Activation of extracellular signal-regulated kinase mediates bombesin-induced mitogenic responses in prostate cancer cells

scientific article

Activation of extracellular signal-regulated kinase mediates bombesin-induced mitogenic responses in prostate cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0898-6568(03)00059-7
P698PubMed publication ID12873708

P2093author name stringDongmei Xiao
H Christian Weber
Xiangping Qu
P2860cites workSignal transduction pathways in the mitogenic response to G protein-coupled neuropeptide receptor agonistsQ22009085
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Neuroendocrine cells in tumour growth of the prostateQ33871591
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The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoterQ33937668
Galpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras.Q34148749
Neuropeptides as growth factors for normal and cancerous cellsQ34563386
The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptorsQ36323845
Bombesin specifically induces intracellular calcium mobilization via gastrin-releasing peptide receptors in human prostate cancer cellsQ38357065
Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway.Q40715808
Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activationQ40735099
Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophyQ40747279
EGF receptor function is required in late G(1) for cell cycle progression induced by bombesin and bradykininQ40786481
Potentiation of the inhibitory effect of growth hormone-releasing hormone antagonists on PC-3 human prostate cancer by bombesin antagonists indicative of interference with both IGF and EGF pathwaysQ40869861
beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-RafQ40875727
Mammalian bombesin receptorsQ40928891
Luteinizing hormone-releasing hormone antagonist Cetrorelix (SB-75) and bombesin antagonist RC-3940-II inhibit the growth of androgen-independent PC-3 prostate cancer in nude miceQ41097702
Inhibition of growth of androgen-independent DU-145 prostate cancer in vivo by luteinising hormone-releasing hormone antagonist Cetrorelix and bombesin antagonists RC-3940-II and RC-3950-II.Q41105921
Bombesin and neuromedin B stimulate the activation of p42(mapk) and p74(raf-1) via a protein kinase C-independent pathway in Rat-1 cellsQ41110085
Calcium signaling in prostate cancer cells: evidence for multiple receptors and enhanced sensitivity to bombesin/GRP.Q41127371
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Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancerQ41362569
Characterization of high-affinity receptors for bombesin/gastrin releasing peptide on the human prostate cancer cell lines PC-3 and DU-145: internalization of receptor bound 125I-(Tyr4) bombesin by tumor cellsQ41456961
Effect of somatostatin analog RC-160 and bombesin/gastrin releasing peptide antagonist RC-3095 on growth of PC-3 human prostate-cancer xenografts in nude miceQ41509823
Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cellsQ42120264
In situ hybridization for gastrin-releasing peptide receptor (GRP receptor) expression in prostatic carcinomaQ42451938
Activation of MAP kinases in growth responsive pancreatic cancer cellsQ42475763
Characterization of Ca2+ channels involved in ET-1-induced transactivation of EGF receptorsQ42527757
Reduced requirement of mitogen-activated protein kinase (MAPK) activity for entry into the S phase of the cell cycle in Swiss 3T3 fibroblasts stimulated by bombesin and insulinQ42809756
G protein-coupled receptors desensitize and down-regulate epidermal growth factor receptors in renal mesangial cellsQ43616468
Beta-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinasesQ44016918
Bombesin stimulates the motility of human prostate-carcinoma cells through tyrosine phosphorylation of focal adhesion kinase and of integrin-associated proteins.Q52526626
Bombesin-induced pancreatic regeneration in pigs is mediated by p46Shc/p52Shc and p42/p44 mitogen-activated protein kinase upregulation.Q54198873
Bombesin stimulates growth of human prostatic cancer cells in vitroQ69337614
In vivo inhibition of PC-3 human androgen-independent prostate cancer by a targeted cytotoxic bombesin analogue, AN-215Q73141867
Presence of receptors for bombesin/gastrin-releasing peptide and mRNA for three receptor subtypes in human prostate cancersQ73459534
Bombesin activates MAP kinase in non-small cell lung cancer cellsQ74657987
Distinct calcium-dependent pathways of epidermal growth factor receptor transactivation and PYK2 tyrosine phosphorylation in PC12 cellsQ78010436
Activation of mitogen-activated protein kinase by the A(2A)-adenosine receptor via a rap1-dependent and via a p21(ras)-dependent pathwayQ78177571
P433issue10
P921main subjectprostate cancerQ181257
P1104number of pages9
P304page(s)945-953
P577publication date2003-10-01
P1433published inCellular SignallingQ1524097
P1476titleActivation of extracellular signal-regulated kinase mediates bombesin-induced mitogenic responses in prostate cancer cells
P478volume15