SOX2 oncogenes amplified and operate to activate AKT signaling in gastric cancer and predict immunotherapy responsiveness

scientific article published on 22 April 2014

SOX2 oncogenes amplified and operate to activate AKT signaling in gastric cancer and predict immunotherapy responsiveness is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

External links are
P356DOI10.1007/S00432-014-1660-0
P698PubMed publication ID24752338

P2093author name stringPeng Zhao
Yi Luo
Xin Jia
Junmin Wang
Yongsheng Li
Yajun Tian
Shengxiang Wang
Maosheng Dong
Da Cai
Zequan Zhou
P2860cites workSOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomasQ21562575
Structure of the extracellular region of HER2 alone and in complex with the Herceptin FabQ27640593
Lapatinib plus capecitabine for HER2-positive advanced breast cancerQ27851403
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trialQ27851578
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008Q27860674
New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of CanadaQ27860904
Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of RadiologyQ28271671
The distinctive nature of HER2-positive breast cancersQ28278028
Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimersQ28679173
Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the worldQ29614969
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomasQ30491937
Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cellsQ33518513
Sex determining region Y-Box 2 (SOX2) is a potential cell-lineage gene highly expressed in the pathogenesis of squamous cell carcinomas of the lungQ33531781
Breast cancer in the 21st century: neu opportunities and neu challengesQ34194240
Development of Herceptin resistance in breast cancer cellsQ34293506
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complexQ34314489
Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trialQ34634936
Sox2 Activates Cell Proliferation and Differentiation in the Respiratory EpitheliumQ35132159
Benefit of adjuvant chemotherapy for resectable gastric cancer: a meta-analysisQ37742318
Molecular mechanisms of cisplatin resistanceQ37926477
Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridizationQ38477505
Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin.Q40032261
Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer.Q40144433
Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cellsQ40321992
Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line.Q40461355
Rat Muc4 (sialomucin complex) reduces binding of anti-ErbB2 antibodies to tumor cell surfaces, a potential mechanism for herceptin resistanceQ40718678
Characteristics of cell lines established from human gastric carcinomaQ41735874
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.Q42823593
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growthQ44120544
HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.Q44450066
Sox transcription factors require selective interactions with Oct4 and specific transactivation functions to mediate reprogrammingQ47735041
Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).Q53985281
Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft modelsQ79218019
P433issue7
P921main subjectimmunotherapyQ1427096
P304page(s)1117-1124
P577publication date2014-04-22
P1433published inJournal of Cancer Research and Clinical OncologyQ2081599
P1476titleSOX2 oncogenes amplified and operate to activate AKT signaling in gastric cancer and predict immunotherapy responsiveness
P478volume140

Reverse relations

cites work (P2860)
Q90975867Association of High Expression Levels of SOX2, NANOG, and OCT4 in Gastric Cancer Tumor Tissues with Progression and Poor Prognosis
Q101403597CLC-3 and SOX2 regulate the cell cycle in DU145 cells
Q47317931Cancer Stem Cell Suppressing Activity of Chrysotoxine, a bibenzyl from Dendrobium pulchellum.
Q89427633Changing the natural history of metachronous gastric cancer after H. pylori eradication
Q38809827Cytoplasmic Drosha Is Aberrant in Precancerous Lesions of Gastric Carcinoma and Its Loss Predicts Worse Outcome for Gastric Cancer Patients
Q90046434Exosomal miR-1246 in serum as a potential biomarker for early diagnosis of gastric cancer
Q92086451High expression level of SOX2 is significantly associated with shorter survival in patients with thymic epithelial tumors
Q61443681Histone methyltransferase NSD2 regulates apoptosis and chemosensitivity in osteosarcoma
Q55295718Identification of hub genes with prognostic values in gastric cancer by bioinformatics analysis.
Q38352847Immunohistochemistry as a surrogate for molecular testing: a review.
Q59135024OCT4, SOX2, and NAN OG positive expression correlates with poor differentiation, advanced disease stages, and worse overall survival in HER2 + breast cancer patients
Q38239137SOX2 and cancer: current research and its implications in the clinic
Q53223422SOX2 expression in gastrointestinal cancers of Iranian patients.
Q43201485SOX2 expression is associated with FGFR fusion genes and predicts favorable outcome in lung squamous cell carcinomas
Q37376417SOX2 functions as a molecular rheostat to control the growth, tumorigenicity and drug responses of pancreatic ductal adenocarcinoma cells
Q36548775SOX2 suppresses CDKN1A to sustain growth of lung squamous cell carcinoma
Q38718397Sex-Determining Region Y-box 2 Promotes Growth of Lung Squamous Cell Carcinoma and Directly Targets Cyclin D1.
Q89279586TGF-β induces SOX2 expression in a time-dependent manner in human melanoma cells
Q38733504The dark side of SOX2: cancer - a comprehensive overview
Q36857674The prognostic value of whole blood SOX2, NANOG and OCT4 mRNA expression in advanced small-cell lung cancer
Q35113261Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer

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