| scholarly article | Q13442814 |
| P2093 | author name string | Hartmut Jaeschke | |
| Anup Ramachandran | |||
| Nga Nguyen | |||
| Luqi Duan | |||
| P2860 | cites work | Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury | Q80077527 |
| AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver | Q84853674 | ||
| Drug-induced acute liver failure | Q86481862 | ||
| Role and mechanisms of autophagy in acetaminophen-induced liver injury | Q88437809 | ||
| The role of apoptosis in acetaminophen hepatotoxicity | Q89151907 | ||
| Acetaminophen hepatotoxicity: A mitochondrial perspective | Q91896642 | ||
| Evaluation and treatment of acetaminophen toxicity | Q91896663 | ||
| Principal results of a randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with a 12 h regimen of N-acetylcysteine for paracetamol overdose (POP trial) | Q91934497 | ||
| Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase | Q92565456 | ||
| Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. | Q24533236 | ||
| Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity | Q26799194 | ||
| Regulation of mitochondrial biogenesis and its intersection with inflammatory responses | Q26851729 | ||
| Transcriptional integration of mitochondrial biogenesis | Q26998468 | ||
| Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation | Q27681368 | ||
| The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study | Q28211832 | ||
| Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice | Q29619811 | ||
| c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. | Q30009024 | ||
| c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice | Q30010257 | ||
| Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. | Q33707120 | ||
| Acetaminophen-cysteine adducts during therapeutic dosing and following overdose | Q33845461 | ||
| c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity | Q33912798 | ||
| A randomized, placebo-controlled trial to determine the course of aminotransferase elevation during prolonged acetaminophen administration | Q33987828 | ||
| Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985) | Q34048790 | ||
| Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes. | Q34071991 | ||
| Regulation of mitochondrial biogenesis | Q34119796 | ||
| The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes | Q34131871 | ||
| Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione | Q34218007 | ||
| Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine | Q34294926 | ||
| The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity | Q34630779 | ||
| Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase | Q34715731 | ||
| HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity | Q34775607 | ||
| Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity | Q35161427 | ||
| Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury | Q35648831 | ||
| Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells. | Q36005892 | ||
| Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes | Q36296762 | ||
| Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity | Q36335609 | ||
| Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. | Q36339274 | ||
| Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury | Q36418502 | ||
| Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing | Q36618136 | ||
| Can paracetamol (acetaminophen) be administered to patients with liver impairment? | Q36802077 | ||
| Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications. | Q36844150 | ||
| Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis | Q37004604 | ||
| Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver | Q37272644 | ||
| Acetaminophen and acetylcysteine dose and duration: past, present and future. | Q37982762 | ||
| Calmangafodipir [Ca4Mn(DPDP)5], mangafodipir (MnDPDP) and MnPLED with special reference to their SOD mimetic and therapeutic properties | Q38281036 | ||
| Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury | Q38291198 | ||
| Regulation of mitochondrial biogenesis through TFAM-mitochondrial DNA interactions: Useful insights from aging and calorie restriction studies. | Q38599393 | ||
| Translocation of iron from lysosomes to mitochondria during acetaminophen-induced hepatocellular injury: Protection by starch-desferal and minocycline | Q41247629 | ||
| Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure | Q41396770 | ||
| Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice | Q41495452 | ||
| The role of MAP2 kinases and p38 kinase in acute murine liver injury models | Q41614993 | ||
| Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice | Q42644118 | ||
| DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. | Q43540280 | ||
| Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2. | Q43771481 | ||
| Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry | Q43838611 | ||
| Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation | Q44163069 | ||
| Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione | Q44186021 | ||
| Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation | Q44527209 | ||
| Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice | Q44566093 | ||
| Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: roles of cytochrome c, Bax, Bid, and caspases | Q44567499 | ||
| Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice | Q44572957 | ||
| Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine | Q44872545 | ||
| Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes | Q45108825 | ||
| Retention of oxidized glutathione by isolated rat liver mitochondria during hydroperoxide treatment | Q45168273 | ||
| Hepatic protein arylation, glutathione depletion, and metabolite profiles of acetaminophen and a non-hepatotoxic regioisomer, 3'-hydroxyacetanilide, in the mouse | Q45233835 | ||
| Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen | Q46068587 | ||
| How to protect against acetaminophen: don't ask for JUNK. | Q46377406 | ||
| Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity | Q46635865 | ||
| c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity | Q46679597 | ||
| Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice | Q46924515 | ||
| Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity | Q46974191 | ||
| Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity | Q47796568 | ||
| Reversal of bioenergetics dysfunction by diphenyl diselenide is critical to protection against the acetaminophen-induced acute liver failure. | Q47892773 | ||
| Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo | Q47953556 | ||
| Nitrotyrosine-protein adducts in hepatic centrilobular areas following toxic doses of acetaminophen in mice | Q47978001 | ||
| Sestrin2 facilitates glutamine dependent transcription of PGC-1α and survival of liver cancer cells under glucose limitation | Q50049604 | ||
| Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury | Q50222849 | ||
| Non-cytotoxic concentrations of acetaminophen induced mitochondrial biogenesis and antioxidant response in HepG2 cells. | Q51486591 | ||
| Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. | Q52533533 | ||
| Potential adjunct treatment for high-risk acetaminophen overdose. | Q53163271 | ||
| Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. | Q54205999 | ||
| 4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes. | Q54979538 | ||
| Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity | Q57461348 | ||
| Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol | Q68637975 | ||
| Acetaminophen-induced oxidation of protein thiols. Contribution of impaired thiol-metabolizing enzymes and the breakdown of adenine nucleotides | Q68708733 | ||
| Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide, in mouse liver | Q69302284 | ||
| Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice | Q69551410 | ||
| Effect of acetaminophen on hepatic content and biliary efflux of glutathione disulfide in mice | Q69648886 | ||
| Drug-induced lipid peroxidation in mice—I Modulation by monooxegenase activity, glutathione and selenium status | Q70996572 | ||
| Aminotransferase activities in healthy subjects receiving three-day dosing of 4, 6, or 8 grams per day of acetaminophen | Q79936378 | ||
| Disposition of acetaminophen at 4, 6, and 8 g/day for 3 days in healthy young adults | Q80008253 | ||
| P433 | issue | 3-4 | |
| P304 | page(s) | 150-156 | |
| P577 | publication date | 2019-11-01 | |
| P1433 | published in | Liver Research | Q96319940 |
| P1476 | title | Mitochondrial Damage and Biogenesis in Acetaminophen-induced Liver Injury | |
| P478 | volume | 3 |
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