| scholarly article | Q13442814 |
| review article | Q7318358 |
| P356 | DOI | 10.1055/S-2008-1040482 |
| P698 | PubMed publication ID | 2281334 |
| P2093 | author name string | S D Nelson | |
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | hepatotoxicity | Q1349821 |
| P304 | page(s) | 267-278 | |
| P577 | publication date | 1990-11-01 | |
| P1433 | published in | Seminars in Liver Disease | Q15724477 |
| P1476 | title | Molecular mechanisms of the hepatotoxicity caused by acetaminophen | |
| P478 | volume | 10 |
| Q64777625 | Q64777625 |
| Q54979538 | 4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes. |
| Q38962365 | A systematic assessment of mitochondrial function identified novel signatures for drug-induced mitochondrial disruption in cells |
| Q77716553 | Acarbose alone or in combination with ethanol potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen in rats |
| Q34303815 | Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: Analysis of instances of therapeutic misadventure |
| Q47885559 | Acetaminophen Toxicity Novel Insights into Mechanisms and Future Perspectives |
| Q24311331 | Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes |
| Q42453507 | Acetaminophen hepatotoxicity in tumor necrosis factor/lymphotoxin-alpha gene knockout mice |
| Q73375437 | Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: protection by triacetyloleandomycin |
| Q43979608 | Acetaminophen hepatotoxicity: the first 35 years |
| Q24791077 | Acetaminophen toxicity: suicidal vs. accidental |
| Q34781465 | Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice |
| Q36339274 | Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. |
| Q51795776 | Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice. |
| Q42975692 | Acute ANIT toxicity in male IL-10 knockout and wild-type mice |
| Q24524192 | Adverse drug reactions |
| Q24652340 | Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice |
| Q50711336 | Ameliorative Effects and Possible Molecular Mechanism of Action of Black Ginseng (Panax ginseng) on Acetaminophen-Mediated Liver Injury. |
| Q60054002 | An imazamox-based herbicide causes apoptotic changes in rat liver and pancreas |
| Q36382247 | Apoptosis and necrosis in the liver: a tale of two deaths? |
| Q35161427 | Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity |
| Q44581878 | Autoprotection against acetaminophen toxicity in cultured rat hepatocytes: the effect of pretreatment and growth factors |
| Q47875295 | Benzyl alcohol attenuates acetaminophen-induced acute liver injury in a Toll-like receptor-4-dependent pattern in mice |
| Q36404920 | Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses |
| Q38954228 | Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells |
| Q36335609 | Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity |
| Q36803099 | Curcumin improves liver damage in male mice exposed to nicotine |
| Q34792136 | Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products |
| Q37506627 | Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury |
| Q51367970 | Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J. |
| Q64233306 | Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice |
| Q36835826 | Drug metabolite profiling and elucidation of drug-induced hepatotoxicity |
| Q39452662 | Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction. |
| Q42720360 | Effect of Asparagus falcatus on acetaminophen toxicity in mice: a comparison of antioxidative effect with N-acetyl cysteine |
| Q46899603 | Effect of platelet-activating factor (PAF) receptor antagonist (BN52021) on acetaminophen-induced acute liver injury and regeneration in rats |
| Q43072129 | Effects of medical ozone therapy on acetaminophen-induced nephrotoxicity in rats |
| Q36221425 | Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury |
| Q64976206 | Enhanced autophagy contributes to protective effects of IL-22 against acetaminophen-induced liver injury. |
| Q23911056 | Ethanol-mediated CYP1A1/2 induction in rat skeletal muscle tissue |
| Q43109563 | Evaluation of nephroprotective, diuretic, and antioxidant activities of plectranthus amboinicus on acetaminophen-induced nephrotoxic rats |
| Q42552983 | Expression of liver-specific functions in rat hepatocytes following sublethal and lethal acetaminophen poisoning |
| Q36988910 | Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress |
| Q38268600 | Formation of reactive metabolites and management of tyrosine kinase inhibitor-induced hepatotoxicity: a literature review |
| Q35184553 | Fulminant liver disease |
| Q37698409 | Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity |
| Q41297402 | Glutathione peroxidase 3 is a protective factor against acetaminophen‑induced hepatotoxicity in vivo and in vitro |
| Q90336682 | Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy |
| Q46676928 | Green-tea polyphenols downregulate cyclooxygenase and Bcl-2 activity in acetaminophen-induced hepatotoxicity |
| Q34775607 | HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity |
| Q37771144 | Hepatic drug-metabolizing enzyme induction and implications for preclinical and clinical risk assessment |
| Q35434815 | Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice |
| Q41884113 | Hepatoprotective Effect of Pretreatment with Thymus vulgaris Essential Oil in Experimental Model of Acetaminophen-Induced Injury |
| Q47792378 | Hepatoprotective effect of the fractions of Ban-zhi-lian on experimental liver injuries in rats |
| Q99239256 | Hepatoprotective effects of Gamisoyo-san against acetaminophen-induced liver injuries |
| Q52791870 | Hepatotoxicity Induced by Subchronic Exposure of Fluoride and Chlorpyrifos in Wistar Rats: Mitigating Effect of Ascorbic Acid. |
| Q77142017 | Hepatotoxicity of non-narcotic analgesics |
| Q34262481 | High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity |
| Q55313873 | High-Mobility Group Box 1-Induced Complement Activation Causes Sterile Inflammation. |
| Q34429206 | Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors |
| Q32058433 | Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry |
| Q41172369 | Idiosyncratic drug reactions. Metabolic bioactivation as a pathogenic mechanism |
| Q36249424 | In vitro assessment of hepatoprotective agents against damage induced by acetaminophen and CCl4. |
| Q73047665 | Influence of polymorphic N-acetyltransferase phenotype on the inhibition and induction of acetaminophen bioactivation with long-term isoniazid |
| Q90565887 | Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone |
| Q64230062 | Inhibition of mitochondrial complex I by rotenone protects against acetaminophen-induced liver injury |
| Q46408094 | Innate immunity and acetaminophen-induced liver injury: why so many controversies? |
| Q92117313 | Integration of in vitro data from three dimensionally cultured HepaRG cells and physiologically based pharmacokinetic modeling for assessment of acetaminophen hepatotoxicity |
| Q36263962 | Intracellular signaling mechanisms of acetaminophen-induced liver cell death |
| Q36412669 | Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity |
| Q92377489 | Lack of direct cytotoxicity of extracellular ATP against hepatocytes: role in the mechanism of acetaminophen hepatotoxicity |
| Q90618229 | Late Protective Effect of Netrin-1 in the Murine Acetaminophen Hepatotoxicity Model |
| Q70585931 | Liver failure induced by paracetamol |
| Q28327668 | Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure |
| Q35185719 | Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase. |
| Q34071991 | Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes. |
| Q47111246 | Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse |
| Q37463698 | Mechanism of protection by metallothionein against acetaminophen hepatotoxicity |
| Q57302639 | Mechanisms of Adverse Drug Reactions |
| Q33848167 | Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology |
| Q34169362 | Mechanisms of drug-induced liver injury: from bedside to bench |
| Q40463530 | Mechanisms of the Formation and Disposition of Reactive Metabolites That can Cause Acute Liver Injury |
| Q38212434 | Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients |
| Q81121304 | Metabolomic applications of electrochemistry/mass spectrometry |
| Q57461348 | Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity |
| Q54205999 | Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. |
| Q33649876 | Mitochondrial glutathione, a key survival antioxidant |
| Q36648759 | Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: effect on HMG-CoA synthase |
| Q36418502 | Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury |
| Q36718265 | Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products. |
| Q73412581 | Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform |
| Q35581234 | Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation. |
| Q38994159 | Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans. |
| Q47404871 | Natural polyphenol chlorogenic acid protects against acetaminophen-induced hepatotoxicity by activating ERK/Nrf2 antioxidative pathway |
| Q39445350 | Non-NSAID pharmacologic treatment options for the management of chronic pain |
| Q35796961 | Non-Steroid Anti-Inflammatory Drugs Are Better than Acetaminophen on Fever Control at Acute Stage of Fracture |
| Q92377619 | Novel circulating- and imaging-based biomarkers to enhance the mechanistic understanding of human drug-induced liver injury |
| Q34294926 | Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine |
| Q37407996 | Outcomes of patients with acetaminophen-associated toxic hepatitis at a far east poison center |
| Q57724827 | Pathophysiological Relevance of Proteomics Investigations of Drug-Induced Hepatotoxicity in HepG2 Cells |
| Q36697050 | Peroxynitrite formation and sinusoidal endothelial cell injury during acetaminophen-induced hepatotoxicity in mice |
| Q39945377 | Phenotypic and biomarker evaluation of zebrafish larvae as an alternative model to predict mammalian hepatotoxicity |
| Q37324704 | Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose |
| Q46952527 | Platelet activating factor (PAF) antagonism with ginkgolide B protects the liver against acute injury. importance of controlling the receptor of PAF. |
| Q80101971 | Platelet-activating factor inactivator (rPAF-AH) enhances liver's recovery after paracetamol intoxication |
| Q43853507 | Potentiation of the immunotoxicity of ethanol by acetaminophen in mice |
| Q35342293 | Preventive Effect of the Korean Traditional Health Drink (Taemyeongcheong) on Acetaminophen-Induced Hepatic Damage in ICR Mice |
| Q37210142 | Prolonged treatment with N-acetylcystine delays liver recovery from acetaminophen hepatotoxicity |
| Q44648370 | Protective effect of Asteracantha longifolia extract in mouse liver injury induced by carbon tetrachloride and paracetamol |
| Q35938391 | Protective effect of chlormethiazole, a sedative, against acetaminophen-induced liver injury in mice |
| Q42479201 | Protective effect of ethanol against acetaminophen-induced hepatotoxicity in mice: role of NADH:quinone reductase |
| Q35033821 | Protective effects of 2,4-dihydroxybenzophenone against acetaminophen-induced hepatotoxicity in mice |
| Q85848419 | Protective effects of BML-111 against acetaminophen-induced acute liver injury in mice |
| Q36509045 | Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation |
| Q41895629 | Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues |
| Q79424116 | Recombinant platelet-activating factor-acetylhydrolase attenuates paracetamol-induced liver oxidative stress, injury, and regeneration |
| Q36747725 | Redox Nanoparticle Therapeutics for Acetaminophen-Induced Hepatotoxicity in Mice |
| Q33830140 | Redox control of liver function in health and disease |
| Q59273487 | Reduction of Acute Hepatic Damage Induced by Acetaminophen after Treatment with Diphenyl Diselenide in Mice |
| Q39790357 | Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice |
| Q34756497 | Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: an explanation for high acetaminophen dosage in humans without hepatic injury |
| Q34074958 | Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity |
| Q88437809 | Role and mechanisms of autophagy in acetaminophen-induced liver injury |
| Q34088397 | Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury |
| Q41983643 | Role of free radicals in liver diseases. |
| Q34909256 | Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury |
| Q28507729 | SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity |
| Q61811661 | SOCS2 Is Critical for the Balancing of Immune Response and Oxidate Stress Protecting Against Acetaminophen-Induced Acute Liver Injury |
| Q35102625 | Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration. |
| Q64998988 | Selective Extraction and Antioxidant Properties of Thiol-Containing Peptides in Soy Glycinine Hydrolysates. |
| Q92767348 | Spatial heterogeneity in the mammalian liver |
| Q70150663 | Subliminal drug-drug interactions: users and their physicians take notice |
| Q46420043 | Synergistic action of sodium selenite and N-acetylcysteine in acetaminophen-induced liver damage. |
| Q34569481 | The Effect of Chronic Alcohol Intake on Prognosis and Outcome in Paracetamol Overdose |
| Q57821245 | The Role of Acetyl Cysteine in Cocaethylene (Non-Acetaminophen) Acute Liver Failure |
| Q56474940 | The Role of Active Metabolites in Drug Toxicity |
| Q85571659 | The antiinflammatory and liver protective effects of Boehmeria nivea and B. nivea subsp. nippononivea in rats |
| Q28211832 | The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study |
| Q73562528 | The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin |
| Q46224668 | The effects of acute acetaminophen toxicity on hepatic mRNA expression of SOD, CAT, GSH-Px, and levels of peroxynitrite, nitric oxide, reduced glutathione, and malondialdehyde in rabbit |
| Q37381548 | The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation |
| Q33760064 | The hepatic stem cell niche: identification by label-retaining cell assay |
| Q73741792 | The hepatoprotective effects of Solanum alatum Moench. on acetaminophen-induced hepatotoxicity in mice |
| Q34630779 | The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity |
| Q35858082 | The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation |
| Q41401684 | The metabolism of psychoactive drugs: a review of enzymatic biotransformation and inhibition |
| Q34131871 | The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes |
| Q42704179 | The protective role of NAD(P)H:quinone oxidoreductase 1 on acetaminophen-induced liver injury is associated with prevention of adenosine triphosphate depletion and improvement of mitochondrial dysfunction |
| Q33653566 | The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice |
| Q41656963 | The role of reactive drug metabolites in immune-mediated adverse drug reactions |
| Q60932222 | Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver Injury |
| Q84080339 | This article has been retracted: Safety pharmacology, acute toxicity and pharmacokinetics of SCP-123 and acetaminophen |
| Q53668234 | Toxicity of hepatotoxins: new insights into mechanisms and therapy. |
| Q44026686 | Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats |
| Q34525342 | Tumor induced hepatic myeloid derived suppressor cells can cause moderate liver damage |
| Q39671998 | Unexplained metabolic acidosis in critically ill patients: the role of pyroglutamic acid |
| Q34109283 | Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects |
| Q45977657 | Yang-Gan-Wan protects mice against experimental liver damage. |
| Q79793716 | [Is there a risk to prescribe paracetamol at therapeutic doses in patients with acute or chronic liver disease?] |
| Q79793728 | [Problems with therapeutic acetaminophen use in excessive drinkers] |
| Q33912798 | c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity |
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