Different activation forms of MMP-2 oppositely affect the fate of endothelial cells

scientific article published on 13 January 2010

Different activation forms of MMP-2 oppositely affect the fate of endothelial cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPCELL.00305.2009
P698PubMed publication ID20071690
P5875ResearchGate publication ID41013030

P2093author name stringHaim Bitterman
Nitza Lahat
Ron Auslender
Sarah Shapiro
Olga Khodalev
P2860cites workMatrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic propertiesQ28268723
Structure and function of matrix metalloproteinases and TIMPsQ30014818
Human endothelial gelatinases and angiogenesisQ34317873
TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domainsQ34545340
New insights into the function and regulation of endothelial cell apoptosisQ35712021
Processing, shedding, and endocytosis of membrane type 1-matrix metalloproteinase (MT1-MMP).Q35770288
Metalloproteinases and their inhibitors in tumor angiogenesisQ36053766
Mechanisms of endothelial dysfunction, injury, and deathQ37255202
p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-x(L).Q40533259
Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth factor-beta1-induced pericellular collagenolysisQ40537092
Modulation of phorbol ester-induced regulation of matrix metalloproteinases and tissue inhibitors of metalloproteinases by SB203580, a specific inhibitor of p38 mitogen-activated protein kinaseQ40716284
Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM.Q41832788
Phosphorylation of p38 mitogen-activated protein kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cellsQ43618959
MT1-MMP-dependent and -independent regulation of gelatinase A activation in long-term, ascorbate-treated fibroblast cultures: regulation by fibrillar collagenQ43845368
Inhibition of programmed cell death impairs in vitro vascular-like structure formation and reduces in vivo angiogenesis.Q44012013
Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2.Q44116626
p38 MAPK inhibition is critically involved in VEGFR-2-mediated endothelial cell survivalQ44480233
Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin.Q45938289
Activation of p38 has opposing effects on the proliferation and migration of endothelial cellsQ46404136
Activation of metalloproteinases and their association with integrins: an auxiliary apoptotic pathway in human endothelial cells.Q51033758
MAPK signaling regulates endothelial cell assembly into networks and expression of MT1-MMP and MMP-2.Q52560874
Hypoxia-induced apoptosis and tube breakdown are regulated by p38 MAPK but not by caspase cascade in an in vitro capillary model composed of human endothelial cells.Q53564610
Hypoxia induces apoptosis of HUVECs in an in vitro capillary model by activating proapoptotic signal p38 through suppression of ERK1/2.Q53570889
Nitric oxide and p38 MAP kinase mediate shear stress-dependent inhibition of MMP-2 production in microvascular endothelial cells.Q53629670
P433issue4
P921main subjectendotheliumQ111140
P304page(s)C942-51
P577publication date2010-01-13
P1433published inAmerican Journal of Physiology - Cell PhysiologyQ2227080
P1476titleDifferent activation forms of MMP-2 oppositely affect the fate of endothelial cells
P478volume298

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cites work (P2860)
Q34334378Ablation of EIF5A2 induces tumor vasculature remodeling and improves tumor response to chemotherapy via regulation of matrix metalloproteinase 2 expression
Q30408109Annexin II-dependent actin remodelling evoked by hydrogen peroxide requires the metalloproteinase/sphingolipid pathway
Q46053599Differential regulation of collagen, lysyl oxidase and MMP-2 in human periodontal ligament cells by low- and high-level mechanical stretching
Q51242582Feline Injection-Site Sarcoma.
Q41435242Hypoxia induces calpain activity and degrades SMAD2 to attenuate TGFβ signaling in macrophages
Q48061925Inhibition of Gelatinases (MMP-2 and MMP-9) by Withania somnifera Phytochemicals Confers Neuroprotection in Stroke: An In Silico Analysis.
Q37784801Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases.
Q35175533Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis
Q36960275Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling
Q38871902Multidimensional Contribution of Matrix Metalloproteinases to Atherosclerotic Plaque Vulnerability: Multiple Mechanisms of Inhibition to Promote Stability
Q35007715Physiology and pathophysiology of matrix metalloproteases.
Q39621316Reduced TIMP-2 in hypoxia enhances angiogenesis
Q37414161Superficial Burn Wound Healing with Intermittent Negative Pressure Wound Therapy Under Limited Access and Conventional Dressings
Q27303955TIMP-2 fusion protein with human serum albumin potentiates anti-angiogenesis-mediated inhibition of tumor growth by suppressing MMP-2 expression

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