Adiponectin receptor-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: an in vivo and in vitro study

scientific article published on 6 August 2015

Adiponectin receptor-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: an in vivo and in vitro study is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1003246738
P356DOI10.1038/CDDIS.2015.220
P932PMC publication ID4558511
P698PubMed publication ID26247729
P5875ResearchGate publication ID280910895

P50authorJong Eun LeeQ38323530
P2093author name stringE Kim
J Song
S M Kang
C-H Kim
H-T Song
P2860cites workInsulin stimulates postsynaptic density-95 protein translation via the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathwayQ45310588
Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering.Q45756113
Mechanisms involved in cholesterol-induced neuronal insulin resistance.Q45970926
p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.Q46022806
Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastomaQ46158804
Adiponectin receptor 1 enhances fatty acid metabolism and cell survival in palmitate-treated HepG2 cells through the PI3 K/AKT pathwayQ46184080
Globular adiponectin inhibits ethanol-induced apoptosis in HepG2 cells through heme oxygenase-1 inductionQ46309609
Diabetes and cognitive decline: are steroids the missing link?Q46658344
Prominently decreased hippocampal neurogenesis in a spontaneous model of type 1 diabetes, the nonobese diabetic mouseQ46811766
Evaluating the predictive value of doublecortin as a marker for adult neurogenesis in canaries (Serinus canaria).Q46984510
The effects of weight loss on adipokines and markers of inflammation in dogsQ47347985
Neurogenesis in the septal and temporal part of the adult rat dentate gyrusQ47789240
Effect of monomeric adiponectin on cardiac function and perfusion in anesthetized pig.Q47866376
Detection of adiponectin in cerebrospinal fluid in humansQ48109101
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intakeQ48111745
Improved ELISA for selective measurement of adiponectin multimers and identification of adiponectin in human cerebrospinal fluidQ48122260
TLX activates MASH1 for induction of neuronal lineage commitment of adult hippocampal neuroprogenitorsQ48143025
Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum.Q48301054
Identification of necrotic cell death by the TUNEL assay in the hypoxic-ischemic neonatal rat brainQ48658982
Ultrastructural morphological changes are not characteristic of apoptotic cell death following focal cerebral ischaemia in the rat.Q48944530
Neuronal precursor-specific activity of a human doublecortin regulatory sequenceQ49126350
Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor.Q49159036
Cloning of adiponectin receptors that mediate antidiabetic metabolic effectsQ24304889
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesQ24319848
Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferationQ24564760
Pathways towards and away from Alzheimer's diseaseQ24596270
The nuclear receptor tailless is required for neurogenesis in the adult subventricular zoneQ24646697
TLX: A master regulator for neural stem cell maintenance and neurogenesisQ26999359
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Alzheimer's disease: the cholesterol connectionQ28186482
Brain inflammation and adult neurogenesis: the dual role of microgliaQ28288892
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expressionQ28300071
In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary noteQ28300836
Doublecortin expression levels in adult brain reflect neurogenesisQ28302922
Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomersQ28308082
Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brainQ28504804
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesityQ28506782
Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathwaysQ28507272
Deletion of CPEB3 enhances hippocampus-dependent memory via increasing expressions of PSD95 and NMDA receptorsQ28508301
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30Q28511676
Unlocking mechanisms in interleukin-1β-induced changes in hippocampal neurogenesis--a role for GSK-3β and TLXQ28571565
Area postrema neurons are modulated by the adipocyte hormone adiponectinQ28577642
Expression and function of orphan nuclear receptor TLX in adult neural stem cellsQ28586702
Disruption of adiponectin causes insulin resistance and neointimal formationQ28589597
A Novel Serum Protein Similar to C1q, Produced Exclusively in AdipocytesQ28590335
The Tlx gene regulates the timing of neurogenesis in the cortexQ28592170
Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cellsQ28910201
In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary noteQ29026600
Linking the p53 tumour suppressor pathway to somatic cell reprogrammingQ29616507
Suppression of induced pluripotent stem cell generation by the p53-p21 pathwayQ29619160
Adiponectin and adiponectin receptorsQ29620248
Cognitive dysfunction and diabetes mellitusQ30489305
Glucose levels and risk of dementiaQ30574095
Inhibition of adult hippocampal neurogenesis disrupts contextual learning but spares spatial working memory, long-term conditional rule retention and spatial reversal.Q50761287
Impairment of hippocampal neurogenesis in streptozotocin-treated diabetic rats.Q51971583
Differential expression of PSD proteins in age-related spatial learning impairments.Q52029940
The mouse homolog of the orphan nuclear receptor tailless is expressed in the developing forebrain.Q52538745
Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells.Q53226951
Dementia and Alzheimer disease incidence: a prospective cohort study.Q53251602
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.Q53370119
Cisplatin-mediated c-myc overexpression and cytochrome c (cyt c) release result in the up-regulation of the death receptors DR4 and DR5 and the activation of caspase 3 and caspase 9, likely responsible for the TRAIL-sensitizing effect of cisplatin.Q53570001
Nongenetic mouse models of non-insulin-dependent diabetes mellitus.Q54134954
p21 is associated with the proliferation and apoptosis of bone marrow-derived mesenchymal stem cells from non-obese diabetic mice.Q54394297
Human bone marrow-derived stem cell proliferation is inhibited by hepatocyte growth factor via increasing the cell cycle inhibitors p53, p21 and p27.Q54561700
Chronic Bile Duct Injury Associated with Fibrotic Matrix Microenvironment Provokes Cholangiocarcinoma in p53-Deficient MiceQ58214837
Leptin activates neurons in ventrobasal hypothalamus and brainstemQ72996252
Heterogenous properties of dentate granule neurons in the adult ratQ73367455
Melatonin influences the proliferative and differentiative activity of neural stem cellsQ80170555
Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytesQ80326314
Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulationQ84581239
Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancerQ86100800
Repairing brain after stroke: a review on post-ischemic neurogenesisQ36832625
Leptin-sensitive sensory nerves innervate white fat.Q36923681
Persistent inflammation alters the function of the endogenous brain stem cell compartmentQ36944496
Inflammation: a new candidate in modulating adult neurogenesisQ37024273
Cognition and diabetes: a lifespan perspective.Q37061183
RAGE, diabetes, and the nervous systemQ37106522
Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitusQ37435643
Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysisQ37543864
Mitochondria and diabetes mellitus: untangling a conflictive relationship?Q37612965
Role of transcription factors in neurogenesis after cerebral ischemiaQ37892569
Psychiatric disorders presenting in the elderly with type 2 diabetes mellitusQ37944439
DNA damage checkpoints in stem cells, ageing and cancer.Q38036830
Obesity and psychiatric disorders: commonalities in dysregulated biological pathways and their implications for treatment.Q38107749
DNA damage response in adult stem cellsQ38184042
Role of anti-inflammatory adipokines in obesity-related diseasesQ38205645
The role of the vagus nerve in mediating the long-term anorectic effects of leptinQ38303756
Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonistsQ38318111
Adiponectin acts in the brain to decrease body weight.Q38342591
Diabetes mellitus and risk of Alzheimer disease and decline in cognitive functionQ38422040
Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1.Q40495451
Apolipoprotein A-I activates protein kinase C alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assemblyQ40638196
High glucose upregulation of early-onset Parkinson's disease protein DJ-1 integrates the PRAS40/TORC1 axis to mesangial cell hypertrophyQ42073523
PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neuronsQ42485543
Paraquat inhibits cell viability via enhanced oxidative stress and apoptosis in human neural progenitor cellsQ42709268
Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.Q42798975
A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivityQ42834758
Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama studyQ42925710
NF-kappa B activation mediates doxorubicin-induced cell death in N-type neuroblastoma cellsQ43779020
Increased risk of type 2 diabetes in Alzheimer diseaseQ44745172
Blood rheology and cognition in the Edinburgh Type 2 Diabetes StudyQ44792903
High-fat diet impairs hippocampal neurogenesis in male ratsQ33264117
Superoxide production by mitochondria of insulin-sensitive tissues: mechanistic differences and effect of early diabetesQ33618562
Association between hypoglycemia and dementia in a biracial cohort of older adults with diabetes mellitusQ33699361
Mitochondria-targeted antioxidant peptide SS31 attenuates high glucose-induced injury on human retinal endothelial cellsQ33764006
Nuclear receptor TLX stimulates hippocampal neurogenesis and enhances learning and memory in a transgenic mouse modelQ33834977
High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in miceQ33850466
Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathwayQ33945336
c-Myc target genes involved in cell growth, apoptosis, and metabolismQ33956988
Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neuronsQ34083053
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in miceQ34118282
DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisionsQ34328242
Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolismQ34343566
MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism.Q34353174
Adiponectin and its receptors are expressed in bone-forming cellsQ34353933
cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1).Q34377772
Characterization of TLX expression in neural stem cells and progenitor cells in adult brainsQ34405091
Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptorsQ34434495
Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicityQ34540588
A role for adult TLX-positive neural stem cells in learning and behaviourQ34743630
Myc orchestrates a regulatory network required for the establishment and maintenance of pluripotencyQ35215442
Pulse labeling and long-term tracing of newborn neurons in the adult subgranular zoneQ35348167
p53 upregulated modulator of apoptosis sensitizes drug-resistant U251 glioblastoma stem cells to temozolomide through enhanced apoptosisQ35387486
Adiponectin stimulates proliferation of adult hippocampal neural stem/progenitor cells through activation of p38 mitogen-activated protein kinase (p38MAPK)/glycogen synthase kinase 3β (GSK-3β)/β-catenin signaling cascadeQ35639737
Adiponectin receptor signalling in the brainQ35708104
Diabetes mellitus and the sensory neuronQ35816806
Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cellsQ35846749
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brainQ36088909
Impact of impaired glucose tolerance and type 2 diabetes on cognitive agingQ36291141
Links between cognitive impairment in insulin resistance: an explanatory model.Q36295761
Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive functionQ36325260
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitisQ36404110
Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampusQ36662697
Adiponectin as an anti-inflammatory factorQ36753830
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectneurogenesisQ1456827
neural stem cellQ2944097
P304page(s)e1844
P577publication date2015-08-06
P1433published inCell Death and DiseaseQ2197222
P1476titleAdiponectin receptor-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: an in vivo and in vitro study
P478volume6

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cites work (P2860)
Q47644425Adiponectin and sporadic Alzheimer's disease: Clinical and molecular links.
Q38930497Adiponectin confers protection from acute colitis and restricts a B cell immune response.
Q46288375Adiponectin controls the apoptosis and the expression of tight junction proteins in brain endothelial cells through AdipoR1 under beta amyloid toxicity
Q90458243Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study
Q39382593Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose
Q36444140Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders
Q92814997Metabolic Stress Alters Antioxidant Systems, Suppresses the Adiponectin Receptor 1 and Induces Alzheimer's Like Pathology in Mice Brain
Q48050303Modulating adult neurogenesis through dietary interventions
Q26752744Neuroendorine and Epigentic Mechanisms Subserving Autonomic Imbalance and HPA Dysfunction in the Metabolic Syndrome
Q37418553The role of adipokines in the rapid antidepressant effects of ketamine

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