Inhibition of mitochondrial complex I by rotenone protects against acetaminophen-induced liver injury

Inhibition of mitochondrial complex I by rotenone protects against acetaminophen-induced liver injury is …
instance of (P31):
scholarly articleQ13442814

External links are
P932PMC publication ID6357306
P698PubMed publication ID30787978

P2093author name stringYue Zhang
Aihua Zhang
Peipei Wang
Zhanjun Jia
Jiaqi Liu
Hu Hua
Songming Huang
Chunhua Zhu
Guixia Ding
Xuhua Ge
P2860cites workAcetaminophen-Induced Hepatotoxicity: a Comprehensive UpdateQ26746501
Mechanisms of drug-induced liver injuryQ26998806
Oxidative stress and pulmonary fibrosisQ27024861
The hepatic inflammatory response after acetaminophen overdose: role of neutrophilsQ28377336
Mitochondrial formation of reactive oxygen speciesQ29547906
Regulation of cell death: the calcium-apoptosis linkQ29615554
Mitochondria, oxidative stress and cell deathQ29618996
Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: attenuation by a lipophilic metalloporphyrinQ30524185
Toxicity of thallium on isolated rat liver mitochondria: the role of oxidative stress and MPT pore openingQ46726169
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicityQ46974191
Inhibition of mitochondrial complex I improves glucose metabolism independently of AMPK activationQ47438359
Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenalQ33790988
Mitochondria and neuronal survivalQ33807218
Mitochondrial Complex I: structural and functional aspectsQ33997495
Rotenone remarkably attenuates oxidative stress, inflammation, and fibrosis in chronic obstructive uropathyQ34033183
Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcomeQ34241967
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective studyQ34471434
Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failureQ34623585
Glutathione depletion and oxidative stressQ34826188
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicityQ35161427
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentationQ35858082
Inhibition of Mitochondrial Complex-1 Prevents the Downregulation of NKCC2 and ENaCα in Obstructive Kidney DiseaseQ35885150
Superoxide dismutase evolution and life span regulationQ36017386
Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropyQ36052377
Rotenone Attenuates Renal Injury in Aldosterone-Infused Rats by Inhibiting Oxidative Stress, Mitochondrial Dysfunction, and Inflammasome ActivationQ36187559
NADPH oxidase 4 regulates homocysteine metabolism and protects against acetaminophen-induced liver damage in miceQ36422396
Mitochondrial reactive oxygen species and Ca2+ signalingQ36499631
Interaction between cytokines and oxidative stress in acute pancreatitis.Q36638600
Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunityQ36652448
Cellular and molecular mechanisms of liver injuryQ36908855
Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosisQ37004604
Acetaminophen versus Ibuprofen in Young Children with Mild Persistent AsthmaQ37376047
Characterization of acetaminophen-induced cytotoxicity in target tissuesQ37393486
Impact of perinatal exposure to acetaminophen on hepatocellular metabolic function in offspringQ37553854
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicityQ37656707
Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety EvaluationQ37736766
Molecular mechanisms of the hepatotoxicity caused by acetaminophenQ38027602
A perspective on the epidemiology of acetaminophen exposure and toxicity in the United StatesQ38200112
2016 Update of the Italian Pediatric Society Guidelines for Management of Fever in ChildrenQ38997691
Troglitazone induced cytosolic acidification via extracellular signal-response kinase activation and mitochondrial depolarization: complex I proton pumping regulates ammoniagenesis in proximal tubule-like LLC-PK1 cellsQ39904448
Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injuryQ39935785
Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxiaQ40490848
Production of reactive oxygen species by mitochondria: central role of complex III.Q42163292
Azoxystrobin, a mitochondrial complex III Qo site inhibitor, exerts beneficial metabolic effects in vivo and in vitroQ42804138
Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivationQ43196333
Generation of reactive oxygen species by the mitochondrial electron transport chainQ43955844
Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria.Q44628561
Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I.Q46270264
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
hepatotoxicityQ1349821
P304page(s)188-198
P577publication date2019-01-01
P1433published inAmerican Journal of Translational ResearchQ4744272
P1476titleInhibition of mitochondrial complex I by rotenone protects against acetaminophen-induced liver injury
P478volume11

Reverse relations

Q93187696Escin protects against acetaminophen-induced liver injury in mice via attenuating inflammatory response and inhibiting ERK signaling pathwaycites workP2860

Search more.