Blockade of NMDA GluN2B receptors selectively impairs behavioral flexibility but not initial discrimination learning.

scientific article published on 8 March 2011

Blockade of NMDA GluN2B receptors selectively impairs behavioral flexibility but not initial discrimination learning. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1009046271
P356DOI10.1007/S00213-011-2246-Z
P698PubMed publication ID21384103
P5875ResearchGate publication ID50305197

P50authorLiya MaQ63436737
Stan B. FlorescoQ42558961
P2093author name stringGemma L Dalton
Anthony G Phillips
P2860cites workVentral striatal dopamine modulation of different forms of behavioral flexibilityQ46099857
Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasksQ46199208
Systemic and prefrontal cortical NMDA receptor blockade differentially affect discrimination learning and set-shift ability in ratsQ46445122
Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shiftingQ46597031
NMDA receptor subunit NR2A is required for rapidly acquired spatial working memory but not incremental spatial reference memory.Q46667155
Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedureQ46688415
The contribution of NMDA receptors in the dorsolateral striatum to egocentric response learningQ46723588
Differential effects of inactivation of the orbitofrontal cortex on strategy set-shifting and reversal learningQ46870273
Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fearQ46876233
Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specificQ46947214
Dissociable roles for the nucleus accumbens core and shell in regulating set shifting.Q46970963
Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat.Q47353682
NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteinsQ48054784
D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learningQ48108159
Temporal lobe dysfunction in medication-naïve boys with attention-deficit/hyperactivity disorder during attention allocation and its relation to response variabilityQ48129163
Wisconsin Card Sorting Test performance following head injury: dorsolateral fronto-striatal circuit activity predicts perseverationQ48152411
Comparison of set-shifting ability in patients with chronic schizophrenia and frontal lobe damageQ48165305
The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in ratsQ48184350
Further evidence for dementia of the prefrontal type in schizophrenia? A controlled study of teaching the Wisconsin Card Sorting TestQ48186209
Dissociable contributions of the orbitofrontal and infralimbic cortex to pavlovian autoshaping and discrimination reversal learning: further evidence for the functional heterogeneity of the rodent frontal cortex.Q48189835
Involvement of the prelimbic-infralimbic areas of the rodent prefrontal cortex in behavioral flexibility for place and response learning.Q48202603
Effects of orbitofrontal, infralimbic and prelimbic cortical lesions on serial spatial reversal learning in the rat.Q48253276
Contribution of NR2A and NR2B NMDA subunits to bidirectional synaptic plasticity in the hippocampus in vivoQ48402794
Thalamic-prefrontal cortical-ventral striatal circuitry mediates dissociable components of strategy set shiftingQ48424340
In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunitsQ48478071
Separation of .alpha.1-adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compoundsQ48651147
Limbic lesions and the problem of stimulus—Reinforcement associationsQ48738489
Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitroQ48946347
Performance of children with attention deficit hyperactivity disorder (ADHD) on a test battery of impulsiveness.Q51988156
Effects of combined block of alpha 1-adrenoceptors and NMDA receptors on spatial and passive avoidance behavior in rats.Q52048543
The effects of NMDA receptor antagonists at anticonvulsive doses on the performance of rats in the water maze task.Q52054158
The effect of dizocilpine (MK-801) on spatial and visual discrimination tasks in the rat.Q52206675
Characterization of NMDA Receptor Subunit-Specific Antibodies: Distribution of NR2A and NR2B Receptor Subunits in Rat Brain and Ontogenic Profile in the CerebellumQ58868639
Distinct distributions of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrainQ72255109
A nomenclature for ligand-gated ion channelsQ24609005
Cognitive inflexibility after prefrontal serotonin depletionQ28260632
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5Q28282369
Developmental and regional expression in the rat brain and functional properties of four NMDA receptorsQ28570615
Hippocampal long-term depression mediates acute stress-induced spatial memory retrieval impairment.Q30480276
Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learningQ30494493
Antagonists selective for NMDA receptors containing the NR2B subunit.Q33600248
Hippocampal long-term depression is required for the consolidation of spatial memoryQ34151885
Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic reviewQ34425633
Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5.Q34454517
Pharmacological enhancement of memory and executive functioning in laboratory animals.Q34661221
Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockadeQ35984134
Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit.Q36617546
Double dissociation of the effects of medial and orbital prefrontal cortical lesions on attentional and affective shifts in mice.Q37132044
The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasksQ37187494
Neural circuits subserving behavioral flexibility and their relevance to schizophrenia.Q37358594
Learning and cognitive flexibility: frontostriatal function and monoaminergic modulationQ37694837
Immunoblot analyses on the differential distribution of NR2A and NR2B subunits in the adult rat brainQ38529284
The effects of dopamine D(1) receptor blockade in the prelimbic-infralimbic areas on behavioral flexibilityQ39755833
Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunitQ40814537
Regional, developmental and interspecies expression of the four NMDAR2 subunits, examined using monoclonal antibodiesQ41071852
The messenger RNAs for the N-methyl-D-aspartate receptor subunits show region-specific expression of different subunit composition in the human brainQ42522463
Selective lesions of the dorsomedial striatum impair serial spatial reversal learning in ratsQ42599077
A within-subject cognitive battery in the rat: differential effects of NMDA receptor antagonistsQ42949863
Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: a novel NR1/2B subtype selective NMDA receptor antagonistQ43713817
Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set.Q43758984
MK-801 disrupts acquisition of contextual fear conditioning but enhances memory consolidation of cued fear conditioningQ44129784
Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibitionQ44326776
The NMDA-receptor antagonist MK-801 selectively disrupts reversal learning in ratsQ44661035
NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdalaQ44963327
Investigation of the effects of lamotrigine and clozapine in improving reversal-learning impairments induced by acute phencyclidine and D-amphetamine in the rat.Q45220615
Impairment in perceptual attentional set-shifting following PCP administration: a rodent model of set-shifting deficits in schizophreniaQ45245234
P433issue4
P304page(s)525-535
P577publication date2011-03-08
P1433published inPsychopharmacologyQ1422802
P1476titleBlockade of NMDA GluN2B receptors selectively impairs behavioral flexibility but not initial discrimination learning
P478volume216

Reverse relations

cites work (P2860)
Q36883052Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine
Q48091888Adaptive Encoding of Outcome Prediction by Prefrontal Cortex Ensembles Supports Behavioral Flexibility.
Q48606621Ageing effects on path integration and landmark navigation
Q50576520Atomoxetine accelerates attentional set shifting without affecting learning rate in the rat.
Q52308958Behavioral flexibility predicts increased ability to resist excessive methamphetamine self-administration.
Q52318191Calcium chloride mimics the effects of acamprosate on cognitive deficits in chronic alcohol-exposed mice.
Q91867564Can N-Methyl-D-Aspartate Receptor Hypofunction in Schizophrenia Be Localized to an Individual Cell Type?
Q46184244Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models.
Q34292506Chronic alcohol exposure alters behavioral and synaptic plasticity of the rodent prefrontal cortex
Q35234356Conditional loss of GluN2B in cortex and hippocampus impairs attentional set formation
Q40681104Cortical GluN2B deletion attenuates punished suppression of food reward-seeking.
Q58603470Cortico-hippocampal GluN2B is essential for efficient visual-spatial discrimination learning in a touchscreen paradigm
Q47983039Deficits in cognitive flexibility induced by chronic unpredictable stress are associated with impaired glutamate neurotransmission in the rat medial prefrontal cortex
Q36755954Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: reversal with galantamine
Q48215865Effects of acamprosate on attentional set-shifting and cellular function in the prefrontal cortex of chronic alcohol-exposed mice
Q59138279Eradicating Suicide at Its Roots: Preclinical Bases and Clinical Evidence of the Efficacy of Ketamine in the Treatment of Suicidal Behaviors
Q38168191GluA2-dependent AMPA receptor endocytosis and the decay of early and late long-term potentiation: possible mechanisms for forgetting of short- and long-term memories
Q35142924Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors
Q35655709Impaired discrimination learning in interneuronal NMDAR-GluN2B mutant mice
Q30541787LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype
Q42003507Late adolescent expression of GluN2B transmission in the prefrontal cortex is input-specific and requires postsynaptic protein kinase A and D1 dopamine receptor signaling
Q35070172Local N-methyl-d-aspartate receptor antagonism in the prefrontal cortex attenuates spatial cognitive deficits induced by gonadectomy in adult male rats
Q34195167Loss of GluN2A-containing NMDA receptors impairs extra-dimensional set-shifting
Q36566216Loss of dysbindin-1 in mice impairs reward-based operant learning by increasing impulsive and compulsive behavior
Q34139637N-methyl-D-aspartate receptor-mediated glutamate transmission in nucleus accumbens plays a more important role than that in dorsal striatum in cognitive flexibility.
Q33801580NMDA receptor-dependent LTD is required for consolidation but not acquisition of fear memory.
Q43238242NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex
Q30432782NR2B Antagonist CP-101,606 Abolishes Pitch-Mediated Deviance Detection in Awake Rats
Q36123453Neural correlates of rules and conflict in medial prefrontal cortex during decision and feedback epochs
Q27008180Neural structures underlying set-shifting: roles of medial prefrontal cortex and anterior cingulate cortex
Q48313807Neurogenesis enhancer RO 25-6981 facilitates repeated spatial learning in adult rats
Q34473917Performance on a strategy set shifting task in rats following adult or adolescent cocaine exposure.
Q35957258Stress-induced impairments in prefrontal-mediated behaviors and the role of the N-methyl-D-aspartate receptor
Q38775512The neural basis of reversal learning: An updated perspective.
Q36906158Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex

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