing factor, mitochondrion-associated 3 (AIFM3) in human cholangiocarcinoma.
Q39782298Modulation of intracellular Ca2+ signalling in HeLa cells by the apoptotic cell death enhancer PK11195.
Q35847659PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism
Q39171620Sex-dependent mental illnesses and mitochondria
Q38938735TSPO ligand residence time influences human glioblastoma multiforme cell death/life balance.
Q34115304Targeting mitochondria for cancer therapy
Q37862534Targeting the mitochondrial permeability transition: cardiac ischemia-reperfusion versus carcinogenesis
Q38221277The translocator protein as a potential molecular target for improved treatment efficacy in photodynamic therapy.

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