Evidence for distinct conformations of the two alpha 1 subunits in diazepam-bound GABA(A) receptors

scientific article

Evidence for distinct conformations of the two alpha 1 subunits in diazepam-bound GABA(A) receptors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0028-3908(01)00099-5
P698PubMed publication ID11587708
P5875ResearchGate publication ID240161934

P50authorMyles H. AkabasQ42684151
P2093author name stringWilliams DB
P2860cites workGeneral anaesthetic actions on ligand-gated ion channelsQ24595524
Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neuronsQ24616501
Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transferQ30667258
Structure and subunit composition of GABA(A) receptors.Q33682493
Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels.Q33937793
Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptorsQ34171714
GABAA receptor channelsQ40389943
From ion currents to genomic analysis: recent advances in GABAA receptor research.Q40956408
Molecular dissection of benzodiazepine binding and allosteric coupling using chimeric gamma-aminobutyric acidA receptor subunits.Q41060386
Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptorsQ41113769
Stoichiometry and assembly of a recombinant GABAA receptor subtype.Q41116066
Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins.Q41142209
Effect of a benzodiazepine (chlordiazepoxide) on a GABAA receptor from rat brain. Requirement of only one bound GABA molecule for channel openingQ48430944
Mapping the agonist binding site of the GABAA receptor: evidence for a beta-strand.Q48915827
Stoichiometry of a recombinant GABAA receptor.Q48938346
Key amino acids in the gamma subunit of the gamma-aminobutyric acidA receptor that determine ligand binding and modulation at the benzodiazepine siteQ48950667
GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbitalQ49124909
Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms.Q50720910
Benzodiazepines induce a conformational change in the region of the gamma-aminobutyric acid type A receptor alpha(1)-subunit M3 membrane-spanning segment.Q50722415
Direct evidence for diazepam modulation of GABAA receptor microscopic affinity.Q51580752
Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture.Q51640586
The major site of photoaffinity labeling of the gamma-aminobutyric acid type A receptor by [3H]flunitrazepam is histidine 102 of the alpha subunit.Q53725650
Kinetics of the reaction of p-chloromercuribenzoate with the sulfhydryl groups of glutathione, 2-mercaptoethanol, and phosphorylase bQ71821432
P433issue5
P921main subjectdiazepamQ210402
P1104number of pages7
P304page(s)539-545
P577publication date2001-10-01
P1433published inNeuropharmacologyQ15332439
P1476titleEvidence for distinct conformations of the two alpha 1 subunits in diazepam-bound GABA(A) receptors
P478volume41

Reverse relations

cites work (P2860)
Q38498708A mutant residue in the third transmembrane region of the GABA(A) alpha1 subunit causes increased agonistic neurosteroid responses
Q42628316Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics
Q24683541Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment
Q39002171Differential effects of short- and long-term zolpidem treatment on recombinant α1β2γ2s subtype of GABA(A) receptors in vitro
Q45136842Functional and structural analysis of the GABAA receptor alpha 1 subunit during channel gating and alcohol modulation
Q34365717GABAA receptor structure-function studies: a reexamination in light of new acetylcholine receptor structures
Q35773459Safety of Diastat, a rectal gel formulation of diazepam for acute seizure treatment
Q36248043Sites of alcohol and volatile anesthetic action on glycine receptors
Q44115022Structural evidence that propofol stabilizes different GABA(A) receptor states at potentiating and activating concentrations.
Q36299672The location of a closed channel gate in the GABAA receptor channel.