| scholarly article | Q13442814 |
| P50 | author | Laura P James | Q91702099 |
| Sandra S Mccullough | Q116289163 | ||
| P2093 | author name string | Philip R Mayeux | |
| Jack A Hinson | |||
| Howard P Hendrickson | |||
| Kenneth L Muldrew | |||
| Leslie Coop | |||
| P4510 | describes a project that uses | electrochemical detection | Q117822152 |
| high-performance liquid chromatography | Q381233 | ||
| P433 | issue | 4 | |
| P921 | main subject | high-performance liquid chromatography | Q381233 |
| hepatotoxicity | Q1349821 | ||
| paracetamol | Q57055 | ||
| P304 | page(s) | 446-451 | |
| P577 | publication date | 2002-04-01 | |
| P1433 | published in | Drug Metabolism and Disposition | Q1261140 |
| P1476 | title | Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection | |
| P478 | volume | 30 |
| Q35897795 | A Cytochrome P450-Independent Mechanism of Acetaminophen-Induced Injury in Cultured Mouse Hepatocytes |
| Q35966285 | Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure |
| Q92103604 | Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen |
| Q100519028 | Acetaminophen Toxicity: A History of Serendipity and Unintended Consequences |
| Q34997326 | Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia |
| Q44967726 | Acetaminophen hepatoxicity: what do we know, what don't we know, and what do we do next? |
| Q57455254 | Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways |
| Q36759456 | Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations. |
| Q37209814 | Acetaminophen protein adducts: a review |
| Q24624026 | Acetaminophen-associated hepatic injury: evaluation of acetaminophen protein adducts in children and adolescents with acetaminophen overdose |
| Q33845461 | Acetaminophen-cysteine adducts during therapeutic dosing and following overdose |
| Q35650720 | Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice |
| Q34715731 | Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase |
| Q37587843 | Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6. |
| Q38191681 | Acetaminophen-induced liver injury in obesity and nonalcoholic fatty liver disease |
| Q36339274 | Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. |
| Q51795776 | Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice. |
| Q44880248 | Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice |
| Q33792450 | Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice |
| Q35532037 | Acute liver failure after recommended doses of acetaminophen in patients with myopathies |
| Q37142641 | Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group |
| Q36054934 | Acute liver failure: Summary of a workshop |
| Q37512777 | Acylcarnitine profiles in acetaminophen toxicity in the mouse: comparison to toxicity, metabolism and hepatocyte regeneration |
| Q38958100 | An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure |
| Q101381134 | Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen |
| Q46269173 | Biochemical targets of drugs mitigating oxidative stress via redox-independent mechanisms |
| Q57163738 | Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation |
| Q51369690 | Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury. |
| Q28546783 | Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity |
| Q91649544 | Comparison of toxic responses to acetaminophen challenge in ICR mice originating from different sources |
| Q49081603 | Connexin hemichannel inhibition reduces acetaminophen-induced liver injury in mice |
| Q37136563 | Connexin32: a mediator of acetaminophen-induced liver injury? |
| Q38979533 | Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures. |
| Q34792136 | Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products |
| Q41080871 | Detection of Acetaminophen-Protein Adducts in Decedents with Suspected Opioid-Acetaminophen Combination Product Overdose |
| Q51367970 | Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J. |
| Q46478721 | Dose- and time-dependent oval cell reaction in acetaminophen-induced murine liver injury. |
| Q49864463 | EXTRAHEPATIC TOXICITY OF ACETAMINOPHEN: CRITICAL EVALUATION OF THE EVIDENCE AND PROPOSED MECHANISMS. |
| Q35788415 | Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice |
| Q36458962 | Effect of trifluoperazine on toxicity, HIF-1α induction and hepatocyte regeneration in acetaminophen toxicity in mice |
| Q38958076 | Essential role of protein-tyrosine phosphatase 1B in the modulation of insulin signaling by acetaminophen in hepatocytes |
| Q64980282 | Extrahepatic toxicity of acetaminophen: critical evaluation of the evidence and proposed mechanisms. |
| Q36988910 | Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress |
| Q40198195 | Gab1 adaptor protein acts as a gatekeeper to balance hepatocyte death and proliferation during acetaminophen-induced liver injury in mice |
| Q36642297 | Glycocapture-assisted global quantitative proteomics (gagQP) reveals multiorgan responses in serum toxicoproteome |
| Q37083592 | Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study |
| Q34775607 | HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity |
| Q33556839 | Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury |
| Q34028172 | Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity |
| Q39540923 | Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice. |
| Q47287461 | In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI. |
| Q34611529 | Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity |
| Q43701391 | Influence of acetaminophen at therapeutic doses on surrogate markers of severity of acute viral hepatitis. |
| Q36186396 | Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity |
| Q33632064 | Involvement of connexin43 in acetaminophen-induced liver injury. |
| Q35969312 | Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury |
| Q35185719 | Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase. |
| Q34225946 | Mechanisms of acetaminophen-induced cell death in primary human hepatocytes. |
| Q24629891 | Mechanisms of acetaminophen-induced liver necrosis |
| Q38212434 | Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients |
| Q37638755 | Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective |
| Q42364556 | MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity |
| Q54205999 | Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. |
| Q36718265 | Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products. |
| Q36688003 | Nasal cytotoxic and carcinogenic activities of systemically distributed organic chemicals |
| Q37656707 | Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity |
| Q36618136 | Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing |
| Q44118518 | Paracetamol poisoning in the UK: a meeting report from Pharmacology 2013. |
| Q92855818 | Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration |
| Q57724827 | Pathophysiological Relevance of Proteomics Investigations of Drug-Induced Hepatotoxicity in HepG2 Cells |
| Q37266295 | Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure |
| Q36844150 | Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications. |
| Q34993617 | Pleurotus ostreatus opposes mitochondrial dysfunction and oxidative stress in acetaminophen-induced hepato-renal injury |
| Q36022680 | Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children |
| Q37612408 | Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning |
| Q47288375 | Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. |
| Q36907101 | Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity. |
| Q36509045 | Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation |
| Q37216910 | Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice |
| Q35861532 | Retinoid regulation of antiviral innate immunity in hepatocytes. |
| Q36879950 | Role of the Nrf2-ARE pathway in liver diseases |
| Q35589761 | Separation and detection methods for covalent drug-protein adducts |
| Q55192083 | Simple reversed-phase HPLC method with spectrophotometric detection for measuring acetaminophen-protein adducts in rat liver samples. |
| Q35080126 | Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice |
| Q36072453 | Target biomarker profile for the clinical management of paracetamol overdose |
| Q34015035 | Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children |
| Q41679331 | Targeted metabolomic profiling indicates structure-based perturbations in serum phospholipids in children with acetaminophen overdose |
| Q37381548 | The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation |
| Q35858082 | The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation |
| Q37234535 | The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes. |
| Q48707645 | The pharmacokinetics of a single rectal dose of paracetamol (40 mg x kg(-1)) in children with liver disease |
| Q35572609 | The proper use of acetaminophen |
| Q42704352 | The role of intrahepatic CD3+/CD4-/CD8- double negative T (DN T) cells in enhanced acetaminophen toxicity |
| Q36005892 | Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells. |
| Q36001451 | Translational biomarkers of acetaminophen-induced acute liver injury |
| Q38786694 | Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes. |
| Q35529749 | Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure |
| Q37062652 | What factors determine the severity of hepatitis A-related acute liver failure? |
| Q42516008 | miRNA-122 Protects Mice and Human Hepatocytes from Acetaminophen Toxicity by Regulating Cytochrome P450 Family 2 Subfamily A Member 2 and E Member 1 Expression |
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