NHERF1: molecular brake on the PI3K pathway in breast cancer

scientific article published on 18 April 2008

NHERF1: molecular brake on the PI3K pathway in breast cancer is …
instance of (P31):
editorialQ871232
scholarly articleQ13442814

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P6179Dimensions Publication ID1028810011
P356DOI10.1186/BCR1992
P932PMC publication ID2397532
P698PubMed publication ID18430260
P5875ResearchGate publication ID5423099

P2093author name stringMaria-Magdalena Georgescu
P2860cites workPhosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targetsQ24294974
PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signalingQ24303571
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinomaQ28243071
Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestineQ28510081
Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wastingQ28510488
Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 organizes ERM proteins at the apical membrane of polarized epitheliaQ28588034
Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cellsQ28592252
Nuclear speckles and nucleoli targeting by PIP2-PDZ domain interactionsQ30476030
The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.Q30479321
Suppression of breast cancer cell growth by Na+/H+ exchanger regulatory factor 1 (NHERF1)Q35633702
NHE-RF, a merlin-interacting protein, is primarily expressed in luminal epithelia, proliferative endometrium, and estrogen receptor-positive breast carcinomasQ35746077
A phase II trial of imatinib mesylate monotherapy in patients with metastatic breast cancer.Q43487632
NHERF (Na+/H+ exchanger regulatory factor) gene mutations in human breast cancerQ45092731
Estrogen receptor regulation of the Na+/H+ exchange regulatory factorQ77932795
Expression and clinicopathological significance of oestrogen-responsive ezrin-radixin-moesin-binding phosphoprotein 50 in breast cancerQ80530484
P433issue2
P304page(s)106
P577publication date2008-04-18
P1433published inBreast Cancer ResearchQ2208481
P1476titleNHERF1: molecular brake on the PI3K pathway in breast cancer
P478volume10

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cites work (P2860)
Q34432747Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles
Q35141564Apical membrane segregation of phosphatidylinositol-4,5-bisphosphate influences parathyroid hormone 1 receptor compartmental signaling and localization via direct regulation of ezrin in LLC-PK1 cells
Q24323184Breast cancer-derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet-derived growth factor receptor signaling
Q37150777Ezrin-radixin-moesin-binding phosphoprotein (EBP50), an estrogen-inducible scaffold protein, contributes to biliary epithelial cell proliferation
Q33423808Identification of a putative protein profile associated with tamoxifen therapy resistance in breast cancer
Q93335769Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells
Q92005259NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland
Q39459665Na(+)/H(+) Exchanger Regulatory Factor 1 (NHERF1) Is Required for the Estradiol-Dependent Increase of Phosphatase and Tensin Homolog (PTEN) Protein Expression
Q24629682PDZ domains and their binding partners: structure, specificity, and modification
Q34202681PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control
Q36211287PTEN inhibits macrophage polarization from M1 to M2 through CCL2 and VEGF-A reduction and NHERF-1 synergism
Q33918198Pro-oncogenic and anti-oncogenic pathways: opportunities and challenges of cancer therapy
Q36066974Prognostic significance of peroxiredoxin 1 and ezrin-radixin-moesin-binding phosphoprotein 50 in cholangiocarcinoma
Q39076960Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance.
Q36808215SLC9A3R1 stimulates autophagy via BECN1 stabilization in breast cancer cells
Q38714954The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2.

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