New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases.

scientific article published on 30 November 2017

New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/HEP.29689
P8608Fatcat IDrelease_x4h7vkacgjarjjhg7fixjptfsa
P932PMC publication ID5906137
P698PubMed publication ID29194686

P50authorSanda WinQ89453719
P2093author name stringJun Zhang
Neil Kaplowitz
Tin Aung Than
Christina Oo
Robert Win Maw Min
P2860cites workFGF-21 as a novel metabolic regulatorQ24523933
A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondriaQ24534841
Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injuryQ38291198
Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytesQ38594016
Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytesQ38603408
Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis.Q38627620
Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.Q38700457
Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicityQ38911401
Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosisQ39731721
Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular CarcinomaQ40011787
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer DevelopmentQ40045418
JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell deathQ40138480
Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates.Q40327138
The role of MAP2 kinases and p38 kinase in acute murine liver injury modelsQ41614993
Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1.Q41749934
A stress signaling pathway in adipose tissue regulates hepatic insulin resistanceQ41811449
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activationQ44163069
Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria.Q45933968
Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factorQ46254405
c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicityQ46679597
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.Q46808839
Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in miceQ46924515
A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic.Q50488654
TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.Q53299056
Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity.Q54205999
The JNK signal transduction pathwayQ79781771
Free fatty acids induce JNK-dependent hepatocyte lipoapoptosisQ82677113
Mechanisms of Acetaminophen Hepatotoxicity: Do We Need JNK for Cell Death?Q87813408
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation responseQ24653481
Role of endoplasmic reticulum stress in drug-induced toxicityQ26765518
Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicityQ26799194
Signal transduction by the JNK group of MAP kinasesQ28142592
Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1Q28207670
Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatasesQ28239642
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesityQ28256254
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approachesQ28392033
A central role for JNK in obesity and insulin resistanceQ29619778
c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src.Q30009024
c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in miceQ30010257
c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicityQ33912798
Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in miceQ34117033
The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathwayQ34143232
cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistanceQ34285542
JNK regulation of hepatic manifestations of the metabolic syndromeQ34348797
Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesityQ34364833
Mitochondrial c-Jun N-terminal kinase (JNK) signaling initiates physiological changes resulting in amplification of reactive oxygen species generation.Q34963377
The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injuryQ35642533
Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injuryQ35648831
Improvement of liver injury and survival by JNK2 and iNOS deficiency in liver transplants from cardiac death miceQ35763021
Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activationQ35808753
Metabolic stress signaling mediated by mixed-lineage kinasesQ36002831
Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicityQ36335609
Blocking c-Jun N-terminal kinase (JNK) translocation to the mitochondria prevents 6-hydroxydopamine-induced toxicity in vitro and in vivo.Q36526237
Inhibition of JNK mitochondrial localization and signaling is protective against ischemia/reperfusion injury in ratsQ36596206
Bile-acid-induced cell injury and protectionQ37157813
FGF21 regulates metabolism and circadian behavior by acting on the nervous systemQ37161082
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammationQ37330051
MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched dietQ37476440
Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury.Q37617674
The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocationQ37822076
Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondriaQ38085856
The novel intracellular protein CREG inhibits hepatic steatosis, obesity, and insulin resistanceQ38288136
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)2013-2024
P577publication date2018-04-06
P1433published inHepatologyQ15724398
P1476titleNew insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases
P478volume67

Reverse relations

cites work (P2860)
Q93038072ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model
Q55365441Bavachinin Induces Oxidative Damage in HepaRG Cells through p38/JNK MAPK Pathways.
Q64108612Combined effects of ambient particulate matter exposure and a high-fat diet on oxidative stress and steatohepatitis in mice
Q90226091Elevated SH3BP5 Correlates with Poor Outcome and Contributes to the Growth of Acute Myeloid Leukemia Cells
Q93122181Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury
Q64973345Fibroblast growth factors 19 and 21 in acute liver damage.
Q92243745Hepatoprotective Effect of Jianpi Huoxue Formula on Nonalcoholic Fatty Liver Disease Induced by Methionine-Choline-Deficient Diet in Rat
Q91302357Mannan-binding lectin attenuates acetaminophen-induced hepatotoxicity by regulating CYP2E1 expression via ROS-dependent JNK/SP1 pathway
Q90382152Mitogen-Activated Protein Kinases (MAPKs) and Cholangiocarcinoma: The Missing Link
Q98613138Oxidative stress in alcohol-related liver disease
Q91892215SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition
Q95856699The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury
Q59792854The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects
Q89747950trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop

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