Inhibition of Rho/Rho-kinase signaling downregulates plasminogen activator inhibitor-1 synthesis in cultured human monocytes

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Inhibition of Rho/Rho-kinase signaling downregulates plasminogen activator inhibitor-1 synthesis in cultured human monocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0167-4889(02)00201-X
P698PubMed publication ID12063175

P2093author name stringYoh Takuwa
Tamio Teramoto
Yukio Maruyama
Koichi Sugimoto
Kenji Nagata
Keiko Yokoyama
Toshiyuki Ishibashi
Hiroshi Ohkawara
Sotaro Sakurada
Takayuki Sakamoto
Joji Shindo
P2860cites workA rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Posttranslational modification of proteins by isoprenoids in mammalian cellsQ28303329
Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinaseQ28354356
Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3Q28582315
The coagulation cascade: initiation, maintenance, and regulationQ28610148
Regulation of the mevalonate pathwayQ29547763
The pathogenesis of atherosclerosis: a perspective for the 1990sQ29547827
The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigatorsQ29547887
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertensionQ29614247
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study GroupQ29619842
Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol LevelsQ29620696
A new model of cerebral microthrombosis in rats and the neuroprotective effect of a Rho-kinase inhibitorQ30920719
The role of Rho in G protein-coupled receptor signal transductionQ33932175
Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.Q33953572
3-Hydroxy-3-methylglutaryl CoA reductase inhibitors up-regulate transforming growth factor-beta signaling in cultured heart cells via inhibition of geranylgeranylation of RhoA GTPaseQ35654989
Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteriesQ37131350
Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study GroupQ39522420
Molecular bases of the acute coronary syndromesQ40530238
Distinct signaling pathways for MCP-1-dependent integrin activation and chemotaxisQ40817145
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteinsQ41005307
Modulation of expression of monocyte/macrophage plasminogen activator activity and its implications for attenuation of vasculopathyQ41438612
Effects of blockade of the renin-angiotensin system on tissue factor and plasminogen activator inhibitor-1 synthesis in human cultured monocytesQ43593692
Critical role of Rho-kinase and MEK/ERK pathways for angiotensin II-induced plasminogen activator inhibitor type-1 gene expressionQ43604739
Potentiation by hypercholesterolemia of the induction of aortic intramural synthesis of plasminogen activator inhibitor type 1 by endothelial injuryQ72094659
Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park Heart StudyQ72235431
Association of fibrinolytic parameters with early atherosclerosis. The ARIC Study. Atherosclerosis Risk in Communities StudyQ72369100
Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivoQ73178265
Beneficial effects of pravastatin (+/-colestyramine/niacin) initiated immediately after a coronary event (the randomized Lipid-Coronary Artery Disease [L-CAD] Study)Q73289471
HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cellsQ73435193
Expression of very low density lipoprotein receptor mRNA in circulating human monocytes: its up-regulation by hypoxiaQ73630854
Increased plasminogen activator inhibitor-1 and apolipoprotein (a) in coronary atherectomy specimens in acute coronary syndromesQ77199227
Granulocyte-macrophage colony-stimulating factor prevents the progression of atherosclerosis via changes in the cellular and extracellular composition of atherosclerotic lesions in watanabe heritable hyperlipidemic rabbitsQ77367269
Increased plasminogen activator inhibitor-1 and vasculopathy. A reconcilable paradoxQ77756570
Are we mortgaging the medical profession?Q95814757
P433issue1-3
P921main subjectplasminogenQ107129060
P304page(s)123-130
P577publication date2002-06-01
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleInhibition of Rho/Rho-kinase signaling downregulates plasminogen activator inhibitor-1 synthesis in cultured human monocytes
P478volume1590

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cites work (P2860)
Q37170931Comparison of effects of rosuvastatin (10 mg) versus atorvastatin (40 mg) on rho kinase activity in caucasian men with a previous atherosclerotic event
Q35200997Effects of HMG-CoA reductase inhibitors on coagulation and fibrinolysis processes
Q40616218Increased Expression of Plasminogen Activator Inhibitor-1 by Mediators of the Acute Phase Response: a Potential Progenitor of Vasculopathy in Hypertensives
Q42442226Intracellular signal transduction modulating expression of plasminogen activator inhibitor-1 in adipocytes
Q40387534Mechanisms of statin-mediated inhibition of small G-protein function
Q37403235Pleiotropic vasoprotective effects of statins: the chicken or the egg?
Q43699737Simvastatin alters fibroblastic cell responses involved in tissue repair
Q33882829Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes
Q36768488Statins as first-line therapy for acute coronary syndrome?
Q37639928Statins for community-acquired pneumonia: current state of the science.
Q37276466Statins in the first-line therapy of acute coronary syndrome - similar to aspirin?
Q46210874Statins suppress glucose-induced plasminogen activator inhibitor-1 expression by regulating RhoA and nuclear factor-κB activities in cardiac microvascular endothelial cells
Q54589738The 4G/5G PAI-1 polymorphism influences the endothelial response to IL-1 and the modulatory effect of pravastatin.
Q35153749The lipid and non-lipid effects of statins

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