D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning

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D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning is …
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scholarly articleQ13442814

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P356DOI10.1038/SJ.NPP.1301486
P698PubMed publication ID17625504
P5875ResearchGate publication ID6211689

P2093author name stringSteven Duffy
Viviane Labrie
John C Roder
P2860cites workGenetic enhancement of learning and memory in miceQ22010371
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Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophreniaQ24308818
Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockadeQ24561819
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptorQ24675924
Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophreniaQ28239090
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5Q28282369
Environmental enrichment modifies the PKA-dependence of hippocampal LTP and improves hippocampus-dependent memoryQ28346604
Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding siteQ28505199
Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experienceQ28507227
Mice with reduced NMDA receptor expression display behaviors related to schizophreniaQ28510751
The role of NMDAR subtypes and charge transfer during hippocampal LTP inductionQ28513516
Activation kinetics reveal the number of glutamate and glycine binding sites on the N-methyl-d-aspartate receptorQ48651067
Long-lasting modulation of the induction of LTD and LTP in rat hippocampal CA1 by behavioural stress and environmental enrichmentQ48683601
Behavioural stress facilitates the induction of long-term depression in the hippocampusQ48704490
D-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors.Q48794827
Perseveration on place reversals in spatial swimming pool tasks: further evidence for place learning in hippocampal rats.Q52197248
Glycine potentiates the NMDA response in cultured mouse brain neuronsQ59050531
Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memoryQ28568550
Developmental and regional expression in the rat brain and functional properties of four NMDA receptorsQ28570615
Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampusQ28580737
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmissionQ28590312
Synaptic plasticity and memory: an evaluation of the hypothesisQ29619840
Exaggerated responses to chronic nociceptive stimuli and enhancement of N-methyl-D-aspartate receptor-mediated synaptic transmission in mutant mice lacking D-amino-acid oxidaseQ31680371
Dissecting the behaviour of transgenic mice: is it the mutation, the genetic background, or the environment?Q33933978
NMDA receptor subunits: diversity, development and diseaseQ33950711
Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning.Q33954192
The active role of astrocytes in synaptic transmission.Q34158589
Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine.Q34279149
Components of astrocytic intercellular calcium signalingQ34286914
Hippocampal long-term depression and long-term potentiation encode different aspects of novelty acquisitionQ34332510
Search strategies used by APP transgenic mice during navigation in the Morris water mazeQ34340670
Long-term depression: a cascade of induction and expression mechanisms.Q34349823
The emerging role of glutamate in the pathophysiology and treatment of schizophreniaQ34353738
D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated releaseQ34396311
Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studiesQ34538698
Ion regulation in the brain: implications for pathophysiologyQ34682163
Novelty acquisition is associated with induction of hippocampal long-term depression.Q35563686
Developmental regulation of cognitive abilities: modified composition of a molecular switch turns on associative learningQ36266663
Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation.Q40373486
Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation.Q40395363
Hippocampus, theta, and spatial memoryQ40722747
Homosynaptic LTD and depotentiation: do they differ in name only?Q41173192
Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memoryQ43815520
Studies on the subtype selectivity of CP-101,606: evidence for two classes of NR2B-selective NMDA receptor antagonistsQ43919462
Activity-dependent recruitment of extrasynaptic NMDA receptor activation at an AMPA receptor-only synapse.Q44012230
Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivoQ44306977
Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibitionQ44326776
The effect of (+/-)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermazeQ44582079
Active release of glycine or D-serine saturates the glycine site of NMDA receptors at the cerebellar mossy fibre to granule cell synapseQ44680357
Spatial memory deficits induced by perinatal treatment of rats with PCP and reversal effect of D-serineQ44768742
Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticityQ44895962
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.Q45050775
Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.Q46461038
Induction and activity-dependent reversal of persistent LTP and LTD in lateral perforant path synapses in vivoQ46928065
Delay-dependent impairment of a matching-to-place task with chronic and intrahippocampal infusion of the NMDA-antagonist D-AP5.Q48221570
Contribution of NR2A and NR2B NMDA subunits to bidirectional synaptic plasticity in the hippocampus in vivoQ48402794
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depressionQ48451127
Uptake of D- and L-serine in C6 glioma cellsQ48532041
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectD-SerineQ27077119
P304page(s)1004-1018
P577publication date2007-07-11
P1433published inNeuropsychopharmacologyQ2261280
P1476titleD-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning
P478volume33

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