The methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance

scientific article published in May 2006

The methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/CNCR.21870
P698PubMed publication ID16598757
P5875ResearchGate publication ID7180516

P50authorHidetaka UramotoQ92854230
Takeshi HanagiriQ110679760
P2093author name stringTsunehiro Oyama
Masaru Morita
Kosei Yasumoto
Kenji Sugio
Shoji Nakata
P2860cites workEpigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppressionQ24291194
Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasisQ24292072
WNT7a induces E-cadherin in lung cancer cellsQ24317695
The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancersQ24321912
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islandsQ24631957
CpG island methylator phenotype in colorectal cancerQ24672170
Promoter methylation status of E-cadherin, hMLH1, and p16 genes in nonneoplastic gastric epitheliaQ28216984
Revisions in the International System for Staging Lung CancerQ28241070
How many tumor suppressor genes are involved in human lung carcinogenesis?Q33699741
DNA hypermethylation in tumorigenesis: epigenetics joins geneticsQ33870798
Molecular and genetic aspects of lung cancerQ33891465
Molecular genetic abnormalities in the pathogenesis of human lung cancerQ34249055
Reactivating the expression of methylation silenced genes in human cancerQ34770617
Inactivation of the E-cadherin-mediated cell adhesion system in human cancersQ35753235
K-ras and p53 mutations are an independent unfavourable prognostic indicator in patients with non-small-cell lung cancerQ36420159
Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogensQ36550875
Cancer and the FRA3B/FHIT fragile locus: it's a HITQ36648921
Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinomaQ38481338
Frequent aberrant methylation of p16INK4a in primary rat lung tumorsQ40021115
Prognostic analysis of E-cadherin gene promoter hypermethylation in patients with surgically resected, node-positive, diffuse gastric cancer.Q40515553
Induction of DNA methylation and gene silencing by short interfering RNAs in human cellsQ40525501
Aberrant methylation of the FHIT gene in chronic smokers with early stage squamous cell carcinoma of the lungQ44961920
Expression of deltaNp73 predicts poor prognosis in lung cancerQ45122006
Antisense MBD2 gene therapy inhibits tumorigenesisQ45887897
Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epitheliaQ47835975
Prognostic value of the immunohistochemical detection of p16INK4 expression in nonsmall cell lung carcinomaQ50944026
DNA methylation and expression of p16(INK4A) gene in pulmonary adenocarcinoma and anthracosis in background lung.Q53416798
Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers.Q54765745
Frequent epigenetic silencing of the p16 gene in non-small cell lung cancers of tobacco smokers.Q55383295
Promoter Methylation and Silencing of the Retinoic Acid Receptor- Gene in Lung CarcinomasQ57890923
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colonQ72781919
Prognostic impact of telomerase activity in non-small cell lung cancersQ73181191
Prognosis and survival after resection for bronchogenic carcinoma based on the 1997 TNM-staging classification: the Japanese experienceQ74099120
Micrometastasis in the bone marrow of patients with lung cancer associated with a reduced expression of E-cadherin and beta-catenin: risk assessment by immunohistochemistryQ77580030
Hypermethylation in promoter region of E-cadherin gene is associated with tumor dedifferention and myometrial invasion in endometrial carcinomaQ78892631
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectlung carcinomaQ18556110
P304page(s)2190-2199
P577publication date2006-05-01
P1433published inCancerQ326041
P1476titleThe methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance
P478volume106

Reverse relations

cites work (P2860)
Q53559080Aberrant methylation of E-cadherin and H-cadherin genes in nonsmall cell lung cancer and its relation to clinicopathologic features.
Q35068319Association of promoter methylation with histologic type and pleural indentation in non-small cell lung cancer (NSCLC).
Q34295621Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer
Q34103461Cigarette smoking and p16INK4α gene promoter hypermethylation in non-small cell lung carcinoma patients: a meta-analysis
Q28472991Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis
Q30494942DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type
Q34133706DNA methylation of cancer genome.
Q28386334DNA methylation-based biomarkers for early detection of non-small cell lung cancer: an update
Q37997493Emerging evidence of epithelial-to-mesenchymal transition in lung carcinogenesis
Q33874587Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas
Q26996766Epigenetics of lung cancer
Q39771185Fhit regulates invasion of lung tumor cells
Q28385454Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma
Q35643951Hepatitis B virus infection in hepatocellular carcinoma tissues upregulates expression of DNA methyltransferases
Q39084419High pesticide exposure events and DNA methylation among pesticide applicators in the agricultural health study
Q39785520Infrequently methylated event at sites -181 to -9 within the 5' CpG island of E-cadherin in non-small cell lung cancer
Q39709698Insights into the role of DNA methylation in disease through the use of mouse models
Q91980450Long non-coding RNA H19 is responsible for the progression of lung adenocarcinoma by mediating methylation-dependent repression of CDH1 promoter
Q35160337Meta-analyses of gene methylation and smoking behavior in non-small cell lung cancer patients
Q36217021Methylation of the DLEC1 gene correlates with poor prognosis in Japanese lung cancer patients
Q37963519Molecular changes in smoking-related lung cancer
Q45857727Overexpression of c-erbB-2 and loss of p16 have molecular diagnostic relevance but no prognostic value in lung cancer
Q33759917Pellino-1 promotes lung carcinogenesis via the stabilization of Slug and Snail through K63-mediated polyubiquitination
Q42254406Promoter hypermethylation of p14 (ARF) , RB, and INK4 gene family in hepatocellular carcinoma with hepatitis B virus infection
Q28253632Promoter methylation and loss of p16(INK4a) gene expression in head and neck cancer
Q34513567Promoter methylation-mediated silencing of β-catenin enhances invasiveness of non-small cell lung cancer and predicts adverse prognosis
Q51633333RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China.
Q53048458Recent advances in epigenomics in NSCLC: real-time detection and therapeutic implications.
Q38002967Targeting epigenetic mediators of gene expression in thoracic malignancies.
Q34785439The Prognostic Value of p16 Hypermethylation in Cancer: A Meta-Analysis
Q28068822The clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature review
Q41252193The clinicopathological significance and potential drug target of E-cadherin in NSCLC.
Q36500848The clinicopathological significance of FHIT hypermethylation in non-small cell lung cancer, a meta-analysis and literature review
Q34571504The prognostic value of epigenetic silencing of p16 gene in NSCLC patients: a systematic review and meta-analysis
Q36457427The significance of epigenetic alterations in lung carcinogenesis
Q34029138Transcription factors related to epithelial mesenchymal transition in tumor center and margin in invasive lung adenocarcinoma
Q55427539[Advances of DNA methylation in early diagnosis of lung cancer].

Search more.