Mutant p53(R270H) gain of function phenotype in a mouse model for oncogene-induced mammary carcinogenesis

scientific article published in April 2008

Mutant p53(R270H) gain of function phenotype in a mouse model for oncogene-induced mammary carcinogenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/IJC.23317
P698PubMed publication ID18092324
P5875ResearchGate publication ID5757320

P2093author name stringJürgen Löhler
Wolfgang Deppert
Christina Heinlein
Genrich V Tolstonog
Frauke Krepulat
Daniel Speidel
P2860cites workDevelopment of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndromeQ35829654
Probing p53 biological functions through the use of genetically engineered mouse modelsQ36204567
The large T antigen of simian virus 40 binds and inactivates p53 but not p73.Q45751922
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectcarcinogenesisQ1637543
P304page(s)1701-1709
P577publication date2008-04-01
P1433published inInternational Journal of CancerQ332492
P1476titleMutant p53(R270H) gain of function phenotype in a mouse model for oncogene-induced mammary carcinogenesis
P478volume122

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cites work (P2860)
Q34618971A rapid and optimization-free procedure allows the in vivo detection of subtle cell cycle and ploidy alterations in tissues by flow cytometry
Q36629345An inducible transgenic mouse breast cancer model for the analysis of tumor antigen specific CD8+ T-cell responses
Q83729340Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms
Q37665460CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo
Q53287381CEACAM1 creates a pro-angiogenic tumor microenvironment that supports tumor vessel maturation.
Q38934976Chemotherapy of WAP-T mouse mammary carcinomas aggravates tumor phenotype and enhances tumor cell dissemination
Q34965421Clinical relevance of gain-of-function mutations of p53 in high-grade serous ovarian carcinoma
Q35238838Epithelial-mesenchymal plasticity is a decisive feature for the metastatic outgrowth of disseminated WAP-T mouse mammary carcinoma cells
Q89805344Gain-of-Function Mutations in p53 in Cancer Invasiveness and Metastasis
Q82852435Genotoxic exposure: novel cause of selection for a functional ΔN-p53 isoform
Q52647660Identification of p53 and its isoforms in human breast carcinoma cells.
Q41924363Immunotherapy of WAP-TNP mice with early stage mammary gland tumors
Q34123850Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo
Q39294303Low-grade and high-grade mammary carcinomas in WAP-T transgenic mice are independent entities distinguished by Met expression
Q33682960Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation
Q33399356Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences
Q33687048Mutant p53 gain-of-function in cancer
Q38959098Mutant p53 promotes epithelial-mesenchymal plasticity and enhances metastasis in mammary carcinomas of WAP-T mice
Q35729171Mutant p53 protein expression and antioxidant status deficiency in breast cancer
Q41490261Mutant p53 stimulates cell invasion through an interaction with Rad21 in human ovarian cancer cells
Q36293880Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF).
Q37903701Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis
Q38417021New insight on the biological role of p53 protein as a tumor suppressor: re-evaluation of its clinical significance in triple-negative breast cancer
Q52584348Potential therapeutic targets of TP53 gene in the context of its classically canonical functions and its latest non-canonical functions in human cancer.
Q37273304Recent advances in p53 research: an interdisciplinary perspective.
Q37002268Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations
Q37662081T-cell epitope strength in WAP-T mouse mammary carcinomas is an important determinant in PD1/PD-L1 immune checkpoint blockade therapy.
Q26772237The Contrived Mutant p53 Oncogene - Beyond Loss of Functions
Q42397956The Expression Levels of XLF and Mutant P53 Are Inversely Correlated in Head and Neck Cancer Cells.
Q27686765The rebel angel: mutant p53 as the driving oncogene in breast cancer
Q89460168The role of TP53 gain-of-function mutation in multifocal glioblastoma
Q34153014The role of mutant p53 in human cancer
Q47742599Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others
Q39005896Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53.
Q33668830Tumorigenic WAP-T Mouse Mammary Carcinoma Cells: A Model for a Self-Reproducing Homeostatic Cancer Cell System
Q37802195Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies
Q38205099Unravelling mechanisms of p53-mediated tumour suppression
Q37832072p53 and its mutants in tumor cell migration and invasion

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