Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning

scientific article published on 18 July 2013

Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/LM.031666.113
P932PMC publication ID3718201
P698PubMed publication ID23869026
P5875ResearchGate publication ID250920571

P50authorAnis ContractorQ43082668
Craig W. LindsleyQ67215429
P. Jeffrey ConnQ67215432
Shaun R StaufferQ114738637
P2093author name stringJian Xu
Toshihiro Nomura
John J Marshall
Yongling Zhu
Stephen Kraniotis
Qionger He
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Comparison of the mGlu(5) receptor positive allosteric modulator ADX47273 and the mGlu(2/3) receptor agonist LY354740 in tests for antipsychotic-like activityQ43274461
Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1.Q43657512
The endogenous cannabinoid system controls extinction of aversive memoriesQ44085607
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D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learningQ48108159
Ex vivo depotentiation of conditioning-induced potentiation at thalamic input synapses onto the lateral amygdala requires GluN2B-containing NMDA receptorsQ48335068
Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory.Q48436289
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Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memoryQ24617217
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Fear memories require protein synthesis in the amygdala for reconsolidation after retrievalQ28144792
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Memory for fear extinction requires mGluR5-mediated activation of infralimbic neuronsQ30498208
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mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learningQ33908562
Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorderQ34004794
Preventing the return of fear in humans using reconsolidation update mechanismsQ34088107
Memory retrieval and the passage of time: from reconsolidation and strengthening to extinctionQ34753945
mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration.Q34775016
ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activitiQ34815750
Beyond extinction: erasing human fear responses and preventing the return of fearQ34945597
The mGluR5 Positive Allosteric Modulator CDPPB Does Not Alter Extinction or Contextual Reinstatement of Methamphetamine-Seeking Behavior in RatsQ35833718
Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockadeQ35984134
Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes?Q35996918
Erasing fear memories with extinction training.Q36050594
Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and futureQ36571175
Fear extinction induces mGluR5-mediated synaptic and intrinsic plasticity in infralimbic neuronsQ36948897
Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndromeQ37059491
Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophreniaQ37341995
Glutamate receptors as therapeutic targets for Parkinson's diseaseQ37585401
P433issue8
P304page(s)438-445
P577publication date2013-07-18
P1433published inLearning and MemoryQ15765923
P1476titlePotentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning
P478volume20

Reverse relations

cites work (P2860)
Q50431213A preregistered, direct replication attempt of the retrieval-extinction effect in cued fear conditioning in rats.
Q40096876Acute inhibition of mGluR5 disrupts behavioral flexibility
Q30595720Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood.
Q64056208Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses
Q47970224Contextual Fear Extinction Induces Hippocampal Metaplasticity Mediated by Metabotropic Glutamate Receptor 5.
Q38966204Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5
Q33671679Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex.
Q38669576Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research
Q36746407Impact of partial dopamine depletion on cognitive flexibility in BDNF heterozygous mice
Q48955944Kinetic modeling and long-term test-retest reproducibility of the mGluR5 PET tracer 18F-FPEB in human brain.
Q47383203Metabotropic Glutamatergic Receptor 5 and Stress Disorders: Knowledge Gained From Receptor Imaging Studies.
Q64240028Neurochemical and molecular mechanisms underlying the retrieval-extinction effect
Q34399823Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders
Q41846131Pharmacological enhancement of mGluR5 facilitates contextual fear memory extinction
Q35867117mGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal Cortex

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