Combination of 22-oxa-1,25-dihydroxyvitamin D(3), a vitamin D(3) derivative, with vitamin K(2) (VK2) synergistically enhances cell differentiation but suppresses VK2-inducing apoptosis in HL-60 cells

scientific article published in August 2002

Combination of 22-oxa-1,25-dihydroxyvitamin D(3), a vitamin D(3) derivative, with vitamin K(2) (VK2) synergistically enhances cell differentiation but suppresses VK2-inducing apoptosis in HL-60 cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.LEU.2402614
P698PubMed publication ID12145693
P5875ResearchGate publication ID11236302

P2093author name stringK Miyazawa
K Ohyashiki
M Yaguchi
K Funato
A Gotoh
P2860cites workAll-trans-retinoic acid in acute promyelocytic leukemiaQ28250406
A Novel Vitamin D3Analog, 22-Oxa-1, 25- Dihydroxyvitamin D3, Inhibits the Growth of Human Breast Cancerin Vitroandin Vivowithout Causing Hypercalcemia*Q28327218
Activation of extracellular signal-regulated kinases (ERKs) defines the first phase of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cellsQ31910647
Vitamin D receptor and nuclear receptor coactivators: crucial interactions in vitamin D-mediated transcriptionQ31943081
Vitamin D analogs: perspectives for treatmentQ33842033
Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiationQ33890494
Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3Q35462970
The Noncalcemic Analogue of Vitamin D, 22-Oxacalcitriol, Suppresses Parathyroid Hormone Synthesis and SecretionQ37000144
Induction of differentiation in normal human keratinocytes by adenovirus-mediated introduction of the eta and delta isoforms of protein kinase C.Q39575845
Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analogQ39610821
Combination of granulocyte colony-stimulating factor and low-dose cytosine arabinoside further enhances myeloid differentiation in leukemia cells in vitroQ40856553
p27Kip1 accumulation is associated with retinoic-induced neuroblastoma differentiation: evidence of a decreased proteasome-dependent degradationQ40904577
Key role of the cyclin-dependent kinase inhibitor p27kip1 for embryonal carcinoma cell survival and differentiation.Q40912314
Overexpression of p21WAF1/CIP1 induces cell differentiation and growth inhibition in a human glioma cell lineQ41065051
Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acidQ41108235
Novel role of vitamin K2: a potent inducer of differentiation of various human myeloid leukemia cell linesQ41411050
1alpha,25-dihydroxyvitamin D(3)-induced myeloid cell differentiation is regulated by a vitamin D receptor-phosphatidylinositol 3-kinase signaling complexQ42947245
Apoptosis/differentiation-inducing effects of vitamin K2 on HL-60 cells: dichotomous nature of vitamin K2 in leukemia cellsQ43676408
Sustained haematological response to high-dose oral alfacalcidol in patients with myelodysplastic syndromesQ45140094
Vitamin K-dependent gamma-carboxylation of the 1,25-dihydroxyvitamin D3 receptorQ46426452
Acute promyelocytic leukemia: a curable disease.Q53349932
Vitamin D treatment in myelodysplastic syndromes.Q53957961
Synthetic analogues of vitamin D3 with an oxygen atom in the side chain skeleton. A trial of the development of vitamin D compounds which exhibit potent differentiation-inducing activity without inducing hypercalcemiaQ69814191
Vitamin D analogs, 20-Epi-22-oxa-24a,26a,27a,-trihomo-1alpha,25(OH)2-vitamin D3, 1,24(OH)2-22-ene-24-cyclopropyl-vitamin D3 and 1alpha,25(OH)2-lumisterol3 prime NB4 leukemia cells for monocytic differentiation via nongenomic signaling pathways, invoQ73025320
Nuclear vitamin K2 binding protein in human osteoblasts: homologue to glyceraldehyde-3-phosphate dehydrogenaseQ73118120
Effect of 22-oxacalcitriol on bone histology of hemodialyzed patients with severe secondary hyperparathyroidismQ73487063
Vitamin K2 therapy for myelodysplastic syndromes (MDS) and post-MDS acute myeloid leukemia: information through a questionnaire survey of multi-center pilot studies in JapanQ73922314
Vitamin K2 selectively induces apoptosis of blastic cells in myelodysplastic syndrome: flow cytometric detection of apoptotic cells using APO2.7 monoclonal antibodyQ77299332
Vitamin K2 combined with all-trans retinoic acid induced complete remission of relapsing acute promyelocytic leukaemiaQ77597740
Leukemia cell differentiation: cellular and molecular interactions of retinoids and vitamin DQ77794161
P433issue8
P921main subjectvitaminQ34956
cell differentiationQ210861
vitamin DQ175621
vitamin KQ182338
P304page(s)1519-1527
P577publication date2002-08-01
P1433published inLeukemiaQ6534498
P1476titleCombination of 22-oxa-1,25-dihydroxyvitamin D(3), a vitamin D(3) derivative, with vitamin K(2) (VK2) synergistically enhances cell differentiation but suppresses VK2-inducing apoptosis in HL-60 cells
P478volume16

Reverse relations

cites work (P2860)
Q81315791Assessment of the international prognostic scoring system for determining chemotherapeutic indications in myelodysplastic syndrome: Japanese retrospective multicenter study
Q38742818Detection of subclinical vitamin K deficiency in neurosurgery with PIVKA-II.
Q92679872E2F4 functions as a tumour suppressor in acute myeloid leukaemia via inhibition of the MAPK signalling pathway by binding to EZH2
Q45061101Effect of 1,25(OH)2 Vitamin D3 analogs on differentiation induction and cytokine modulation in blasts from acute myeloid leukemia patients
Q35841859Enhancement by other compounds of the anti-cancer activity of vitamin D(3) and its analogs.
Q91975820LncRNA NR-104098 Inhibits AML Proliferation and Induces Differentiation Through Repressing EZH2 Transcription by Interacting With E2F1
Q22306219Noncalcemic Actions of Vitamin D Receptor Ligands
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Q42427858Vitamin D in combination cancer treatment
Q41514143Vitamin K2 and cotylenin A synergistically induce monocytic differentiation and growth arrest along with the suppression of c-MYC expression and induction of cyclin G2 expression in human leukemia HL-60 cells
Q55090404c-MYC and reactive oxygen species play roles in tetrandrine-induced leukemia differentiation.

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