Valproate metabolites in the rat brain--regional distribution in various brain areas

scientific article

Valproate metabolites in the rat brain--regional distribution in various brain areas is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/BF03190017
P698PubMed publication ID10412898

P2093author name stringK Andreas
F P Meyer
E Bergsträsser
J Darius
E Ebermann
P2860cites workA multicentre comparative trial of sodium valproate and carbamazepine in adult onset epilepsy. Adult EPITEG Collaborative GroupQ33732579
Distribution of valproate across the interface between blood and cerebrospinal fluidQ40936823
Quantitative structure-anticonvulsant activity relationships of valproic acid, related carboxylic acids and tetrazolesQ42208907
Anticonvulsant and neurotoxic activities of twelve analogues of valproic acidQ42287628
Valproic acid in amygdala-kindled rats: alterations in anticonvulsant efficacy, adverse effects and drug and metabolite levels in various brain regions during chronic treatmentQ44592495
Regional distribution of RNA and protein radioactivity in the rat brain after intraventricular application of labeled precursorsQ47925256
Pharmacokinetics, anticonvulsant efficacy, and adverse effects of trans-2-en-valproate after acute and chronic administration in amygdala-kindled ratsQ48536406
Distribution of valproic acid and its metabolites in various brain areas of dogs and rats after acute and prolonged treatment.Q48748615
The anticonvulsant valproic acid concentrates in the olfactory bulb: selective laminar localizationQ48860007
Uptake of valproic acid into rat brain is mediated by a medium-chain fatty acid transporter.Q49082310
[The effect of valproic acid monotherapy on behavior and cognitive performance of children with idiopathic generalized epilepsy]Q52206407
Pharmacological evaluation of various metabolites and analogues of valproic acid. Anticonvulsant and toxic potencies in miceQ69956334
Marked increase in anticonvulsant activity but decrease in wet-dog shake behaviour during short-term treatment of amygdala-kindled rats with valproic acidQ70402503
A comparison of the effects of valproate and its major active metabolite E-2-en-valproate on single unit activity of substantia nigra pars reticulata neurons in ratsQ71152651
Anticonvulsant activity of metabolites of valproic acidQ71545222
Valproic acid: brain and plasma levels of the drug and its metabolites, anticonvulsant effects and gamma-aminobutyric acid (GABA) metabolism in the mouseQ71590878
On-column gas chromatographic-mass spectrometric assay for metabolic profiling of valproate in brain tissue and serumQ71593905
Determination of valproic acid and its metabolites using gas chromatography with mass-selective detection: application to serum and urine samples from sheepQ71953739
Distribution of Unsaturated Metabolites of Valproate in Human and Rat Brain‐Pharmacologic Relevance?Q71957859
Structure-Activity Relationships of Unsaturated Analogs of Valproic AcidQ71998493
P433issue1
P304page(s)97-104
P577publication date1999-01-01
P1433published inEuropean Journal of Drug Metabolism and PharmacokineticsQ15757261
P1476titleValproate metabolites in the rat brain--regional distribution in various brain areas
P478volume24

Reverse relations

cites work (P2860)
Q44004462Do structural properties explain the anticonvulsant activity of valproate metabolites? A QSAR analysis
Q35172584Valproic acid inhibits neural progenitor cell death by activation of NF-κB signaling pathway and up-regulation of Bcl-XL.

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