Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity.

scientific article

Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00204-016-1692-0
P932PMC publication ID5033665
P698PubMed publication ID27002509
P5875ResearchGate publication ID299343028

P50authorHartmut JaeschkeQ88437804
P2093author name stringKuo Du
Anwar Farhood
P2860cites workPathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicityQ26799194
AASLD position paper: the management of acute liver failureQ28246028
A direct comparison of methods used to measure oxidized glutathione in biological samples: 2-vinylpyridine and N-ethylmaleimideQ28834681
c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicityQ33912798
Therapeutic targeting of mitochondrial superoxide in hypertensionQ33981734
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)Q34048790
The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytesQ34131871
Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.Q34225946
Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteineQ34277808
Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteineQ34294926
Targeting mitochondria-derived reactive oxygen species to reduce epithelial barrier dysfunction and colitis.Q34299931
The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicityQ34630779
Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutaseQ34715731
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicityQ35161427
Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.Q35185719
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentationQ35858082
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injuryQ35969312
Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells.Q36005892
Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher dosesQ36404920
Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.Q36844150
Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injuryQ37506627
Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injuryQ37655972
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicityQ37656707
Molecular mechanisms of the hepatotoxicity caused by acetaminophenQ38027602
Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patientsQ38212434
Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injuryQ38291198
Selective protein covalent binding and target organ toxicityQ41387154
Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in miceQ41495452
Lipopolysaccharide-induced mitochondrial DNA depletionQ42730490
Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stressQ43673027
Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detectionQ43921972
Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?Q43994104
Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathioneQ44186021
Characterization of acetaminophen overdose-related emergency department visits and hospitalizations in the United States.Q44492403
Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formationQ44527209
Acetaminophen overdose-induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D-regulated permeability transitionQ44680186
Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytesQ45108825
Use of isolated perfused organs in hypoxia and ischemia/reperfusion oxidant stressQ45136664
Emergency department visits for overdoses of acetaminophen-containing productsQ45706009
Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophenQ46068587
Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicityQ46635865
A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondriaQ46800001
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicityQ46974191
Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in miceQ47978001
Acetaminophen-induced inhibition of hepatic mitochondrial respiration in miceQ68355910
Early loss of large genomic DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen-induced liver injuryQ68628042
Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinolQ68637975
Acetaminophen overdoseQ70305728
Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicityQ72411992
Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8Q73128535
Inhibition of Fas receptor (CD95)-induced hepatic caspase activation and apoptosis by acetaminophen in miceQ77381301
Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injuryQ80077527
Acetaminophen hepatotoxicityQ80853377
P433issue2
P921main subjectmitochondrionQ39572
paracetamolQ57055
hepatotoxicityQ1349821
P304page(s)761-773
P577publication date2016-03-22
P1433published inArchives of ToxicologyQ635837
P1476titleMitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity
P478volume91

Reverse relations

cites work (P2860)
Q90627832A mitochondrial journey through acetaminophen hepatotoxicity
Q92231738Acetaminophen Hepatotoxicity
Q47885559Acetaminophen Toxicity Novel Insights into Mechanisms and Future Perspectives
Q92862541Allium Jesdianum Extract Improve Acetaminophen-Induced Hepatic Failure through Inhibition of Oxidative/Nitrosative Stress
Q90097440Animal models of drug-induced liver injury
Q104694481Assessment of the Biochemical Pathways for Acetaminophen Toxicity: Implications for its Carcinogenic Hazard Potential
Q46269173Biochemical targets of drugs mitigating oxidative stress via redox-independent mechanisms
Q91596768Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose
Q60912532Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway
Q92999694Ctt1 catalase activity potentiates antifungal azoles in the emerging opportunistic pathogen Saccharomyces cerevisiae
Q96953977Does JNK Regulate Acetaminophen Hepatotoxicity by Modulating Nrf2-dependent Genes or Mitochondrial Oxidant Stress?
Q39452662Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
Q92213570Emerging novel therapies against paracetamol (acetaminophen) hepatotoxicity
Q64298462Highlight report: Role of the ATP-releasing Panx channels in liver fibrosis
Q47796568Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity
Q93053142Inhibition of Mitochondrial ROS by MitoQ Alleviates White Matter Injury and Improves Outcomes after Intracerebral Haemorrhage in Mice
Q90618229Late Protective Effect of Netrin-1 in the Murine Acetaminophen Hepatotoxicity Model
Q52599702Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity.
Q90600105Mechanisms of Inflammatory Liver Injury and Drug-Induced Hepatotoxicity
Q33848167Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology
Q55407513Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions.
Q57461348Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity
Q97525891Mitochondrial Damage and Biogenesis in Acetaminophen-induced Liver Injury
Q92377698Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives
Q55092510Mitochondrial-Lysosomal Axis in Acetaminophen Hepatotoxicity.
Q93129152NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries
Q45932834New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases.
Q94023832Oxidant Stress and Lipid Peroxidation in Acetaminophen Hepatotoxicity
Q87686282Oxidative Stress and Acute Hepatic Injury
Q28077959Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential
Q60948762Parathyroid Hormone Causes Endothelial Dysfunction by Inducing Mitochondrial ROS and Specific Oxidative Signal Transduction Modifications
Q90214018TGF-β/SMAD4 mediated UCP2 downregulation contributes to Aspergillus protease-induced inflammation in primary bronchial epithelial cells
Q89487254Targeting Evolutionary Conserved Oxidative Stress and Immunometabolic Pathways for the Treatment of Respiratory Infectious Diseases
Q41347692Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: Implications for optimizing anti-angiogenic therapy
Q92705157Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress
Q88083201Treatment of acetaminophen-induced liver injury with exogenous mitochondria in mice
Q42516008miRNA-122 Protects Mice and Human Hepatocytes from Acetaminophen Toxicity by Regulating Cytochrome P450 Family 2 Subfamily A Member 2 and E Member 1 Expression

Search more.