The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses

scientific article published on 3 January 2013

The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.IMMUNI.2012.09.021
P932PMC publication ID3556779
P698PubMed publication ID23290522
P5875ResearchGate publication ID234069143

P50authorNatascha Hermann-KleiterQ120598795
P2093author name stringGottfried Baier
Thomas Gruber
Michael Leitges
Katarzyna Wachowicz
Antonella Viola
Cristiana Soldani
Christa Pfeifhofer-Obermair
Friedrich Fresser
Reinhard Hinterleitner
Sandra Kaminski
Marlies Meisel
P2860cites workIL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor bindingQ24291729
Fate mapping of IL-17-producing T cells in inflammatory responsesQ24621244
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5Q24635387
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosisQ24681662
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
IL-17 and Th17 CellsQ27860566
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
Mechanisms of TGF-beta signaling from cell membrane to the nucleusQ27860785
Tob is a negative regulator of activation that is expressed in anergic and quiescent T cellsQ28203889
Transforming growth factor-beta induces development of the T(H)17 lineageQ28237370
Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK populationQ47449482
PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivoQ48030302
Genetic proof for the transient nature of the Th17 phenotype.Q51029281
Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease.Q53597450
Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells.Q54363211
Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development.Q54424331
A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responsesQ60035686
Differentiation of vascular myofibroblasts induced by transforming growth factor-beta1 requires the involvement of protein kinase CalphaQ73927427
Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitisQ79264742
Suppression of immune induction of collagen-induced arthritis in IL-17-deficient miceQ79317500
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitisQ79755041
Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitisQ82136598
Defective IgG2a/2b class switching in PKC alpha-/- miceQ83276363
Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-β is mediated by suppression of eomesoderminQ84159819
STAT3 regulates cytokine-mediated generation of inflammatory helper T cellsQ28286840
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cellsQ28296956
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gammaQ28506783
IL-23 drives a pathogenic T cell population that induces autoimmune inflammationQ29547525
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainQ29614225
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitisQ29620481
Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cellsQ29622847
PRKCA and multiple sclerosis: association in two independent populationsQ33238942
Expression profiling of genes regulated by TGF-beta: differential regulation in normal and tumour cells.Q33281716
Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependentQ33730117
The PDE1A-PKCalpha signaling pathway is involved in the upregulation of alpha-smooth muscle actin by TGF-beta1 in adventitial fibroblastsQ33792164
Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosisQ33862720
TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2.Q33931833
Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypesQ34066077
PKCα-induced drug resistance in pancreatic cancer cells is associated with transforming growth factor-β1Q34076809
T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitisQ34107156
SMAD2 is essential for TGF beta-mediated Th17 cell generation.Q34121444
Non-Smad TGF-beta signalsQ34443708
Protein kinase C(theta) in T cell activationQ34542294
Plasticity of CD4+ T cell lineage differentiation.Q34982725
The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.Q35049530
Conserved intergenic elements and DNA methylation cooperate to regulate transcription at the il17 locusQ36127166
Regulation of inflammatory responses by IL-17FQ36639980
Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiationQ36948735
Foxp3+ regulatory T cells in the control of experimental CNS autoimmune diseaseQ37031066
IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in miceQ37036086
The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunityQ37087730
PKC inhibitors: potential in T cell-dependent immune diseasesQ37386173
Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 profilesQ37386461
Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiationQ37467518
GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complexQ37697197
Late developmental plasticity in the T helper 17 lineageQ39265291
Mechanism of TGFbeta receptor inhibition by FKBP12Q41101968
The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation.Q41840327
Transforming growth factor beta and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding siteQ41854472
Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis.Q42944465
Smad3 is essential for TGF-beta 1 to suppress IL-2 production and TCR-induced proliferation, but not IL-2-induced proliferationQ44807473
Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.Q44894318
Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2.Q46499482
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)41-52
P577publication date2013-01-03
P1433published inImmunityQ6005457
P1476titleThe kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses
P478volume38

Reverse relations

cites work (P2860)
Q89531363Genome-Wide Association Study of Cryptosporidiosis in Infants Implicates PRKCA
Q33289411LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis
Q28975627MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis
Q35898494Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation
Q38268442Protein kinase C in cellular transformation: a valid target for therapy?
Q36377731Protein kinase C theta is dispensable for suppression mediated by CD25+CD4+ regulatory T cells.
Q27334727Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells
Q38268433Protein kinase C: a regulator of cytoskeleton remodelling and T-cell migration.
Q54309549Protein kinase Cθ: the pleiotropic T-cell signalling intermediate.
Q50855811SLA-PGN-primed dendritic cell-based vaccination induces Th17-mediated protective immunity against experimental visceral leishmaniasis: a crucial role of PKCβ.

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