Laminin receptor on platelets is the integrin VLA-6.

scientific article published in December 1988

Laminin receptor on platelets is the integrin VLA-6. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1042076812
P356DOI10.1038/336487A0
P698PubMed publication ID2973567

P2093author name stringModderman PW
Sonnenberg A
Hogervorst F
P2860cites workHuman blood platelets showing no response to collagen fail to express surface glycoprotein IaQ28114845
Isolation of a tumor cell laminin receptorQ28265260
New perspectives in cell adhesion: RGD and integrinsQ28280381
Integrins: a family of cell surface receptorsQ28288125
Isolation of a laminin-binding protein from muscle cell membranesQ28295181
Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptorsQ28645681
Exposure of platelet fibrinogen receptors by ADP and epinephrineQ33473239
Fibronectin receptor structures in the VLA family of heterodimersQ34684589
Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptorQ34686171
Platelet glycoproteins Ia, Ic, and IIa are physicochemically indistinguishable from the very late activation antigens adhesion-related proteins of lymphocytes and other cell typesQ35809833
Isolation of a cell surface receptor protein for laminin from murine fibrosarcoma cellsQ36208241
Mapping of domains in human laminin using monoclonal antibodies: localization of the neurite-promoting siteQ36216567
Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunitsQ36216852
An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in an divalent cation-dependent functional complex with the disialoganglioside GD2.Q36217603
Glycoprotein Ic-IIa functions as an activation-independent fibronectin receptor on human plateletsQ36218390
Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding.Q55487135
Interaction of fibronectin with its receptor on plateletsQ68939916
Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagenQ69615135
Isolation and characterization of a platelet surface collagen binding complex related to VLA-2Q69828706
Characteristics of collagen-induced fibrinogen binding to human plateletsQ70057315
P433issue6198
P407language of work or nameEnglishQ1860
P304page(s)487-489
P577publication date1988-12-01
P1433published inNatureQ180445
P1476titleLaminin receptor on platelets is the integrin VLA-6.
P478volume336

Reverse relations

cites work (P2860)
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Q71650239Crohn's disease, ulcerative colitis, and normal intestinal lymphocytes express integrins in dissimilar patterns
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Q36530192Cytoplasmic and transmembrane domains of integrin beta 1 and beta 3 subunits are functionally interchangeable
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Q40640971Human colon carcinoma cells use multiple receptors to adhere to laminin: involvement of alpha 6 beta 4 and alpha 2 beta 1 integrins
Q42036744Human microvascular endothelial cells use beta 1 and beta 3 integrin receptor complexes to attach to laminin
Q36350914Human neutrophil adherence to laminin in vitro. Evidence for a distinct neutrophil integrin receptor for laminin
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Q42098553Identification of a novel form of the alpha 3 integrin subunit: covalent association with transferrin receptor
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Q68738265Identification of the Arg-Gly-Asp sequence in laminin A chain as a latent cell-binding site being exposed in fragment P1
Q35831087Immunohistochemical localization of integrins in the normal, hyperplastic, and neoplastic breast. Correlations with their functions as receptors and cell adhesion molecules
Q53738755Immunohistochemical study of extracellular matrix in acute galactosamine hepatitis in rats
Q42489355Immunolocalization of alpha 2, alpha 5, and alpha 6 integrin subunits in salivary tissue and adenomas of the parotid gland.
Q33428926Immunology of platelet disorders
Q41593571In vitro model of angiogenesis using a human endothelium‐derived permanent cell line: Contributions of induced gene expression, G‐proteins, and integrins
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Q51358107Increased circulating anti-α6-integrin autoantibodies in psoriasis and psoriatic arthritis but not in rheumatoid arthritis.
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Q41653661Integrin alpha 2 beta 1 is upregulated in fibroblasts and highly aggressive melanoma cells in three-dimensional collagen lattices and mediates the reorganization of collagen I fibrils
Q36529725Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion
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Q37711750Integrin structure and function in hemostasis and thrombosis
Q91956208Integrin α-3 ß-1's central role in breast cancer, melanoma and glioblastoma cell aggregation revealed by antibodies with blocking activity
Q36015267Integrin-mediated laminin-1 adhesion upregulates CXCR4 and IL-8 expression in pancreatic cancer cells
Q41530309Integrin-mediated neurite outgrowth in neuroblastoma cells depends on the activation of potassium channels.
Q40769921Integrin-type extracellular matrix receptors in cancer and inflammation
Q36529751Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface
Q28142460Integrins as receptors for laminins
Q41953774Integrins in point contacts mediate cell spreading: factors that regulate integrin accumulation in point contacts vs. focal contacts
Q42485822Integrins of normal human epidermis: differential expression, synthesis and molecular structure
Q41929293Interaction of human platelets with laminin and identification of the 67 kDa laminin receptor on platelets
Q36222270Isolation and characterization of Chinese hamster ovary cell variants deficient in the expression of fibronectin receptor
Q35199223Knockdown of the β(1) integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis
Q36946085Laminin enhances binding of Toxoplasma gondii tachyzoites to J774 murine macrophage cells
Q37922166Laminin in neuronal development
Q33281763Laminin isoforms in development and disease
Q42133183Laminin mediates tethering and spreading of colon cancer cells in physiological shear flow
Q30436976Laminin nanofiber meshes that mimic morphological properties and bioactivity of basement membranes
Q36971676Laminin on Toxoplasma gondii mediates parasite binding to the beta 1 integrin receptor alpha 6 beta 1 on human foreskin fibroblasts and Chinese hamster ovary cells
Q36529583Laminin receptors in the retina: sequence analysis of the chick integrin alpha 6 subunit. Evidence for transcriptional and posttranslational regulation
Q35633068Laminin receptors: achieving specificity through cooperation
Q41303127Laminin responsiveness is associated with changes in fibroblast morphology, motility, and anchorage‐independent growth: Cell system for examining the interaction between laminin and EGF signaling pathways
Q73520520Laminin-5 and modulation of keratin cytoskeleton arrangement in FG pancreatic carcinoma cells: involvement of IFAP300 and evidence that laminin-5/cell interactions correlate with a dephosphorylation of alpha 6A integrin
Q24594924Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes
Q42449978Localization of ahe 6 and 4 integrin subunits in normal human nonlymphoid tissues
Q42754749Localization of beta 1 integrins and their extracellular ligands in human lymphoid tissues
Q42477824Localization of integrin subunits alpha 6 and beta 1 during somitogenesis in the long-tailed macaque (M. fascicularis).
Q73838386Loss of alpha-v integrin expression and recurrence in node-negative lung carcinoma
Q38424785Matriglycan: a novel polysaccharide that links dystroglycan to the basement membrane.
Q35606319Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV
Q34487656Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor for sperm fertilinbeta
Q24323587Merosin, a tissue-specific basement membrane protein, is a laminin-like protein
Q41644962Migration of a Human Keratinocyte Cell Line (HACAT) to Interstitial Collagen Type I Is Mediated by the α2β1-Integrin Receptor
Q67899328Modulative effects of cell adhesion peptide (Arg-Gly-Asp-Ser) on the aggregation of stimulated platelets from ophthalmic patients
Q28277151Molecular Cloning of the cDNA Encoding Human Laminin A Chain
Q28290410Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes
Q34784548Molecular cloning of the rat integrin alpha 1-subunit: a receptor for laminin and collagen
Q36954760Molecular genetic aspects of human platelet antigen systems
Q71823689Monoclonal Antibody 9EG7 Defines a Novel β1 Integrin Epitope Induced by Soluble Ligand and Manganese, but Inhibited by Calcium
Q30464273Mouse egg integrin alpha 6 beta 1 functions as a sperm receptor.
Q41649553Mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Its binding motif for alpha 4 beta 7 and role in experimental colitis
Q43107899Multiple cell surface receptors for the short arms of laminin: alpha 1 beta 1 integrin and RGD-dependent proteins mediate cell attachment only to domains III in murine tumor laminin
Q40348064Neutrophil bactericidal activity against Staphylococcus aureus adherent on biological surfaces. Surface-bound extracellular matrix proteins activate intracellular killing by oxygen-dependent and -independent mechanisms
Q36742943New tools for studying microglia in the mouse and human CNS.
Q36328259Normal fertilization occurs with eggs lacking the integrin alpha6beta1 and is CD9-dependent
Q71612530Outer root sheath (ORS) cells organize into epidermoid cyst-like spheroids when cultured inside Matrigel: a light-microscopic and immunohistological comparison between human ORS cells and interfollicular keratinocytes
Q36371472PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane
Q34017429PECAM-1 functions as a negative regulator of laminin-induced platelet activation
Q62604231Peptide G, Containing the Binding Site of the 67-kDa Laminin Receptor, Increases and Stabilizes Laminin Binding to Cancer Cells
Q28588951Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen
Q40818063Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel.
Q40262641Phorbol ester induces a transient increase in alpha(5)beta(1)-mediated adhesion of the megakaryoblastic cell line CHRF 288-11.
Q30500244Phosphorylation of a conserved integrin alpha 3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement
Q44522050Platelet Integrins in Tumor Metastasis: Do They Represent a Therapeutic Target?
Q37711745Platelet adhesion to extracellular matrices of cultured cells
Q64122036Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting
Q36877378Platelet integrins and immunoreceptors
Q38666940Platelet membrane glycoproteins and their function: an overview
Q37982455Platelet signaling-a primer.
Q38542454Platelets and Their Interactions with Other Immune Cells
Q35477800Platelets and cancer metastasis: a causal relationship?
Q35119417Platelets in hemostasis and thrombosis: role of integrins and their ligands.
Q33777898Polarized integrin mediates human keratinocyte adhesion to basal lamina
Q41516285Polymerase chain reaction and focal contact formation indicate integrin expression in mesangial cells
Q54192720Promotion of human oral squamous cell carcinoma adhesion in vitro by the carboxy-terminal globular domain of laminin
Q41052471Psoriasiform architecture of murine epidermis overlying human psoriatic dermis transplanted onto SCID mice
Q24301078Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin
Q74316491Purification of integrins and characterization of integrin-associated proteins
Q28566512Rat seminiferous epithelium contains a unique junction (Ectoplasmic specialization) with signaling properties both of cell/cell and cell/matrix junctions
Q36529067Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations
Q36223725Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha 6 subunit is essential for epithelial polarization in developing kidney tubules
Q41598446Recombinant laminin B1 chains exhibit intact short-arm domains but do not form oligomeric molecules
Q35651723Reconstruction of integrin activation
Q43680073Regulated expression and binding of three VLA (beta 1) integrin receptors on T cells
Q36383304Regulation of alpha 6 beta 1 integrin laminin receptor function by the cytoplasmic domain of the alpha 6 subunit
Q34443560Regulation of cellular interactions with laminin by integrin cytoplasmic domains: the A and B structural variants of the alpha 6 beta 1 integrin differentially modulate the adhesive strength, morphology, and migration of macrophages
Q41811254Regulation of cytosolic calcium by collagen in single human platelets
Q41835080Regulation of extracellular matrix proteins and integrin cell substratum adhesion receptors on epithelium during cutaneous human wound healing in vivo
Q36693040Regulation of human neural precursor cells by laminin and integrins
Q41272684Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.
Q67765307Regulation of integrin-type cell adhesion receptors by cytokines
Q52163310Regulation of laminin-associated integrin subunit mRNAs in rat spinal motoneurons during postnatal development and after axonal injury.
Q41909450Regulation of the VLA integrin-ligand interactions through the beta 1 subunit
Q29614313Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
Q34000510Role of Bordetella pertussis virulence factors in adherence to epithelial cell lines derived from the human respiratory tract
Q72660215Role of LFA-1/ICAM-1 in interleukin-2-stimulated lymphocyte proliferation
Q42755431Role of beta 1-integrins in epidermotropism of malignant T cells.
Q77716515Role of beta1 integrins in adhesion and invasion of hepatocellular carcinoma cells
Q28281815Schwann cells secrete a novel collagen-like adhesive protein that binds N-syndecan
Q33470320Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by f.p.l.c. Characterization by monoclonal antibodies and gas-phase sequencing
Q37597345Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins
Q36222822Signal transduction for chemotaxis and haptotaxis by matrix molecules in tumor cells
Q41652759Skeletal myoblasts utilize a novel beta 1-series integrin and not alpha 6 beta 1 for binding to the E8 and T8 fragments of laminin
Q43265390Sonic hedgehog regulates integrin activity, cadherin contacts, and cell polarity to orchestrate neural tube morphogenesis
Q28294878Specific association of CD63 with the VLA-3 and VLA-6 integrins
Q55066384Specific induction of cell motility on laminin by alpha 7 integrin.
Q71643221Stem Cell Factor Regulates Human Melanocyte‐Matrix Interactions
Q41248161Stimulation of endothelial cell migration in culture by ladsin, a laminin-5-like cell adhesion protein
Q92050933Structural biology of laminins
Q24536159Structure and function of the platelet integrin alphaIIbbeta3
Q33909935Studies of activated GPIIb/IIIa receptors on the luminal surface of adherent platelets. Paradoxical loss of luminal receptors when platelets adhere to high density fibrinogen
Q36532915Synthetic peptides from the carboxy-terminal globular domain of the A chain of laminin: their ability to promote cell adhesion and neurite outgrowth, and interact with heparin and the beta 1 integrin subunit
Q33381441The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend
Q36717020The Molecular Biology of Platelet Membrane Glycoproteins
Q36529544The NC1 domain of type IV collagen promotes axonal growth in sympathetic neurons through interaction with the alpha 1 beta 1 integrin
Q36223077The activation dependent adhesion of macrophages to laminin involves cytoskeletal anchoring and phosphorylation of the alpha 6 beta 1 integrin
Q42160122The alpha 1-alpha 6 subunits of integrins are characteristically expressed in distinct segments of developing and adult human nephron
Q36223031The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin
Q36614617The alpha2beta1 integrin mediates the malignant phenotype on type I collagen in pancreatic cancer cell lines
Q44552409The alphavbeta5 integrin of hematopoietic and nonhematopoietic cells is a transduction receptor of RGD-4C fiber-modified adenoviruses
Q40629952The dynamic regulation of integrin adhesiveness
Q41331763The fibrinoids of the human placenta: origin, composition and functional relevance.
Q42125827The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho.
Q34325720The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others
Q36531324The integrin alpha 6 beta 4 is a laminin receptor
Q46529182The integrin complex αvβ3 participates in the adhesion of microvascular endothelial cells to fibronectin
Q37956452The invasive phenotypes
Q40883080The laminins: a family of basement membrane glycoproteins important in cell differentiation and tumor metastases
Q24683842The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunit
Q28508336The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin
Q42771139The mucin epiglycanin on TA3/Ha carcinoma cells prevents alpha 6 beta 4-mediated adhesion to laminin and kalinin and E-cadherin-mediated cell-cell interaction
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