Selective coupling of T-type calcium channels to SK potassium channels prevents intrinsic bursting in dopaminergic midbrain neurons.

scientific article published in May 2002

Selective coupling of T-type calcium channels to SK potassium channels prevents intrinsic bursting in dopaminergic midbrain neurons. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.22-09-03404.2002
P932PMC publication ID6758365
P698PubMed publication ID11978817

P50authorJochen RoeperQ39067279
P2093author name stringJakob Wolfart
P2860cites workMolecular characterization of a neuronal low-voltage-activated T-type calcium channelQ24316054
Structure and functional characterization of neuronal alpha 1E calcium channel subtypesQ24318421
Small-conductance, calcium-activated potassium channels from mammalian brainQ24318679
Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtypeQ24324250
Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channelQ24336849
Prospects for new restorative and neuroprotective treatments in Parkinson's diseaseQ28138668
Gating of information flow within the limbic system and the pathophysiology of schizophreniaQ28138727
Proteomic analysis of NMDA receptor-adhesion protein signaling complexesQ28138918
Small-conductance calcium-activated potassium channelsQ28140263
Structure and functional expression of a member of the low voltage-activated calcium channel familyQ28263366
Primary structure of the receptor for calcium channel blockers from skeletal muscleQ28288569
Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)Q28289820
Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neuronsQ28343155
Molecular and functional characterization of a family of rat brain T-type calcium channelsQ28573439
Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poisonQ29029753
Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channelsQ30303630
Pharmacological properties of Ca(V)3.2, a low voltage-activated Ca2+ channel cloned from human heartQ30655784
Mibefradil block of cloned T-type calcium channelsQ31440330
Immunohistochemical localization of voltage-gated calcium channels in substantia nigra dopamine neuronsQ32027852
The molecular basis of voltage-gated Ca2+ channel diversity: is it time for T?Q32102139
The physiological approach: functional architecture of working memory and disordered cognition in schizophreniaQ33725853
Afferent modulation of dopamine neuron firing patternsQ33801734
Calcium-activated potassium currents in mammalian neurons.Q34023031
Gating properties of single SK channels in hippocampal CA1 pyramidal neuronsQ34171440
Multiple reward signals in the brainQ34189430
The control of firing pattern in nigral dopamine neurons: single spike firingQ34248461
The control of firing pattern in nigral dopamine neurons: burst firingQ34248465
Rocking and rolling with Ca2+ channelsQ34321636
Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscleQ34633282
Primary structure and functional expression from complementary DNA of a brain calcium channelQ34779902
Functional dependence of Ca(2+)-activated K+ current on L- and N-type Ca2+ channels: differences between chicken sympathetic and parasympathetic neurons suggest different regulatory mechanismsQ35139372
Localization and functional properties of a rat brain alpha 1A calcium channel reflect similarities to neuronal Q- and P-type channelsQ35863195
Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neuronsQ35986050
Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophreniaQ36500321
Two distinct Ca-dependent K currents in bullfrog sympathetic ganglion cellsQ37687109
Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunitQ38313114
Reflections on Ca(2+)-channel diversity, 1988-1994.Q40400024
Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons.Q40714401
Cloning and expression of a novel member of the low voltage-activated T-type calcium channel familyQ40969230
Ca(2+)-activated K+ currents in neurones: types, physiological roles and modulationQ41003282
Low-threshold calcium currents in central nervous system neurons.Q41117703
Effects of dihydropyridine calcium antagonists on rat midbrain dopaminergic neuronesQ42123342
Electrophysiological and immunocytochemical characterization of GABA and dopamine neurons in the substantia nigra of the rat.Q42443841
Differential expression of the small-conductance, calcium-activated potassium channel SK3 is critical for pacemaker control in dopaminergic midbrain neurons.Q43594231
A cellular mechanism of reward-related learning.Q43729267
Somatic colocalization of rat SK1 and D class (Ca(v)1.2) L-type calcium channels in rat CA1 hippocampal pyramidal neurons.Q43757491
Statistical properties of neuronal spike trains in the substantia nigra: cell types and their interactionsQ44264555
Nifedipine- and omega-conotoxin-sensitive Ca2+ conductances in guinea-pig substantia nigra pars compacta neuronesQ46172559
Burst firing in dopamine neurons induced by N-methyl-D-aspartate: role of electrogenic sodium pumpQ47931189
Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitroQ47941797
Firing properties of substantia nigra dopaminergic neurons in freely moving ratsQ47951816
Electrophysiological properties of mouse dopamine neurons: in vivo and in vitro studiesQ47953812
Distribution of the voltage-dependent calcium channel alpha1G subunit mRNA and protein throughout the mature rat brainQ48130451
GABA(A) and GABA(B) antagonists differentially affect the firing pattern of substantia nigra dopaminergic neurons in vivoQ48201296
Blockade of SK-type Ca2+-activated K+ channels uncovers a Ca2+-dependent slow afterdepolarization in nigral dopamine neuronsQ48258165
Nifedipine blocks apamin-induced bursting activity in nigral dopamine-containing neuronsQ48305226
L-Type Ca2+ channels mediate the slow Ca2+-dependent afterhyperpolarization current in rat CA3 pyramidal cells in vitroQ48348962
Electrical membrane properties of rat substantia nigra compacta neurons in an in vitro slice preparationQ48353146
Selective activation of Ca2+-activated K+ channels by co-localized Ca2+ channels in hippocampal neuronsQ48357057
Bursts and recurrences of bursts in the spike trains of spontaneously active striate cortex neuronsQ48498245
Regulation of dopamine release by impulse flow and by autoreceptors as studied by in vivo voltammetry in the rat striatumQ48517596
Subtypes of substantia nigra dopaminergic neurons revealed by apamin: autoradiographic and electrophysiological studiesQ48522692
Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currentsQ48646633
Extracellular dopamine and neurotensin in rat prefrontal cortex in vivo: effects of median forebrain bundle stimulation frequency, stimulation pattern, and dopamine autoreceptorsQ48661645
Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels.Q48666040
Nomenclature of voltage-gated calcium channelsQ48750675
Repetitive firing properties of putative dopamine-containing neurons in vitro: regulation by an apamin-sensitive Ca(2+)-activated K+ conductanceQ48810963
Apamin-sensitive Ca(2+)-activated K+ channels regulate pacemaker activity in nigral dopamine neurons.Q49109580
Voltage-dependent calcium channels in rat midbrain dopamine neurons: modulation by dopamine and GABAB receptors.Q51596441
A whole cell patch-clamp study on the pacemaker potential in dopaminergic neurons of rat substantia nigra compacta.Q51649611
Calcium spike underlying rhythmic firing in dopaminergic neurons of the rat substantia nigra.Q51650016
Three types of neuronal calcium channel with different calcium agonist sensitivity.Q51824457
Addiction becomes a brain disease.Q52168559
Calcium release from internal stores is required for the generation of spontaneous hyperpolarizations in dopaminergic neurons of neonatal rats.Q53919018
Differential inhibition of Ca2+ channels in mature rat cerebellar Purkinje cells by sFTX-3.3 and FTX-3.3.Q54153714
Mechanism of calcium gating in small-conductance calcium-activated potassium channels.Q54432027
Low-voltage-activated (T-type) calcium-channel genes identifiedQ57839490
Effects of apamin on the discharge properties of putative dopamine-containing neurons in vitroQ67977797
Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cellsQ69036947
Sources of Ca2+ for different Ca(2+)-activated K+ conductances in neurones of the rat superior cervical ganglionQ71718752
Ca(2+)-induced Ca2+ release and its activation in response to a single action potential in rabbit otic ganglion cellsQ71750643
Apamin increases NMDA-induced burst-firing of rat mesencephalic dopamine neuronsQ72269302
A novel peptide from funnel web spider venom, omega-Aga-TK, selectively blocks, P-type calcium channelsQ72547100
Inositol 1,4,5-triphosphate-evoked responses in midbrain dopamine neuronsQ73066584
Dysfunctional brain dopamine systems induced by psychotomimetic NMDA-receptor antagonists and the effects of antipsychotic drugsQ73553193
Network interactions in schizophrenia - therapeutic implicationsQ73553195
Intracellular Ca2+ release contributes to automaticity in cat atrial pacemaker cellsQ73680778
Ca(2+) channels involved in the generation of the slow afterhyperpolarization in cultured rat hippocampal pyramidal neuronsQ73776254
Gating of Ca2+-activated K+ channels controls fast inhibitory synaptic transmission at auditory outer hair cellsQ74005798
Global structure, robustness, and modulation of neuronal modelsQ74139588
Burst firing in midbrain dopaminergic neuronsQ74293267
Pharmacological analysis of intracellular Ca2+ signalling: problems and pitfallsQ77455956
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectdopamineQ170304
P304page(s)3404-3413
P577publication date2002-05-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleSelective coupling of T-type calcium channels to SK potassium channels prevents intrinsic bursting in dopaminergic midbrain neurons
P478volume22

Reverse relations

cites work (P2860)
Q48007015A single compartment model of pacemaking in dissasociated substantia nigra neurons: stability and energy analysis
Q46862871Accumulation of cytoplasmic calcium, but not apamin-sensitive afterhyperpolarization current, during high frequency firing in rat subthalamic nucleus cells
Q36319813Active Dendrites and Differential Distribution of Calcium Channels Enable Functional Compartmentalization of Golgi Cells
Q33865323Aging decreases L-type calcium channel currents and pacemaker firing fidelity in substantia nigra dopamine neurons
Q44557615Apamin-sensitive small conductance calcium-activated potassium channels, through their selective coupling to voltage-gated calcium channels, are critical determinants of the precision, pace, and pattern of action potential generation in rat subthala
Q35610757Availability of low-threshold Ca2+ current in retinal ganglion cells
Q41775538Axon initial segment Ca2+ channels influence action potential generation and timing
Q42457865Balance between the proximal dendritic compartment and the soma determines spontaneous firing rate in midbrain dopamine neurons
Q93063989Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease
Q41484775CRF facilitates calcium release from intracellular stores in midbrain dopamine neurons
Q37266202Ca(2+) signaling by T-type Ca(2+) channels in neurons.
Q28283065Ca(2+)-activated K+ channels: molecular determinants and function of the SK family
Q48391941Ca2+ release-dependent hyperpolarizations modulate the firing pattern of juvenile GABA neurons in mouse substantia nigra pars reticulata in vitro
Q40998514Calcium-activated SK channels control firing regularity by modulating sodium channel availability in midbrain dopamine neurons.
Q83841998Calcium-activated non-selective cation currents are involved in generation of tonic and bursting activity in dopamine neurons of the substantia nigra pars compacta
Q47867263Calcium-activated potassium channels are selectively coupled to P/Q-type calcium channels in cerebellar Purkinje neurons.
Q46635637Carbachol induces burst firing of dopamine cells in the ventral tegmental area by promoting calcium entry through L-type channels in the rat.
Q42157357Cav1.3 channel voltage dependence, not Ca2+ selectivity, drives pacemaker activity and amplifies bursts in nigral dopamine neurons.
Q91198522Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease
Q44266745Characterization of pre- and post-synaptic metabotropic glutamate receptor-mediated inhibitory responses in substantia nigra dopamine neurons
Q47370739Cocaine Exposure Enhances the Activity of Ventral Tegmental Area Dopamine Neurons via Calcium-Impermeable NMDARs
Q46664802Coincidence detection of convergent perforant path and mossy fibre inputs by CA3 interneurons.
Q43238317Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice
Q36138209Contributions of T-Type Voltage-Gated Calcium Channels to Postsynaptic Calcium Signaling within Purkinje Neurons
Q28074143Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease
Q45981694Different calcium sources control somatic versus dendritic SK channel activation during action potentials.
Q36373801Differential Regulation of Action Potential Shape and Burst-Frequency Firing by BK and Kv2 Channels in Substantia Nigra Dopaminergic Neurons
Q47706923Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons.
Q35928704Differential regulation of action potential- and metabotropic glutamate receptor-induced Ca2+ signals by inositol 1,4,5-trisphosphate in dopaminergic neurons
Q37441435Discharge regularity in the turtle posterior crista: comparisons between experiment and theory
Q30425716Disruption of dopamine neuron activity pattern regulation through selective expression of a human KCNN3 mutation.
Q41666084Dopamine Inhibition Differentially Controls Excitability of Substantia Nigra Dopamine Neuron Subpopulations through T-Type Calcium Channels
Q36215993Dopamine Neurons Change the Type of Excitability in Response to Stimuli
Q37214730Duration differences of corticostriatal responses in striatal projection neurons depend on calcium activated potassium currents
Q34211245Dynamic regulation of midbrain dopamine neuron activity: intrinsic, synaptic, and plasticity mechanisms
Q37416721Endogenous calcium buffering capacity of substantia nigral dopamine neurons
Q41700371Enhanced Sensitivity to Hyperpolarizing Inhibition in Mesoaccumbal Relative to Nigrostriatal Dopamine Neuron Subpopulations.
Q46703446Enhancement of excitatory synaptic integration by GABAergic inhibition in the subthalamic nucleus.
Q27687624Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs
Q44270164Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins.
Q37128156Food restriction increases glutamate receptor-mediated burst firing of dopamine neurons
Q42134273Functional coupling between large-conductance potassium channels and Cav3.2 voltage-dependent calcium channels participates in prostate cancer cell growth.
Q35794531Functional diversity of ventral midbrain dopamine and GABAergic neurons
Q45282607Functional properties of dopaminergic neurones in the mouse olfactory bulb.
Q34532038Functional upregulation of Ca(2+)-activated K(+) channels in the development of substantia nigra dopamine neurons
Q37146696Gain control of synaptic response function in cerebellar nuclear neurons by a calcium-activated potassium conductance
Q41658206Gating of dopamine transmission by calcium and axonal N-, Q-, T- and L-type voltage-gated calcium channels differs between striatal domains.
Q37425764Genetic ablation of CaV3.2 channels enhances the arterial myogenic response by modulating the RyR-BKCa axis.
Q44897967Global dendritic calcium spikes in mouse layer 5 low threshold spiking interneurones: implications for control of pyramidal cell bursting
Q42470140HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons.
Q28080655Homeostasis or channelopathy? Acquired cell type-specific ion channel changes in temporal lobe epilepsy and their antiepileptic potential
Q30497725Hyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice
Q34379561Hypertension induced by angiotensin II and a high salt diet involves reduced SK current and increased excitability of RVLM projecting PVN neurons
Q36268875Impaired Cholinergic Excitation of Prefrontal Attention Circuitry in the TgCRND8 Model of Alzheimer's Disease
Q38943090Implications of cellular models of dopamine neurons for disease.
Q44423347Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior
Q104135027In vivo patch-clamp recordings reveal distinct subthreshold signatures and threshold dynamics of midbrain dopamine neurons
Q84890784Inactivating ion channels augment robustness of subthreshold intrinsic response dynamics to parametric variability in hippocampal model neurons
Q36873051Independent presynaptic and postsynaptic mechanisms regulate endocannabinoid signaling at multiple synapses in the ventral tegmental area.
Q44535418Influence of R-type (Cav2.3) and t-type (Cav3.1-3.3) antagonists on nigral somatodendritic dopamine release measured by microdialysis.
Q34875013Interaction of NMDA receptor and pacemaking mechanisms in the midbrain dopaminergic neuron
Q35787234Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells
Q21129445Intracellular calcium dynamics permit a Purkinje neuron model to perform toggle and gain computations upon its inputs
Q30846890Ionic currents influencing spontaneous firing and pacemaker frequency in dopamine neurons of the ventrolateral periaqueductal gray and dorsal raphe nucleus (vlPAG/DRN): A voltage-clamp and computational modelling study.
Q28271148Ionic mechanisms underlying autonomous action potential generation in the somata and dendrites of GABAergic substantia nigra pars reticulata neurons in vitro
Q38110757K(+) channels: function-structural overview.
Q41325979Location matters: somatic and dendritic SK channels answer to distinct calcium signals
Q44297280Maintenance of sympathetic tone by a nickel chloride-sensitive mechanism in the rostral ventrolateral medulla of the adult rat.
Q30493995Modulation of midbrain dopamine neurotransmission by serotonin, a versatile interaction between neurotransmitters and significance for antipsychotic drug action
Q28283415Modulation of the activity of dopaminergic neurons by SK channels: a potential target for the treatment of Parkinson's disease?
Q33560844Molecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain
Q28243759Neuronal T-type calcium channels: what's new? Iftinca: T-type channel regulation
Q34612710Noise normalizes firing output of mouse lateral geniculate nucleus neurons
Q34561823Non-linear developmental trajectory of electrical phenotype in rat substantia nigra pars compacta dopaminergic neurons.
Q42512408Nonselective cation channels are essential for maintaining intracellular Ca2+ levels and spontaneous firing activity in the midbrain dopamine neurons
Q41121791Ontogenic Changes and Differential Localization of T-type Ca(2+) Channel Subunits Cav3.1 and Cav3.2 in Mouse Hippocampus and Cerebellum
Q47314960Parkinson's Disease Is Not Simply a Prion Disorder
Q28833834Pharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1)
Q24813910Phobic memory and somatic vulnerabilities in anorexia nervosa: a necessary unity?
Q48122368Potassium Channels: A Potential Therapeutic Target for Parkinson's Disease
Q44786002Potassium attenuates zinc-induced death of cultured cortical astrocytes
Q47834739Potassium channel dysfunction in neurons and astrocytes in Huntington's disease.
Q34090446Regulation of firing frequency in a computational model of a midbrain dopaminergic neuron
Q28169166Rescue of mesencephalic dopaminergic neurons in culture by low-level stimulation of voltage-gated sodium channels
Q38399159Role of Calcium-activated Potassium Channels in Atrial Fibrillation Pathophysiology and Therapy.
Q30427731Role of voltage-gated calcium channels in epilepsy.
Q64081108Selective attenuation of Ether-a-go-go related K currents by endogenous acetylcholine reduces spike-frequency adaptation and network correlation
Q52586011Selective regulation of spontaneous activity of neurons of the deep cerebellar nuclei by N-type calcium channels in juvenile rats.
Q26850970Signal processing by T-type calcium channel interactions in the cerebellum
Q37915192Signaling complexes of voltage-gated calcium channels
Q40949695Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception.
Q47829763Similar nicotinic excitability responses across the developing hippocampal formation are regulated by small conductance calcium-activated potassium channels.
Q30276331Small-Conductance Ca2+-Activated Potassium Channels Negatively Regulate Aldosterone Secretion in Human Adrenocortical Cells
Q42027984Spike-rate coding and spike-time coding are affected oppositely by different adaptation mechanisms
Q34582876Spontaneous opening of T-type Ca2+ channels contributes to the irregular firing of dopamine neurons in neonatal rats
Q37322293Supramolecular assemblies and localized regulation of voltage-gated ion channels.
Q36927943Synergy of AMPA and NMDA Receptor Currents in Dopaminergic Neurons: A Modeling Study
Q88511743Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress
Q38322032T-type calcium channel Cav3.2 deficient mice show elevated anxiety, impaired memory and reduced sensitivity to psychostimulants
Q33747856T-type calcium channels contribute to NMDA receptor independent synaptic plasticity in hippocampal regular-spiking oriens-alveus interneurons
Q38177667T-type channels buddy up.
Q34092998T-type channels control the opioidergic descending analgesia at the low threshold-spiking GABAergic neurons in the periaqueductal gray
Q36437519Targeting N-type and T-type calcium channels for the treatment of pain
Q47852791The SK channel blocker apamin inhibits slow afterhyperpolarization currents in rat gonadotropin-releasing hormone neurones
Q34004305The action potential in mammalian central neurons
Q48457646The effects of aging on substantia nigra dopamine neurons.
Q38138513The many faces of T-type calcium channels
Q89759609The mechanisms shaping CA2 pyramidal neuron action potential bursting induced by muscarinic acetylcholine receptor activation
Q36737164The relationship between single-channel and whole-cell conductance in the T-type Ca2+ channel CaV3.1.
Q35288972The subcellular distribution of T-type Ca2+ channels in interneurons of the lateral geniculate nucleus
Q36236383Transient Activation of GABAB Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons
Q91721563Trpc5 deficiency causes hypoprolactinemia and altered function of oscillatory dopamine neurons in the arcuate nucleus

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