Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists

scientific article published in February 2002

Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/JM0109614
P698PubMed publication ID11831890

P50authorBarbara CacciariQ114403516
Stefano MoroQ37828926
Karl-Norbert KlotzQ42882153
Giorgia PastorinQ47316874
Giampiero SpallutoQ92485723
P2093author name stringTatiana Da Ros
Pier Giovanni Baraldi
Katia Varani
Pier Andrea Borea
Stefania Gessi
P2860cites workHemodynamic effects and histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious ratsQ34871163
Molecular modeling studies of human A3 adenosine antagonists: structural homology and receptor dockingQ40989540
Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes.Q47829073
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)770-780
P577publication date2002-02-01
P1433published inJournal of Medicinal ChemistryQ900316
P1476titleSynthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists
P478volume45

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cites work (P2860)
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Q36342540Chapter 13. A3 Adenosine Receptors
Q34313641Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety
Q44554593Exploring the molecular basis of selectivity in A1 adenosine receptors agonists: a case study
Q28279556Highlights on the development of A(2A) adenosine receptor agonists and antagonists
Q59489014Ligand-, structure- and pharmacophore-based molecular fingerprints: a case study on adenosine A1, A2A, A2B, and A3 receptor antagonists
Q34490693Limits of ligand selectivity from docking to models: in silico screening for A(1) adenosine receptor antagonists
Q35545074Pyrazolo derivatives as potent adenosine receptor antagonists: an overview on the structure-activity relationships
Q37135506Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: A complete structure-activity profile
Q43049495Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: Effect of the N-5 bond type on the affinity and selectivity at the four adenosine receptor subtypes
Q36092094Quality Issues with Public Domain Chemogenomics Data.
Q40647461Recent developments in the field of A2A and A3 adenosine receptor antagonists
Q59171613Recent developments in the field of A3 adenosine receptor antagonists
Q28252689Structure-affinity relationships of adenosine A2B receptor ligands
Q46417110Synthesis and antimicrobial activity of some new pyrazole, fused pyrazolo[3,4-d]-pyrimidine and pyrazolo[4,3-e][1,2,4]-triazolo[1,5-c]pyrimidine derivatives
Q36626953Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility
Q35020369Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process
Q37957791The A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches
Q34313795The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors
Q37967933Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
Q35059150Use of the A(2A) adenosine receptor as a physiological immunosuppressor and to engineer inflammation in vivo

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