Intrahepatic MxA and PKR protein expression in chronic hepatitis C virus infection

scientific article

Intrahepatic MxA and PKR protein expression in chronic hepatitis C virus infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JMV.10182
P698PubMed publication ID12210408

P2093author name stringGary P Jeffrey
W Bastiaan de Boer
Kieran A McCaul
Jane E Allan
Michael A Platten
Gerry C MacQuillan
William D Reed
P2860cites workPredictors of the efficacy of interferon therapy in chronic hepatitis C virus infection. Tokyo-Chiba Hepatitis Research GroupQ42984083
Interferon-alpha inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathwayQ43030367
Antibodies developing against a single recombinant interferon protein may neutralize many other interferon-alpha subtypes.Q43038858
Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (IQ45752944
Isolation of the interferon-inducible RNA-dependent protein kinase Pkr promoter and identification of a novel DNA element within the 5'-flanking region of human and mouse Pkr genes.Q45949957
Inhibition of the interferon-inducible protein kinase PKR by HCV E2 proteinQ22010192
Enhanced expression of interferon-regulated genes in the liver of patients with chronic hepatitis C virus infection: detection by suppression-subtractive hybridizationQ24529053
Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulationQ27469500
Histological grading and staging of chronic hepatitisQ29619625
The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study TeamQ29619749
Molecular and functional analysis of the virus- and interferon-inducible human MxA promoterQ33261592
Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activityQ33931051
Mechanism of interferon action: autoregulation of RNA-dependent P1/eIF-2 alpha protein kinase (PKR) expression in transfected mammalian cellsQ37299425
MxA gene expression after live virus vaccination: a sensitive marker for endogenous type I interferonQ40703041
Expression of hepatitis C virus NS5A natural mutants in a hepatocytic cell line inhibits the antiviral effect of interferon in a PKR-independent mannerQ40801087
Correlation of interferon-induced expression of MxA mRNA in peripheral blood mononuclear cells with the response of patients with chronic active hepatitis C to IFN-alpha therapyQ40816503
Hepatitis C virus NS5A protein inhibits interferon antiviral activity, but the effects do not correlate with clinical responseQ40921231
The double-stranded RNA-dependent protein kinase PKR: structure and functionQ41614652
Mx genes show weaker primary response to virus than other interferon-regulated genesQ41649414
In vivo and in vitro induction of MxA protein in peripheral blood mononuclear cells from patients chronically infected with hepatitis C virusQ42474311
P433issue2
P921main subjectHepatitis C virusQ708693
chronic hepatitis CQ55779873
chronic hepatitisQ62019625
P304page(s)197-205
P577publication date2002-10-01
P1433published inJournal of Medical VirologyQ15716684
P1476titleIntrahepatic MxA and PKR protein expression in chronic hepatitis C virus infection
P478volume68

Reverse relations

cites work (P2860)
Q84130039Cell-type specific interferon stimulated gene staining in liver underlies response to interferon therapy in chronic HBV infected patients
Q21245110Differential expression of interferon-induced microRNAs in patients with chronic hepatitis C virus infection treated with pegylated interferon alpha
Q57632335Expression of biomarkers of interferon type I in patients suffering from chronic diseases
Q38435429Expression of toll-like receptors and type 1 interferon specific protein MxA in biliary atresia
Q27490906Genomic scale analysis of racial impact on response to IFN-alpha
Q35136312Hepatic SOCS3 expression is strongly associated with non-response to therapy and race in HCV and HCV/HIV infection
Q34190570Hepatitis C virus infection impairs IRF-7 translocation and Alpha interferon synthesis in immortalized human hepatocytes
Q36749431Hepatitis C virus infection--pathobiology and implications for new therapeutic options
Q42995363Hepatitis C virus inhibits intracellular interferon alpha expression in human hepatic cell lines
Q42990438Hepatocellular MxA protein expression supports the differentiation of recurrent hepatitis C disease from acute cellular rejection after liver transplantation
Q35675878IFN-λ: A New Class of Interferon with Distinct Functions-Implications for Hepatitis C Virus Research
Q36367633Implication of protein kinase R gene quantification in hepatitis C virus genotype 4 induced hepatocarcinogenesis
Q44286199Interferon-stimulated gene expression in black and white hepatitis C patients during peginterferon alfa-2a combination therapy
Q50569910Intrahepatic interferon-stimulated gene responses: can they predict treatment responses in chronic hepatitis C infection?
Q40179377MxA Is A Positive Regulator of Type I IFN Signaling in HCV Infection.
Q29620681Novel insights into hepatitis C virus replication and persistence
Q39702101Preparation of polyclonal antibody against human MxA protein and its specificity to diversified myxovirus resistant protein A.
Q34082923Ribavirin enhances IFN-α signalling and MxA expression: a novel immune modulation mechanism during treatment of HCV.
Q45382415Ultra-structural localisation of hepatocellular PKR protein using immuno-gold labelling in chronic hepatitis C virus disease
Q43048844Upregulation of endogenous intrahepatic interferon stimulated genes during chronic hepatitis C virus infection

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