Update on the molecular biology of malignant mesothelioma

scientific article published on April 2007

Update on the molecular biology of malignant mesothelioma is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/CNCR.22552
P698PubMed publication ID17348013
P5875ResearchGate publication ID6458956

P2093author name stringAmie Y Lee
Biao He
David M Jablons
Dan J Raz
P2860cites workThe European mesothelioma epidemicQ24650064
Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamstersQ24676844
Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regressionQ47814346
Global gene expression profiling of pleural mesotheliomas: overexpression of aurora kinases and P16/CDKN2A deletion as prognostic factors and critical evaluation of microarray-based prognostic prediction.Q53632285
Cadherins, catenins and APC in pleural malignant mesotheliomaQ54516140
EGFR overexpression in malignant pleural mesotheliomaQ61698043
The use of CDKN2A deletion as a diagnostic marker for malignant mesothelioma in body cavity effusionsQ63547911
Immunoreactivity for bcl-2 protein in malignant mesothelioma and non-neoplastic mesotheliumQ72117372
Increased expression of epidermal growth factor receptor in rat pleural mesothelial cells correlates with carcinogenicity of mineral fibresQ73336080
The gene for the cyclin-dependent-kinase-4 inhibitor, CDKN2A, is preferentially deleted in malignant mesotheliomaQ74185593
Alterations of the p16(INK4) locus in human malignant mesothelial tumorsQ74461537
Expression of vascular endothelial growth factor in diffuse malignant pleural mesotheliomaQ78081432
Angiogenic cytokines in mesothelioma: a study of VEGF, FGF-1 and -2, and TGF beta expressionQ78140641
EGFR expression: associations with outcome and clinicopathological variables in malignant pleural mesotheliomaQ79268942
The expression pattern of beta-catenin in mesothelial proliferative lesions and its diagnostic utilitiesQ81382355
Prognostic significance of vascular endothelial growth factor, tumor necrosis, and mitotic activity index in malignant pleural mesotheliomaQ81519769
P16 loss and mitotic activity predict poor survival in patients with peritoneal malignant mesotheliomaQ81707933
The INK4a/ARF network in tumour suppressionQ28190064
Tumor suppression by Ink4a-Arf: progress and puzzlesQ28207959
Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loopsQ28210619
Expression of the secreted frizzled-related protein gene family is downregulated in human mesotheliomaQ28268844
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesisQ29547178
Antisense therapy for malignant mesothelioma with oligonucleotides targeting the bcl-xl gene productQ33183808
The use of immunohistochemistry in distinguishing reactive from neoplastic mesothelium. A novel use for desmin and comparative evaluation with epithelial membrane antigen, p53, platelet-derived growth factor-receptor, P-glycoprotein and Bcl-2.Q33389811
Asbestos, chromosomal deletions, and tumor suppressor gene alterations in human malignant mesotheliomaQ33680576
SV40 and human tumours: myth, association or causality?Q34161997
Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesotheliomaQ34214330
Review of epidermal growth factor receptor biologyQ34320636
Wnt2 as a new therapeutic target in malignant pleural mesotheliomaQ34419678
Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesotheliomaQ34499542
A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cellsQ34787867
Asbestos and the pleura: a reviewQ35684938
Experimental therapy of malignant mesothelioma: new perspectives from anti-angiogenic treatmentsQ35780958
Defective core-apoptosis signalling in diffuse malignant pleural mesothelioma: opportunities for effective drug developmentQ35789268
Moving beyond chemotherapy: novel cytostatic agents for malignant mesotheliomaQ35839893
Malignant pleural mesothelioma and epidermal growth factor receptor (EGF-R). Relationship of EGF-R with histology and survival using fixed paraffin embedded tissue and the F4, monoclonal antibodyQ35982617
Persistent induction of c-fos and c-jun expression by asbestosQ36236354
VEGF and VEGF type C play an important role in angiogenesis and lymphangiogenesis in human malignant mesothelioma tumours.Q36641154
Expression of bcl-2 family members in malignant pleural mesotheliomaQ38437441
The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T-antigen in human mesotheliomasQ38474132
Immunohistochemical analysis of the p16INK4 cyclin-dependent kinase inhibitor in malignant mesotheliomaQ38479413
A novel SV40 TAg transgenic model of asbestos-induced mesothelioma: malignant transformation is dose dependentQ40208072
Involvement of IL-10 and Bcl-2 in resistance against an asbestos-induced apoptosis of T cellsQ40253864
Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomasQ40287001
Inactivation of p16INK4a expression in malignant mesothelioma by methylationQ40694393
Enhanced expression of vascular endothelial growth factor (VEGF) plays a critical role in the tumor progression potential induced by simian virus 40 large T antigenQ40735845
The presence of simian-virus 40 sequences in mesothelioma and mesothelial cells is associated with high levels of vascular endothelial growth factorQ40755750
Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cellsQ41731114
Induction of apoptosis and chemosensitization of mesothelioma cells by Bcl-2 and Bcl-xL antisense treatment.Q42442790
Vascular endothelial growth factor is an autocrine growth factor in human malignant mesotheliomaQ43558001
Significant augmentation of pro-apoptotic gene therapy by pharmacologic bcl-xl down-regulation in mesotheliomaQ43747147
Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesotheliomaQ43802258
Simian virus-40 large-T antigen binds p53 in human mesotheliomas.Q45761189
Gene therapy of established mesothelioma xenografts with recombinant p16INK4a adenovirusQ45873541
Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell linesQ45873629
Gefitinib in patients with malignant mesothelioma: a phase II study by the Cancer and Leukemia Group B.Q46402560
The selective epidermal growth factor receptor tyrosine kinase inhibitor PD153035 suppresses expression of prometastasis phenotypes in malignant pleural mesothelioma cells in vitroQ46469316
Common EGFR mutations conferring sensitivity to gefitinib in lung adenocarcinoma are not prevalent in human malignant mesothelioma.Q46625222
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmolecular biologyQ7202
P304page(s)1454-1461
P577publication date2007-04-01
P1433published inCancerQ326041
P1476titleUpdate on the molecular biology of malignant mesothelioma
P478volume109

Reverse relations

cites work (P2860)
Q397070423-O-Methylfunicone, a metabolite produced by Penicillium pinophilum, modulates ERK1/2 activity, affecting cell motility of human mesothelioma cells.
Q474256204EGI-1 represses cap-dependent translation and regulates genome-wide translation in malignant pleural mesothelioma.
Q35855798A clinical protocol to inhibit the HGF/c-Met pathway for malignant mesothelioma with an intrapleural injection of adenoviruses expressing the NK4 gene.
Q41846143A potential therapeutic strategy for malignant mesothelioma with gene medicine
Q54409505A3 Receptors Are Overexpressed in Pleura from Patients with Mesothelioma and Reduce Cell Growth via Akt/Nuclear Factor-κB Pathway
Q37692445Abrogating G₂/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma
Q37287506Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma.
Q60928995Biodistribution and Tumor Uptake of Ga-Nimotuzumab in a Malignant Pleural Mesothelioma Xenograft
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Q36074154Combination of a third generation bisphosphonate and replication-competent adenoviruses augments the cytotoxicity on mesothelioma
Q59033566Comparative proteomic analysis of malignant pleural mesothelioma evidences an altered expression of nuclear lamin and filament-related proteins
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Q37449036Future developments in the management of malignant pleural mesothelioma
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Q33862523HER1-targeted 86Y-panitumumab possesses superior targeting characteristics than 86Y-cetuximab for PET imaging of human malignant mesothelioma tumors xenografts
Q55311618Heat shock protein 90 inhibitors augment endogenous wild-type p53 expression but down-regulate the adenovirally-induced expression by inhibiting a proteasome activity.
Q34974037Interferon-β produces synergistic combinatory anti-tumor effects with cisplatin or pemetrexed on mesothelioma cells
Q42073845Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients
Q33691348Lovastatin Inhibits VEGFR and AKT Activation: Synergistic Cytotoxicity in Combination with VEGFR Inhibitors
Q31019143MDM2 and HIF1alpha expression levels in different histologic subtypes of malignant pleural mesothelioma: correlation with pathological and clinical data
Q34080881Malignant pleural and peritoneal mesothelioma consequential to brief indirect asbestos exposure
Q36361245Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways
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Q39501588New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization
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Q34589641Peritoneal mesothelioma in a woman who has survived for seven years: a case report
Q39841354Placenta growth factor is a survival factor for human malignant mesothelioma cells
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Q92591513Screening of Pleural Mesothelioma Cell Lines for Kinase Activity May Identify New Mechanisms of Therapy Resistance in Patients Receiving Platin-Based Chemotherapy
Q37290519Screening of Pleural Mesotheliomas for DNA-damage Repair Players by Digital Gene Expression Analysis Can Enhance Clinical Management of Patients Receiving Platin-Based Chemotherapy.
Q33874196The investigation of effects of quercetin and its combination with Cisplatin on malignant mesothelioma cells in vitro
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Q39431961β-catenin expression in benign and malignant pleural disorders.

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