Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes

scientific article published on 31 January 2002

Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M200102200
P698PubMed publication ID11823472

P2093author name stringThomas C Chiles
Cheryl Doughty
Michael J Piatelli
P2860cites workRole of tyrosine kinases in lymphocyte activationQ40626237
Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigenQ40822193
Analysis of site-specific phosphorylation of the retinoblastoma protein during cell cycle progression.Q40964495
Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phaseQ41093702
Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras AssociationQ41282697
p21-containing cyclin kinases exist in both active and inactive statesQ41451975
Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible systemQ41483751
Induction of cell cycle regulatory proteins in anti-immunoglobulin-stimulated mature B lymphocytesQ42122378
Multiple ras effector pathways contribute to G(1) cell cycle progressionQ42812883
Geldanamycin-induced destabilization of Raf-1 involves the proteasomeQ42834381
Vav is required for cyclin D2 induction and proliferation of mouse B lymphocytes activated via the antigen Receptor.Q44983668
Cyclin D1 provides a link between development and oncogenesis in the retina and breastQ52206604
Positive signaling through CD72 induces mitogen-activated protein kinase activation and synergizes with B cell receptor signals to induce X-linked immunodeficiency B cell proliferation.Q54001263
Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent PathwayQ57589068
BCR signals target p27Kip1 and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cellsQ59102114
Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell developmentQ59102116
Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinasesQ73316457
Bruton's tyrosine-kinase-deficient murine B lymphocytes fail to enter S phase when stimulated with anti-immunoglobulin plus interleukin-4Q74601268
Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.Q24529832
p50(cdc37) acting in concert with Hsp90 is required for Raf-1 functionQ24554532
Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)Q24685138
A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cellsQ24799869
Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agentQ27736012
CDK inhibitors: positive and negative regulators of G1-phase progressionQ27860983
Xid-like phenotypes: a B cell signalosome takes shapeQ28143004
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1Q28145116
The adaptor protein BLNK is required for b cell antigen receptor-induced activation of nuclear factor-kappa B and cell cycle entry and survival of B lymphocytesQ28207229
Cyclin D1 is a nuclear protein required for cell cycle progression in G1Q28269145
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localizationQ28290083
Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathwayQ28379145
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivoQ28609356
D-type cyclin-dependent kinase activity in mammalian cellsQ29614966
G1 phase progression: cycling on cueQ29615162
Identification of a novel inhibitor of mitogen-activated protein kinase kinaseQ29616448
Signal transduction from the B cell antigen-receptorQ33664755
Signal transduction pathways that regulate the fate of B lymphocytes.Q33683189
Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycleQ34076834
p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.Q34377527
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesionQ35107957
Early induction of cyclin D2 expression in phorbol ester-responsive B-1 lymphocytesQ36368254
Different protein tyrosine kinases are required for B cell antigen receptor-mediated activation of extracellular signal-regulated kinase, c-Jun NH2-terminal kinase 1, and p38 mitogen-activated protein kinase.Q36401603
Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1).Q38319947
Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expressionQ38489869
The regulated expression of cell cycle-related proteins as B-lymphocytes enter and progress through the G1 cell cycle stage following delivery of complete versus partial activation stimuliQ39114678
Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexesQ39574223
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectmolecular chaperonesQ422496
P304page(s)12144-12150
P577publication date2002-01-31
P1433published inJournal of Biological ChemistryQ867727
P1476titleRequirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes
P478volume277

Reverse relations

cites work (P2860)
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