Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine

scientific article published in April 2002

Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0006-2952(02)00906-1
P698PubMed publication ID11996884

P2093author name stringAnthony E Pegg
Natalia A Loktionova
P2860cites workHyperthermostable protein structure maintained by intra and inter-helix ion-pairs in archaeal O6-methylguanine-DNA methyltransferaseQ27619727
Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferaseQ27620779
Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base bindingQ27622042
Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferaseQ28268090
Repair of DNA containing O6-alkylguanineQ28284603
Regulation and expression of the adaptive response to alkylating agentsQ28289093
Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cellsQ30663736
Characterization of cDNA encoding mouse DNA repair protein O6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in Escherichia coliQ30736503
Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vectorQ31853786
Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant gliomaQ33334642
Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agentsQ33689518
Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferaseQ34006340
The suicidal DNA repair methyltransferases of microbesQ36200499
Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanineQ38314205
Genetic polymorphism of human O6-alkylguanine-DNA alkyltransferase: identification of a missense variation in the active site regionQ38325818
Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chainQ40987553
Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitroQ41007279
Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosoureaQ41236881
A polymorphism at codon 160 of human O6 methylguanine-DNA methyltransferase gene in young patients with adult type cancers and functional assayQ41671919
Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanineQ42046696
Inactivation of O(6)-methylguanine-DNA methyltransferase by glucose-conjugated inhibitorsQ43658868
Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanineQ45859509
Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapyQ45863801
Characterization of human polymorphic DNA repair methyltransferase.Q53411914
8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.Q53466577
Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferaseQ53486098
Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanineQ53495189
Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidineQ67975150
Polymorphism in the human O6-methylguanine-DNA methyltransferase gene detected by PCR-SSCP analysisQ71690609
Activation of human O6-alkylguanine-DNA alkyltransferase by DNAQ72061933
The role of two conserved amino acids, glutamine 90 and asparagine 137, in O6-methylguanine-DNA methyltransferase stability, activity and substrate specificityQ72711282
Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferaseQ72774928
O6-benzylguanine in humans: metabolic, pharmacokinetic, and pharmacodynamic findingsQ74545960
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)1431-1442
P577publication date2002-04-01
P1433published inBiochemical PharmacologyQ864229
P1476titleInteraction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine
P478volume63

Reverse relations

cites work (P2860)
Q43104952Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase
Q59198949Chapter 5 Molecular Mechanisms of 4‐(Methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone‐Induced Lung Carcinogenesis
Q36012002DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy
Q37038938Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality

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