G protein-coupled receptors desensitize and down-regulate epidermal growth factor receptors in renal mesangial cells

scientific article published on 22 May 2001

G protein-coupled receptors desensitize and down-regulate epidermal growth factor receptors in renal mesangial cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M103578200
P698PubMed publication ID11371570

P2093author name stringLuttrell LM
Grewal JS
Raymond JR
P2860cites workMetalloprotease-disintegrin MDC9: intracellular maturation and catalytic activityQ22008720
The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptorQ22253381
Role of clathrin-mediated endocytosis in agonist-induced down-regulation of the beta2-adrenergic receptorQ24318356
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transductionQ24338592
A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.Q24533465
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptorQ28609951
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGFQ29619098
Angiotensin II stimulates ERK via two pathways in epithelial cells: protein kinase C suppresses a G-protein coupled receptor-EGF receptor transactivation pathwayQ30448357
Regulation of tyrosine kinase cascades by G-protein-coupled receptors.Q33597362
The EGF receptor as central transducer of heterologous signalling systemsQ33781842
The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activityQ33887177
Using green fluorescent proteins to study G-protein-coupled receptor localization and traffickingQ33901020
Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblastsQ34248300
Stabilization of clathrin coated vesicles by amantadine, tromantadine and other hydrophobic aminesQ34883421
Inhibition of receptor-mediated but not fluid-phase endocytosis in polymorphonuclear leukocytesQ36213773
Dual pathways of internalization of the cholecystokinin receptorQ36235452
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.Q37105461
Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptorsQ37685971
Structural basis for epidermal growth factor receptor functionQ38218853
Slow troponin C gene expression in chicken heart and liver is regulated by similar enhancersQ38359454
Endocytosis of functional epidermal growth factor receptor-green fluorescent protein chimeraQ39482370
Essential role of dynamin in internalization of M2 muscarinic acetylcholine and angiotensin AT1A receptorsQ40881329
Beta(2)-adrenergic receptor down-regulation. Evidence for a pathway that does not require endocytosis.Q40925741
Role of heterotrimeric G-proteins in epidermal growth factor signallingQ40926251
Intensification of growth factor receptor signalling by phorbol treatment of ligand-primed cells implies a dimer-stabilizing effect of protein kinase C-dependent juxtamembrane domain phosphorylationQ40947634
Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signalingQ40982696
Downregulation of protein kinase C by phorbol ester increases expression of epidermal growth factor receptors in transformed trophoblasts and amplifies human chorionic gonadotropin productionQ41002082
Tyrosine phosphorylation of GSalpha and inhibition of bradykinin-induced activation of the cyclic AMP pathway in A431 cells by epidermal growth factor receptorQ41145828
Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptorsQ41229236
G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.Q41238078
EGF receptor-mediated signals are differentially modulated by concanavalin A.Q41391761
Adenovirus and protein kinase C have distinct molecular requirements for regulating epidermal growth factor receptor trafficking.Q41510963
Second messenger modulation of epidermal growth factor receptor function does not occur at the level of receptor dimerizationQ41719703
The platelet-derived-growth-factor receptor, not the epidermal-growth-factor receptor, is used by lysophosphatidic acid to activate p42/44 mitogen-activated protein kinase and to induce prostaglandin G/H synthase-2 in mesangial cellsQ41788352
Signal characteristics of G protein-transactivated EGF receptorQ41960343
Rapid activation of sodium-proton exchange and extracellular signal-regulated protein kinase in fibroblasts by G protein-coupled 5-HT1A receptor involves distinct signalling cascades.Q42159389
Inverse regulation of oestrogen receptor and epidermal growth factor receptor gene expression in MCF-7 breast cancer cells treated with phorbol ester.Q42524233
Specific desensitization of the epidermal growth factor receptor by pp60v-srcQ42797810
Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C.Q42812845
Rapid and Long Term Effects of Protein Kinase C on Receptor Tyrosine Kinase Phosphorylation and DegradationQ42825228
Antimitogenic actions of lectins in cultured human fibroblastsQ45077132
Carbachol stimulates transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T84 cells. Implications for carbachol-stimulated chloride secretionQ46096890
Angiotensin II type 1 receptor-induced extracellular signal-regulated protein kinase activation is mediated by Ca2+/calmodulin-dependent transactivation of epidermal growth factor receptorQ47904445
Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormonesQ59077502
P433issue29
P407language of work or nameEnglishQ1860
P921main subjectmesangial cellQ3331086
G protein-coupled receptorQ38173
P304page(s)27335-27344
P577publication date2001-05-22
P1433published inJournal of Biological ChemistryQ867727
P1476titleG protein-coupled receptors desensitize and down-regulate epidermal growth factor receptors in renal mesangial cells
P478volume276

Reverse relations

cites work (P2860)
Q33818158A differential role for endocytosis in receptor-mediated activation of Nox1.
Q34677473Activation and targeting of mitogen-activated protein kinases by G-protein-coupled receptors.
Q47746078Activation of extracellular signal-regulated kinase mediates bombesin-induced mitogenic responses in prostate cancer cells
Q42400187Angiotensin receptor type 1 antagonists protect against neuronal injury induced by oxygen-glucose depletion
Q45853275Bradykinin inhibits high glucose- and growth factor-induced collagen synthesis in mesangial cells through the B2-kinin receptor
Q40687990Dependence of gonadotropin-releasing hormone-induced neuronal MAPK signaling on epidermal growth factor receptor transactivation
Q39787535Down-regulation of c-Cbl by morphine accounts for persistent ERK1/2 signaling in delta-opioid receptor-expressing HEK293 cells
Q28578361ERK is regulated by sodium-proton exchanger in rat aortic vascular smooth muscle cells
Q38722135Lipoxins inhibit Akt/PKB activation and cell cycle progression in human mesangial cells
Q34187552Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT2A or 5-HT2C receptors
Q35068069Receptor tyrosine kinase transactivation: fine-tuning synaptic transmission
Q28266829Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors
Q47758727Role of lysophosphatidic acid and its receptors in the kidney
Q41452150Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease
Q39061953Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor