Defective core-apoptosis signalling in diffuse malignant pleural mesothelioma: opportunities for effective drug development

scientific article published on June 2004

Defective core-apoptosis signalling in diffuse malignant pleural mesothelioma: opportunities for effective drug development is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S1470-2045(04)01492-5
P698PubMed publication ID15172356

P2093author name stringDean A Fennell
Robin M Rudd
P2860cites workAntioxidant defense mechanisms of human mesothelioma and lung adenocarcinoma cellsQ42486069
Growth factor responses and protooncogene expression of murine mesothelial cell lines derived from asbestos-induced mesotheliomasQ42816861
Pk11195, a mitochondrial benzodiazepine receptor antagonist, reduces apoptosis threshold in Bcl-X(L) and Mcl-1 expressing human cholangiocarcinoma cellsQ43006133
Tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy cooperate to induce apoptosis in mesothelioma cell linesQ43687803
Significant augmentation of pro-apoptotic gene therapy by pharmacologic bcl-xl down-regulation in mesotheliomaQ43747147
Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesotheliomaQ43802258
The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondriaQ43884355
Phosphatase and tensin analog gene overexpression engenders cellular death in human malignant mesothelioma cells via inhibition of AKT phosphorylationQ43939949
AKT and the phosphatidylinositol 3-kinase/AKT pathway: important molecular targets for lung cancer prevention and treatmentQ44319490
Simian virus-40 large-T antigen binds p53 in human mesotheliomas.Q45761189
Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivoQ48548442
A high-throughput screen for identification of molecular mimics of Smac/DIABLO utilizing a fluorescence polarization assay.Q52101478
Apoptosis in developmentQ59060825
Immunohistochemical distribution patterns of epidermal growth factor receptor in malignant mesothelioma and non-neoplastic mesotheliumQ68023181
Expression of growth factor and growth factor receptor RNA in rat pleural mesothelial cells in cultureQ68093801
Phase II study of vinorelbine in patients with malignant pleural mesotheliomaQ73250833
Increased expression of epidermal growth factor receptor in rat pleural mesothelial cells correlates with carcinogenicity of mineral fibresQ73336080
Alterations of the p16(INK4) locus in human malignant mesothelial tumorsQ74461537
Overexpression of peroxiredoxins I, II, III, V, and VI in malignant mesotheliomaQ77667294
Conformation of the Bax C-terminus regulates subcellular location and cell deathQ24534099
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue KineticsQ24564912
The European mesothelioma epidemicQ24650064
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machineryQ27860586
Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesotheliomaQ28206578
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)Q28297419
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and deathQ28363890
Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen speciesQ28365278
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinaseQ28366319
Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosisQ28369114
Two CD95 (APO-1/Fas) signaling pathwaysQ29619631
Antisense therapy for malignant mesothelioma with oligonucleotides targeting the bcl-xl gene productQ33183808
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosomeQ34154044
Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesotheliomaQ34214330
Apoptosis: a link between cancer genetics and chemotherapyQ34520432
Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membraneQ34647032
Targeting Bcl-2 and Bcl-X with nonpeptidic small-molecule antagonistsQ35581826
Malignant pleural mesothelioma and epidermal growth factor receptor (EGF-R). Relationship of EGF-R with histology and survival using fixed paraffin embedded tissue and the F4, monoclonal antibodyQ35982617
The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T-antigen in human mesotheliomasQ38474132
Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL-R1 and TRAIL-R2Q40623393
Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptorQ40732059
The permeability transition pore signals apoptosis by directing Bax translocation and multimerization.Q40741871
Induction of apoptosis in malignant pleural mesothelioma cells by activation of the Fas (Apo-1/CD95) death-signal pathwayQ40752717
Redox cycling by motexafin gadolinium enhances cellular response to ionizing radiation by forming reactive oxygen speciesQ40769371
Manganese superoxide dismutase in healthy human pleural mesothelium and in malignant pleural mesotheliomaQ41047702
Manganese superoxide dismutase in human pleural mesothelioma cell linesQ41246097
Induction of apoptosis and chemosensitization of mesothelioma cells by Bcl-2 and Bcl-xL antisense treatment.Q42442790
P433issue6
P921main subjectapoptotic processQ14599311
malignant pleural mesotheliomaQ18557602
P304page(s)354-362
P577publication date2004-06-01
P1433published inLancet Oncology CommissionQ13747613
P1476titleDefective core-apoptosis signalling in diffuse malignant pleural mesothelioma: opportunities for effective drug development
P478volume5

Reverse relations

cites work (P2860)
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