Recent developments in the field of A2A and A3 adenosine receptor antagonists

scientific article published on April 2003

Recent developments in the field of A2A and A3 adenosine receptor antagonists is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0223-5234(03)00042-4
P698PubMed publication ID12750024

P50authorDelia PretiQ56479662
P2093author name stringPier Giovanni Baraldi
Romeo Romagnoli
Katia Varani
Pier Andrea Borea
Mojgan Aghazadeh Tabrizi
Francesca Fruttarolo
Andrea Bovero
Barbara Avitabile
P2860cites workMolecular cloning and characterization of the human A3 adenosine receptorQ24564442
A physiological role of the adenosine A 3 receptor: Sustained cardioprotectionQ24650457
Crystal structure of rhodopsin: A G protein-coupled receptorQ27625972
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionQ27860958
7-Substituted 5-Amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2AAdenosine Receptor Antagonists: A Study on the Importance of Modifications at the Side Chain on the Activity and SolubilityQ28213414
Pharmacological and biochemical characterization of adenosine receptors in the human malignant melanoma A375 cell lineQ28363730
Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonistsQ28370203
Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptorsQ28372041
LIGAND: A versatile computerized approach for characterization of ligand-binding systemsQ29547346
8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor antagonists.Q32049468
A(2A) adenosine receptors in human peripheral blood cellsQ33849871
A(3) adenosine receptor ligands: history and perspectivesQ33866688
Neuroendocrine regulation of IL-12 and TNF-alpha/IL-10 balance. Clinical implicationsQ33939663
Structure and function of adenosine receptors and their genes.Q34101838
Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells.Q34156776
3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogsQ34169391
A3-adenosine receptors: design of selective ligands and therapeutic prospectsQ34204046
Blockade of adenosine A2A receptors by SCH 58261 results in neuroprotective effects in cerebral ischaemia in ratsQ34485914
Adenosine A3 receptors: novel ligands and paradoxical effectsQ35171034
The in vitro pharmacology of ZM 241385, a potent, non‐xanthine, A2a selective adenosine receptor antagonistQ35872902
Pharmacological and biochemical characterization of purified A2a adenosine receptors in human platelet membranes by [3H]-CGS 21680 bindingQ35873630
Adenosine A3 receptor stimulation and cerebral ischemiaQ36185246
8-(3-Chlorostyryl)caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivoQ36308893
Chronic administration of adenosine A3 receptor agonist and cerebral ischemia: neuronal and glial effectsQ36311423
Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonistQ40712319
Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studiesQ40787416
Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptorsQ40975392
Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtypeQ41158990
Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal gangliaQ41624006
3H‐SCH 58261 labelling of functional A2A adenosine receptors in human neutrophil membranesQ41961480
Binding of the radioligand [3H]-SCH 58261, a new non-xanthine A2A adenosine receptor antagonist, to rat striatal membranesQ42196443
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.Q42545166
A role for mast cells in adenosine A3 receptor‐mediated hypotension in the ratQ42708149
Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonistsQ42812168
Characterization of A2A adenosine receptors in human lymphocyte membranes by [3H]‐SCH 58261 bindingQ43176977
A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical studyQ43865622
Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonistsQ43879029
Binding thermodynamics at the human A(3) adenosine receptorQ43883966
(E)-1,3-Dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonistsQ46418896
Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes.Q47829073
Design, Synthesis, and Biological Evaluation of a Second Generation of Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as Potent and Selective A2A Adenosine Receptor AntagonistsQ47986048
Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeysQ48208543
Protection against kainate-induced excitotoxicity by adenosine A2A receptor agonists and antagonistsQ48458817
Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonistsQ48561677
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives: potent and selective A(2A) adenosine antagonistsQ49097634
Novel N6-(substituted-phenylcarbamoyl)adenosine-5'-uronamides as potent agonists for A3 adenosine receptorsQ49121544
Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Highly Potent and Selective Human A3Adenosine Receptor Antagonists: Influence of the Chain at the N8Pyrazole NitrogenQ56979856
Brain Adenosine Receptors as Targets for Therapeutic Intervention in Neurodegenerative DiseasesQ57405388
Adenosine A2A Antagonist: A novel antiparkinsonian agent that does not provoke dyskinesia in Parkinsonian monkeysQ64905504
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonistsQ73223426
4-Amino-6-benzylamino-1,2-dihydro-2-phenyl-1,2,4-triazolo [4,3-alpha]-quinoxalin-1-one: a new A2A adenosine receptor antagonist with high selectivity versus A1 receptorsQ77417378
A3 Adenosine Receptors: Protective vs. Damaging Effects Identified Using Novel Agonists and AntagonistsQ91750595
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)367-382
P577publication date2003-04-01
P1433published inEuropean Journal of Medicinal ChemistryQ3008624
P1476titleRecent developments in the field of A2A and A3 adenosine receptor antagonists
P478volume38

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cites work (P2860)
Q37358676Dual-target-directed drugs that block monoamine oxidase B and adenosine A(2A) receptors for Parkinson's disease
Q38395423History and perspectives of A2A adenosine receptor antagonists as potential therapeutic agents
Q59489014Ligand-, structure- and pharmacophore-based molecular fingerprints: a case study on adenosine A1, A2A, A2B, and A3 receptor antagonists
Q56990903Navigating in chromone chemical space: discovery of novel and distinct A3 adenosine receptor ligands
Q34306247Structure based prediction of subtype-selectivity for adenosine receptor antagonists