Do structural properties explain the anticonvulsant activity of valproate metabolites? A QSAR analysis

scientific article published in May 2002

Do structural properties explain the anticonvulsant activity of valproate metabolites? A QSAR analysis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1046/J.1528-1157.2002.365011.X
P698PubMed publication ID12027907

P2093author name stringAlejandro A Nava-Ocampo
Angélica M Bello-Ramírez
Blanca Y Carreón-Garabito
P2860cites workValproate metabolites in serum and urine during antiepileptic therapy in children with infantile spasms: abnormal metabolite pattern associated with reversible hepatotoxicityQ28324498
Asymmetric synthesis and enantioselective teratogenicity of 2-n-propyl-4-pentenoic acid (4-en-VPA), an active metabolite of the anticonvulsant drug, valproic acidQ28341501
Side effects of valproateQ30461785
Hematologic toxicity of sodium valproateQ33331641
Multiorgan system failure caused by valproic acid toxicityQ42055769
Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsyQ42249084
Effects of valproate and E-2-en-valproate on functional and morphological parameters of rat liver. I. Biochemical, histopathological and pharmacokinetic studiesQ43405786
Hydrophilic, pro-drug analogues of T138067 are efficacious in controlling tumor growth in vivo and show a decreased ability to cross the blood brain barrierQ43770015
Valproate metabolites in the rat brain--regional distribution in various brain areasQ48158853
Hydrophobicity and central nervous system agents: on the principle of minimal hydrophobicity in drug designQ48208266
Molecular factors influencing drug transfer across the blood-brain barrierQ48534771
Beta-oxidation of valproate. II. Effects of fasting, glucose, and clofibrate in rats.Q51618721
Beta-oxidation of valproic acid. I. Effects of fasting and glucose in humans.Q51618724
Valproate (VPA) metabolites in various clinical conditions of probable VPA-associated hepatotoxicity.Q53023073
P433issue5
P304page(s)475-481
P577publication date2002-05-01
P1433published inEpilepsiaQ5382969
P1476titleDo structural properties explain the anticonvulsant activity of valproate metabolites? A QSAR analysis
P478volume43

Reverse relations

cites work (P2860)
Q45153296A QSAR analysis of toxicity of Aconitum alkaloids
Q54353652A QSAR analysis to explain the analgesic properties of Aconitum alkaloids.
Q44751499Lipophilicity affects the pharmacokinetics and toxicity of local anaesthetic agents administered by caudal block
Q38258233QSAR and 3D-QSAR studies applied to compounds with anticonvulsant activity.
Q53767428QSPR Study of Valproic Acid and Its Functionalized Derivatives.
Q44831593The local anesthetic activity of Aconitum alkaloids can be explained by their structural properties: a QSAR analysis

Search more.